Spermidine – The Powerful AntiAging compound you've never heard of but is about to take the world by storm

Spermidine – The Powerful AntiAging compound you've never heard of but is about to take the world by storm

Primeadine
Spermidine – The Powerful AntiAging compound you've never heard of but that is about to take
the world by storm. In this episode I sit down with Leslie Kenny the CEO and Founder of
OxFord Healthspan – a company founded for the purpose of bringing powerful healthy/anti
aging compounds to market. Today we deep dive into their first entry which is rooted in
ancient knowledge and yet relatively new to the modern world. Consider that this compound
hits at least 5 of the 9 hallmarks of aging….even better, new research seems to point to its
ability to improve immune response in elderly adults by helping certain areas of the immune
system to reboot and rejuvenate!! Oxford Span is committed to making this
supplement available to as many people as possible – for the month of December you can
benefit from introductory pricing PLUS an additional 15% discount (BIONAT15 promo code). If
you are this after December 2020 the discount code will still work!!
Note that this supplement will produce most noticeable results in the 50+ crowd who are
already seeing a decline in endogenous spermidine production and is not appropriate for
people with celiac disease or severe wheat allergies – we talk about all this and more in the
episode….enjoy!!
6:08
Leslie's story – from autoimmune disease & infertility to how she first came across spermidine
7:22
The link between ancient Japanese scrolls on longevity and sexual intimacy and spermidine
11:05
Compounds that target the 9 hallmarks of aging and the 5 specifically targeted by Spermidine
13:30
Dietary sources and the reason why supplement companies are having to extract spermidine
from wheat instead of Natto
15:30
Natto – possibly the best and most economical source of spermidine
17:33
Who should NOT use the current Spermidine supplements (including Primeadine) and why
18:02
Amount of gluten per serving vs a slice of
19:54
Why the 50+ crowd is likely to experience the best visible results from Primeadine
20:55

Endogenous and exogenous sources of spermidine
22:57
The physical signs that your spermidine production is declining
28:20
Short, medium and long term benefits
36:05
Maximum dose as determined by regulatory bodies
38:49
Getting back to the ancient Daoist Scrolls – the aging male's advantage over women

45:29
Best time of day to take Primeadine
50:27
DO NOT mix with hot foods or beverages
52:25
Introductory pricing in place until December 31, 2020
15% discount code in place for December and the new year: BIONAT15
Website:
Primeadine.com or OxfordHealthSpan.com

Just a few of the growing list of studies assessing Spermidine's possible benefits for human
and longevity
Studies/References
Effect on Hormones, Fertility in men and women
The regulatory effect of biogenic polyamines spermine and spermidine in men and women. Open
Journal of Endocrine and Metabolic Diseases, 9(03), 35
Spermidine Intake and Longevity in humans
Higher spermidine intake is linked to lower mortality: a prospective population-based study. The
American journal of clinical nutrition, 108(2), 371-380
The autophagy enhancer spermidine reverses arterial aging in aged mice. Mechanisms of ageing
and development, 134(7-8), 314-320.

Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary
foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-
1584
Ramot, Y., Tiede, S., Bíró, T., Bakar, M. H. A., Sugawara, K., Philpott, M. P., ... & Paus, R. (2011).
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell
functions. PLoS One, 6(7), e22564
Rinaldi, F., Marzani, B., Pinto, D., & Ramot, Y. (2017). A spermidine-based nutritional supplement
prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-
blind study. Dermatology Practical & Conceptual, 7(4), 17.
Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020).
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
NeuroImage, 221, 117132
Dietary polyamine intake and colorectal cancer risk in postmenopausal women. The American
journal of clinical nutrition, 102(2), 411-419

And finally an article on new findings of the effects of Spermidine on immune function is elderly
humans:
https://www.longevity.technology/autophagy-in-t-cells-maintained-by-
spermidine/?utm_source=ZohoCampaigns

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Episoder(384)

#354: The DARK Side of Bodybuilding: Eating Disorders, Cellular Health & Peptide Power—How Dylan Gemelli Rebuilt Everything

#354: The DARK Side of Bodybuilding: Eating Disorders, Cellular Health & Peptide Power—How Dylan Gemelli Rebuilt Everything

In this episode of the Longevity Podcast, I sit down with Dylan Gemelli—a name many of you may know from the bodybuilding world and the pioneering days of biohacking. Our conversation takes a very personal turn, as Dylan bravely opens up about his early struggles with body image, bulimia, and body dysmorphia, and how these challenges set the stage for his journey into fitness, nutrition, and ultimately, cellular and mitochondrial optimization. Free "Top 5 Peptides" Download from Nat: https://natniddam.com/Top5 What we discuss: Trigger warning: Eating disorders ... 00:03:52 Early body image struggles ... 00:08:11 Eating disorders and sports ... 00:11:11 Addiction and life rebuild ... 00:16:40 Steroids, SARMs, and peptides ... 00:18:08 Public criticism and dysmorphia ... 00:19:04 Biohacking and diet overhaul ... 00:20:42 Heart risk and labs ... 00:27:23 Individualized diet lessons ... 00:39:44 Evolving coaching philosophy ... 00:41:50 Urolithin A & methylene blue ... 00:46:28 Podcast vision and legacy ... 00:52:32 Our Amazing Sponsors: Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off. StemRegen - A plant-based supplement protocol designed to enhance stem cell function, support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order. Mimio - A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you're eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

