Peptides for Fat Loss w/ CanLab: Setmelanotide, AOD 9604, FRAG17691, Tesamorelin, CJC 1295 NO Dac

Peptides for Fat Loss w/ CanLab: Setmelanotide, AOD 9604, FRAG17691, Tesamorelin, CJC 1295 NO Dac

In this Interview, Jean-Francois Tremblay, owner of CanLab and I dig in to one of the new darlings of the peptide world - Tesamorelin and a less known but possibly just as effective other option - Setmelanotide - an offshoot of the better known Melantonan 2. We also cover AOD 9604, FRAG 17691 and CJC1295 ...and why you probably want to avoid the version with DAC (drug affinity complex)... We start with a chat about how if you're after lasting results there's really no way to avoid optimizing your diet, moving more, optimizing sleep etc... but these peptides might just help to speed things along and ease some of the bumps along the way.

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Show Notes:

Keto Calorie

Peptides Help with Fat Loss Body Recomposition Growth Hormone unregulated by Fat Loss peptides like FRAG 17691 or AOD9604 (just one amino acid difference) help to mobilize fatty acids in the fat cell – but need to be in calorie/energy deficit for it to stay out

Consistency and sticking to your plan is the ultimate secret sauce…

Why Canlab combines Frag and AOD 9604 More about Frag and AOD….are they the same or different? AOD lacks one tyrosine…means that it lasts longer…whereas Frag uses more up front and gets metabolized faster…..

Tesamorelin…..what it does….

The skinny on Tesamorelin….it's not about Tesa it's about the growth hormone release….

Re Muscle Gains attributed to Peptides….in studies re old people it's about bringing back muscle you once had…. Hormone replacement therapy is at the foundation of reclaiming muscle mass GH good for muscle sustaining (vs growth) and tissue repair (but doesn't hold a candle to BPC and TB4)

Tesamorelin – origins – where it came from originally….very close to CJC 1295 (Mod IGRF 121 is actually CJC 1295 without dac). and other Growth Hormone Secretagogues.

The difference between Tesa and CJC not really all that great….why some people may be promoting Tesa over CJC 1295 the magic is in the dose.

Difference about with Dac and without Dac. With Dac too many peaks of growth hormone (similar to MK 677….increases risk of insulin resistance…..why is the Dac long lasting…binds to albumin in the blood ….which is problematic as there may have been relationship to blood cancer seen in certain studies….so better to use without DAC…just use multiple times a day if necessary

Post workout (3) is a good time…but pre bed(1), pre workout and first thing in the morning (2) are all better

Setmelanotide – another derivative of alpha MSH (Melanotan, melanotan 2, PT141) Basically prioritizes appetite suppression over tanning and sexual enhancement..they all create a tan just to varying degrees…. SM get appetite curbing (some sexual stim)…increases metabolic rate by about 6%, without increasing HR or BP…. On average can expect about 1 lb a week fat loss…. Many reports of people using it with good results – safe track record…..Clinical studies went for 12 months

Do not start at full dose of 1.5mg a day….start at .5 1-2 days then 1.0mg for a couple of days and then increase to full dose to avoid possible /nausea In studies – they changed nothing else….and saw results but it's likely that as people lost weight they may have started to move more etc…

At this point best method for most peptides is SubQ over oral….Intranasal may work but need to use higher dose (aka PT141 1 mg is SubQ and 2mg is IntraNasal)

Tesofensine – not a peptide acts on dopamine and AC receptors in the brain so needs to be used with great caution Please note that this video is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition.

Episoder(384)

#330: Lose the Bloat, Fix Your GUT: Inside the Microbiome Revolution (Skin, Weight & Longevity Secrets) with Dr William Davis

#330: Lose the Bloat, Fix Your GUT: Inside the Microbiome Revolution (Skin, Weight & Longevity Secrets) with Dr William Davis