22 Jul 1h 10min

#353: Melatonin 101: Antioxidants, Gut Health, Sleep, Skin Protection, and Cancer Research with Nat Niddam

#353: Melatonin 101: Antioxidants, Gut Health, Sleep, Skin Protection, and Cancer Research with Nat Niddam

Today, I'm flying solo for a deep—well, more like a just-scratching-the-surface—dive into one of the body's most fascinating hormones: melatonin. After getting so many of your questions about how melatonin really works, whether it's just about sleep, and how it might support healthy aging, I decided to tackle all those hot topics head-on in this episode. Download my FREE guide to my top 5 peptides for longevity: https://www.natniddam.com/top5 Melatonin Product mentioned: https://symphonynaturalhealth.com/?_ef_transaction_id=&oid=2&affid=161 and the code is NAT What we discuss: Why melatonin is complex; plans for future episodes ... 00:00:42 Melatonin as darkness hormone; comparison with vitamin D ... 00:01:51 Top science-backed facts about melatonin ... 00:03:25 Light exposure's impact and blue light mitigation tips ... 00:05:09 Bioidentical melatonin in plants and animals; supplement notes ... 00:06:41 Production in pineal gland and gut; unique roles ... 00:07:24 Melatonin decline with age and rationale for supplementation ... 00:09:02 Calcified pineal gland and bioregulator benefits ... 00:10:03 Melatonin's antioxidant, skin, mitochondrial, and anti-cancer effects ... 00:10:37 High-dose melatonin in research and cancer ... 00:12:21 Melatonin from food—phytomelatonin vs. synthetic ... 00:18:37 Supplements: dependency, dosing, and genetic factors ... 00:21:57 Practical tips for dosing and timing ... 00:23:22 Potential drug interactions and safety ... 00:27:38 Wide-ranging health impacts and future research ... 00:28:26 Product recommendations and tracking results ... 00:29:55 Our Amazing Sponsor: OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

18 Jul 32min

#352: Biohacker's DREAM: How Plant Exosomes Deliver Cellular Power Like Never Before | Nathalie Niddam x Dr. Jeffrey Gross

#352: Biohacker's DREAM: How Plant Exosomes Deliver Cellular Power Like Never Before | Nathalie Niddam x Dr. Jeffrey Gross

Today, I'm welcoming back Dr. Jeffrey Gross, a true pioneer in the regenerative longevity space. You might remember our earlier episode where we explored the transformative science of human exosomes—but today, we're going even further, straight into the fascinating world of plant exosomes. Visit https://recellnutra.com/?ref=NAT and use code NAT for 10% off What we discuss: Plant exosomes intro ... 00:04:23 Gut health/minerals ... 00:05:18 Why plant exosomes ... 00:08:09 Exosomes vs. liposomes ... 00:09:35 Bioavailability ... 00:12:12 Phytonutrients ... 00:17:26 Resveratrol ... 00:18:17 Quercetin ... 00:20:30 Glutathione ... 00:22:01 Antioxidant enzymes ... 00:24:02 Fruit yield per cap ... 00:25:32 Melatonin ... 00:26:55 Oral bioavailability ... 00:29:29 Research summary ... 00:30:10 Sirtuin 1/ROS ... 00:31:29 Prepping for joint regen ... 00:42:05 Cartilage success ... 00:44:00 European edge ... 00:47:48 B vitamins ... 00:48:25 Microbiome ... 00:51:50 Fisetin/dosing ... 00:53:22 Our Amazing Sponsors: Mimio - A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you're eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order. BEAM Minerals - are one of the most overlooked contributors to a healthy gut. They help feed and support your microbiome. Research shows that good gut bacteria rely on essential minerals like calcium, magnesium, zinc, iron, and phosphorus to thrive.. Head over to www.beamminerals.com and use code NAT20 for 20% off your first order and give your gut the simple support it deserves! Bio-Shield by Young Goose - It's a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

15 Jul 1h 1min

#351: How to Rewire Your Gut (and Mind) For Health: Coffee, Microbiome DIVERSITY, and The Power of Belief | Dr. Vincent Pedre

#351: How to Rewire Your Gut (and Mind) For Health: Coffee, Microbiome DIVERSITY, and The Power of Belief | Dr. Vincent Pedre