On this episode of the Longevity Podcast, host Nathalie Niddam is joined by renowned cardiologist and bestselling author Dr. William Davis for a deep dive into the powerful connection between gut health, the microbiome, and vibrant longevity. Dr. Davis—who made waves with his groundbreaking books Wheat Belly and Super Gut—shares his journey from mainstream cardiology to pioneering work on the true drivers behind chronic disease, fat gain, and aging. What we discuss: Meet Dr. William Davis & Wheat Belly origins ... 00:04:00 From cholesterol to calcium scoring ... 00:10:00 Dramatic health wins from removing wheat, grains, sugar ... 00:14:00 Transition to the microbiome & SIBO ... 00:19:00 Modern SIBO causes and prevalence ... 00:24:00 SIBO yogurt strategy and benefits ... 00:31:00 Women's health, pregnancy, and key microbes ... 00:47:00 Actionable gut health tips and food swaps ... 01:03:00 Fermentation: dos and don'ts ... 01:21:00 Where to find Dr. Davis and wrap-up ... 01:23:00 Our Amazing Sponsors: Peptide Pro App: can help manage every part of your peptide protocol. From smart scheduling to real-time dose checklists, note taking, and easy calculations. Listeners receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today. Puori - 21 grams of high-quality whey protein from pasture-raised cows with no hormones, GMOs, or pesticides. Ready to ditch the questionable protein powders? Visit Puori.com/NAT and use my code NAT to get 20% off your first order! Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Head to profound-health.com and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

29 Apr 1h 27min

#329: How C60 Is Changing Aging: Energy, Brain Health, and Recovery Insights With Ian Mitchell

#329: How C60 Is Changing Aging: Energy, Brain Health, and Recovery Insights With Ian Mitchell

In this episode, we're going deep on Carbon 60—also known as C60 or buckyballs. If you've ever wondered how a molecule that started life as an industrial lubricant ended up a star player in the world of anti-aging, you're in for a treat. Ian and I talk about the original studies that blew everyone's minds (including a rat study where the animals lived nearly twice as long as expected!), and we discuss Ian's own hands-on research, from mouse models to dogs, horses, and even human applications. What we discuss: C60 explained: origins, "buckyballs," and research ... 00:08 C60 rat and mouse longevity studies ... 00:09 Lipid binding & targeted delivery ... 00:16 C60: antioxidant, adaptogen, mitochondrial effects ... 00:18 Athlete case study & performance benefits ... 00:25 Applications for fatigue, brain fog, metabolic issues ... 00:32 Autoimmune/inflammatory benefits & mitochondrial origins ... 00:34 Hair, scalp, and ovarian health ... 00:38 Neurodegeneration, glymphatics & brain serums ... 00:45 Optimizing cognition & cycling C60 ... 00:51 Safety notes: who should avoid and why ... 00:53 Product lineup & new developments ... 01:01 What to look for in C60 products ... 01:09 Our Amazing Sponsors: LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT for 20% off your order. Peptide Pro App - When you're working with multiple peptides, timing and precision matter. From smart scheduling to real-time dose checklists, it keeps things organized and on track. Receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today. Wizard Sciences (Neural Rx) - designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

25 Apr 1h 13min

#328: Mastering Facial Rejuvenation: Botox, Fillers, Facelifts & Fundamentals with Dr. Amir Karam

#328: Mastering Facial Rejuvenation: Botox, Fillers, Facelifts & Fundamentals with Dr. Amir Karam

Today, I'm joined by the exceptional Dr. Amir Karam, a genius at the intersection of science and art in facial aesthetics. I've been following Dr. Karam's work for years, and having him on the show feels like a fantastic opportunity to explore why our faces age and what we can truly do to maintain a youthful appearance.   What we discuss: Dr. Amir Karam's Background ... 00:07:35 Facial Rejuvenation Evolution ... 00:08:46 Historical Context of Facelifts ... 00:09:20 Vertical Approach in Rejuvenation ... 00:12:37 Genetics and Aging ... 00:20:39 Importance of Skin Care ... 00:23:00 Fillers' Long-Term Impact ... 00:34:04 Botox Best Practices ... 00:42:19 Skin Care Techniques ... 00:46:31 Light Therapy and Microcurrent ... 00:47:01 Diet and Skin Health ... 01:00:44 Surgical Outcomes and Longevity ... 01:17:29   Our Amazing Sponsors: Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Visit  troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there.   Qualia - NAD+ This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off!   Quantum Upgrade - Imagine plugging yourself into a limitless power source rigorously tested and shown to improve blood flow, reduce stress, and even boost cellular energy by up to 29%. Try it today at quantumupgrade.io/NAT and start running life, instead of life running you. Use my code NAT15 to get a 15-day free trial on the All-in-One Frequency Bundle. Good through June 1st, 2025   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