Today, I'm joined by the brilliant Dr. Vincent Pedre, one of the most sought-after experts in functional medicine and an incredible advocate for what he calls "gut-centric medicine." Together, we explore how your emotions and beliefs directly impact your gut, why there is no one-size-fits-all approach to gut healing, and the practical steps you can take to support your body's natural balance. What we discuss: Dr. Pedre's personal and medical background ... 00:06:05 Mind-body connection and overcoming fear through meditation ... 00:09:16 Impact of antibiotics and gut health journey ... 00:18:06 Energy healing, boundaries, and the empath-practitioner challenge ... 00:21:05 Gut-brain connection and integrating mindset in healing ... 00:24:45 Mindset, mantras, and patient transformation ... 00:30:04 Personalizing gut protocols and addressing resistance ... 00:39:03 Tools: intuitive eating, true cravings vs. microbiome-driven urges ... 00:47:45 No one-size-fits-all: diversity and personalized gut diets ... 00:54:08 How the Gut Smart Protocol tailors recommendations ... 00:58:54 Probiotics, spore-based options, and gut support basics ... 01:02:48 Coffee as a gut health microhabit (toxins, plastics, quality) ... 01:06:33 Happy Gut Coffee: rationale, tips, and final takeaways ... 01:09:11 Our Amazing Sponsors: StemRegen - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order. Mitolux NEW Second Generation - This second-generation red and near-infrared light therapy panel hits all the marks. Two new wavelengths—810nm and 940nm—target brain performance, deep muscle recovery, and circulation. I use GAMA mode for focus, and Fireplace 2 to wind down. Get a Mitolux BTS2 Sunlamp for 10% off at https://mitolux.com/NAT10, NAT10 will be automatically applied at checkout. MitoBlue - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng. Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

11 Jul 1h 14min

#350: Nature's Longevity CODE Revealed: Exosomes, Plasma HACKS & the Real Science of Aging | With Dr. Ian White

#350: Nature's Longevity CODE Revealed: Exosomes, Plasma HACKS & the Real Science of Aging | With Dr. Ian White

In this episode, I sit down with Dr. Ian White—one of the most exciting researchers in regenerative medicine today. If you're even a little bit curious about how to hack aging or have heard the buzz about things like plasma exchanges, exosomes, or why on earth lobsters never seem to grow old, you're in for a treat. What we discuss: Expanding autologous hematopoietic stem cells and FDA challenges ... 00:08:28 Heterochronic parabiosis, plasma exchange, and aging signals ... 00:17:35 Nature's clues: Lobsters, jellyfish, and biological age reset ... 00:24:02 Entropy, epigenetics, and limiting factors in aging ... 00:27:56 Vision: Youthful healthspan, not just longer lifespan ... 00:32:43 Amniotic fluid as a source of rejuvenation ... 00:36:01 Therapeutic results: burns, ulcers, and immune modulation ... 01:03:18 Exosomes vs. stem cells: Definitions and market problems ... 01:02:31 How exosomes function and the importance of source ... 00:51:23 Ensuring safe and effective regenerative therapies ... 01:00:10 Guidance for patients interested in exosome therapy ... 01:09:42 Dr. White's research legacy and goals ... 01:14:04 Our Amazing Sponsors: Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there. NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Berberine Breakthrough - Take 15 min. before a meal and your body will push carbs and glucose into your muscles to be used as fuel instead of turning them into fat. Enjoy more stable energy without the post-meal crash. Visit bioptimizers.com/bionat and enter the code BIONAT to get 10% off your order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

8 Jul 1h 19min

#349: Jaw-Dropping Moments From The Last 6 Months: The Conversations Still Stuck in My Head With Nat Niddam (Solo)

#349: Jaw-Dropping Moments From The Last 6 Months: The Conversations Still Stuck in My Head With Nat Niddam (Solo)

Today, I've got something special for you: a solo episode where I look back at the past six months and handpick the five episodes and ideas that truly changed the game for me—and, based on your feedback, for many of you too.   Episodes from this podcast: #300: Breast Cancer Overdiagnosis, Mammogram Myths, The REAL Risks For Women And Bold NEW Alternatives With Dr. Jenn Simmons #302: If You Have Creeky or Painful Joints and BIG Dreams of Staying Active, These Nonsurgical Solutions Are The NEW Way Forward - With Dr. Jeff Gross #309: Cordycepin and Methylene Blue: Two Game-Changers For Better Energy, Focus, Sleep, and So Much More With Dr. Scott Sherr #312: Age-Defying Bone Health: Preventing Osteoporosis with Science-Backed Interventions and Reversal Techniques You Can Try TODAY With Doug Lucas #318: Lies He Taught In Medical School: The METABOLIC Secret To Reversing Chronic Disease with Dr. Robert Lufkin   What I discuss: Exosomes for regeneration: cartilage, bone, and joint repair ... 00:02:19 Exosomes vs. PRP and stem cells—key differences ... 00:05:20 Managing inflammation before regenerative treatments ... 00:06:09 Exosomes in neurology & anti-aging ... 00:07:01 Regulation, safety, and advances in exosome therapy ... 00:08:33 Mammogram controversy: risks, overdiagnosis, and dense breasts ... 00:10:00 Alternatives: QT scan benefits and radiation-free screening ... 00:15:21 Optimizing mitochondrial health—importance & methylene blue ... 00:18:28 Widespread mitochondrial dysfunction & modern disruptors ... 00:21:03 How methylene blue supports energy & cautions ... 00:23:17 Bone health: density vs. quality, collagen, and vibration plates ... 00:31:17 Mechanical input & gaps in traditional osteoporosis care ... 00:34:22 Lifestyle reversal of chronic disease ... 00:37:15 Medical system limitations & patient health agency ... 00:39:25 Fasting and metabolic health—power & nuance ... 00:48:06   Our Amazing Sponsors: Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

4 Jul 52min

#348 The Overlooked Power of Your Lymphatic System in Longevity and Recovery (Fascia Release and Deep Healing EXPLAINED) with Dr. Stephanie Canestraro

#348 The Overlooked Power of Your Lymphatic System in Longevity and Recovery (Fascia Release and Deep Healing EXPLAINED) with Dr. Stephanie Canestraro

I'm your host, Nathalie Niddam, and today I'm thrilled to bring you a truly fascinating conversation with Dr. Stephanie Canestraro—a chiropractor, functional medicine practitioner, and someone with an incredible personal story about overcoming chronic illness. Dr. Canestraro works with elite athletes, including NHL players, but her expertise comes from her own journey through mysterious health challenges that eventually led her to discover the vital role of the lymphatic system. What we discuss: Dr. Canestraro's personal health journey and lymphatic issues ... 00:07:58 Explanation of the lymphatic system ... 00:10:33 Superficial vs. deep lymphatics and fascia's role ... 00:15:20 Personal stories of lymphatic stagnation and deep lymph solutions ... 00:17:03 Why movement isn't always enough for lymph flow ... 00:2447 Modern challenges: EMFs, toxins, fascia, and liver ... 00:25:00 Lymph, anxiety, and the vagus nerve ... 00:35:40 Tools and approaches for lymph support ... 00:39:22 Body-wide impact of fascia ... 00:43:47 Frequency medicine and resilience strategies ... 00:51:16 Our Amazing Sponsors: Bio-Shield by Young Goose - It's a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there. OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

1 Jul 1h 3min

#347: Left vs Right Brain: The NEW Science Behind ADHD, OCD & Childhood Development With Dr. Robert Melillo

#347: Left vs Right Brain: The NEW Science Behind ADHD, OCD & Childhood Development With Dr. Robert Melillo

In this episode, I'm thrilled to sit down with Dr. Robert Melillo, a clinical neuroscientist with nearly 40 years of experience decoding the mysteries of the brain and how our modern lifestyle—and especially technology—are changing it. If you've ever worried about what all that screen time means for your kids' developing brains (or your own), this conversation is going to give you a whole new perspective. What we discuss: Left/right brain imbalance and modern tech's impact ... 00:12:31 Gut health, peptides, and foundational health tips ... 00:05:37 Dr. Melillo's journey, research, and clinical experience ... 00:08:04 Technology's rapid evolution vs. brain adaptation ... 00:12:31 Making brain health more accessible ... 00:15:39 Biohacking brain interventions: risks and basics ... 00:17:34 ADHD, OCD, and the connectivity problem ... 00:20:14 How brain imbalances manifest and can be changed ... 00:23:45 Root causes: movement, milestones, and environment ... 00:39:09 Functional treatment: targeted, practical steps ... 00:47:25 Technology, lifestyle, and the left-brain epidemic ... 00:55:50 Correcting imbalances at any age ... 01:06:02 Dr. Melillo's resources and how to learn more ... 01:14:38 Our Amazing Sponsors: CAROL Bike: With its cutting-edge, science-backed method, CAROL Bike can boost your VO2max by 12% in just 8 weeks—essentially rewinding your fitness clock by a decade. The folks at CAROL Bike are offering a 100-day FREE trial! Visit http://carolbike.pxf.io/Nat or use code NAT100 for a free 100-day trial. Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off. Berkeley Life: Nitric oxide is key for blood flow, energy, brain clarity, and even healthy blood pressure. When you subscribe at BerkeleyLife.com/NAT, you'll get a free tube of 50 nitric oxide test strips with your first delivery, so you can track how your body responds. Visit BerkeleyLife.com/NAT and click "Subscribe" to get started. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

27 Jun 1h 16min

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