22 Apr 1h 23min

#327: Testosterone for Women: Enhancing Strength, Libido, and Cognitive Function With Nat Niddam

#327: Testosterone for Women: Enhancing Strength, Libido, and Cognitive Function With Nat Niddam

Hey there, Longevity Podcast listeners! It's just me, Nathalie Niddam, in today's episode, diving into a subject that's often overlooked but super important—testosterone in women. Yes, you heard that right! While most people think of testosterone as a "male" hormone, it plays a crucial role in women's health, especially as we navigate through menopause. What we discuss: Testosterone in Women ... 00:00:37 Muscle Challenges ... 00:02:10 Sexual Function ... 00:04:33 Energy Levels ... 00:05:14 Cognitive Function ... 00:05:56 Mood and Bone Health ... 00:05:56 Muscle and Cardiovascular Health ... 00:07:02 Somatic Symptoms ... 00:09:01 Sleep and Motivation ... 00:10:14 Cautions with Therapy ... 00:11:13 Administration Methods ... 00:14:38 Transdermal vs. Injectable ... 00:16:47 Our Amazing Sponsor: BiOptimizers - MassZymes is the most complete, most potent digestive enzyme with over 102% MORE PROTEASE than the nearest competitor. That's crucial because protein is the most complex macronutrient to break down. Try MassZymes at bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

18 Apr 26min

#326: From Brain Fog to Focus: Techniques and Supplements to Enhance Cognitive Function With Kyal Van Der Leest

#326: From Brain Fog to Focus: Techniques and Supplements to Enhance Cognitive Function With Kyal Van Der Leest

In this episode of the Longevity Podcast, I sit down with my good friend and brilliant supplement formulator, Kyal Van Der Leest, who's known for his innovative work in the peptide space. Together, Kyal and I explore the fascinating world of brain health and uncover powerful strategies to boost cognitive function. What we discuss: Mold toxicity and health effects ... 00:03:49 Kyal's journey and Level Up Health ... 00:04:26 Lifestyle factors in brain health ... 00:19:19 Role of BDNF in neuroplasticity ... 00:24:44 Overview of neurotransmitters ... 00:30:12 Tessa Fensin and market withdrawal ... 00:39:01 Peptides for brain health ... 00:46:18 Blood flow and botanicals ... 00:53:06 Liposomal delivery benefits ... 01:06:22 Creatine for brain health ... 01:13:02 Kyal's supplement quality commitment ... 01:19:04 Conclusion and product info ... 01:26:00 Our Amazing Sponsors: Timeline: Mitopure is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10. Wizard Sciences (Neural Rx) - isn't just about a quick boost. It's designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. It supports mitochondrial efficiency, for more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com. Young Goose L.A.D.R. Serum - Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Future-proof your face. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

15 Apr 1h 27min

#325: No More 3PM Burnout: How to Have A Successful Workday AND Energy Left for What Matters Most At The End Of The Day with Greg Kelly

#325: No More 3PM Burnout: How to Have A Successful Workday AND Energy Left for What Matters Most At The End Of The Day with Greg Kelly

Today's guest, Dr. Gregory Kelly, creator of Qualia Mind, has spent years studying how to help people think faster, age better, and avoid that 3 p.m. crash that turns you into a zombie. If you've ever wished for an extra gear in your mental engine, this is the episode for you! And if you are interested in giving it a try, visit qualialife.com/nathalie and use promo code NATHALIE to save 15% on your order. What we discuss: Difference Between Brain and Mind ... 00:07:03 Mental Energy and Brain Function ... 00:09:49 Glucose and Ketones as Brain Fuel ... 00:17:45 Nootropic Supplements and Their Impact ... 00:24:53 Stacking Compounds for Cognitive Performance ... 00:34:07 Short-term and Long-term Benefits of Ingredients ... 00:43:18 Using Nootropics Like Qualia Mind for Performance ... 00:52:28 Safety and Effectiveness of Ingredient Stacking ... 01:16:40 Five Tips for Maintaining Cognitive Energy ... 01:19:15 Conclusion and Final Thoughts ... 01:26:28 Our Amazing Sponsors: STEMREGEN - Triggers the release of 10 million of your own stem cells, supporting tissue repair, recovery, and overall longevity. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order. BEAM - These minerals come from humate, a natural substance formed over millions of years as freshwater plants broke down and deposited their nutrients into the soil. Over time, those minerals concentrated into this black, crystalline material that's now one of the most mineral-dense substances on earth. Visit https://www.beamminerals.com/NAT20 and use code NAT20 for 20% off. Profound Health - Nature's Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They're manufactured in the UK. They're GMP and HACCP certified and FDA-compliant. Head to profound-health.com and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

11 Apr 1h 28min

#324: Master Your Nervous System: Overcoming Toxic Loads & Trauma for Better Health with Dr Jess Peatross

#324: Master Your Nervous System: Overcoming Toxic Loads & Trauma for Better Health with Dr Jess Peatross

In this episode of the Longevity Podcast, host Nathalie Niddam welcomes Dr. Jess Peatross, a former hospitalist turned functional medicine expert, to delve into the intricacies of nervous system regulation and terrain theory. What we discuss: Themes of Terrain Theory and Germ Theory ... 00:07 Impact of Trauma on Health ... 00:10 Dr. Jess's Personal Health Journey ... 00:14 Meditation and Mindset Practices ... 00:22 Explanation of MCV and Its Importance ... 00:26 The Role of the Heart Center ... 00:31 Nervous System Regulation Tools ... 00:50 Mind and Body Coherence ... 00:54 Conclusion and Positive Message ... 01:00 Where to Find Dr. Jessica Petros ... 01:01 Our Amazing Sponsors: Young Goose L.A.D.R. Serum - Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage while you go about your life. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Qualia - NAD+ This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off! Quantum Upgrade Imagine plugging yourself into a limitless power source. It's been rigorously tested and shown to improve blood flow, reduce stress, and even boost cellular energy by up to 29%. Go to quantumupgrade.io/NAT and start running life, instead of life running you. Use code NAT10 to get a 15-day free trial on the All-in-One Frequency Bundle. Good through June 1st, 2025. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

8 Apr 1h 2min

#323: Understanding Sugar Alternatives | Which Ones Are Better For You with Nathalie Niddam

#323: Understanding Sugar Alternatives | Which Ones Are Better For You with Nathalie Niddam

In this episode, Nathalie explores the captivating world of sweeteners, from the natural delights of honey and maple syrup to modern alternatives like stevia, monk fruit, and artificial sweeteners.    Resources from the episode: What Are the Dangers of Erythritol? Aspartame Side Effects: Recent Research Confirms Reasons for Concern Trehalose: Benefits, Uses, Food Sources & Dangers Is Allulose a Healthy Sweetener?   What I discuss: Anthropological Perspective on Sweetness ... 00:01:37 Brains Glucose Utilization and Sugar Relationship ... 00:02:03 Sugar Addiction and Sweet Cravings ... 00:03:00 Exploration of Food-Based Sweeteners ... 00:04:17 Detailed View on Honey ... 00:05:27 Maple Syrup Overview ... 00:07:14 Stevia - Pros and Cons ... 00:08:02 Monk Fruits Benefits ... 00:10:59 Coconut Sugar Insights ... 00:12:04 Artificial Sweeteners Discussion ... 00:13:06 Sucralose Controversy ... 00:13:37 Saccharin and Historical Concerns ... 00:14:08 Aspartame Risks ... 00:15:13 Sugar Alcohols - Xylitol ... 00:16:50 Erythritol Concerns ... 00:19:56 Potential of Allulose ... 00:21:14 Trehalose Properties ... 00:23:24 Final Thoughts on Sweeteners and Detox ... 00:25:57   Our Amazing Sponsor: LVLUP - Neuro Re-Generate: the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT for 20% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

4 Apr 34min

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