Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

  • Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
  • The mitochondria in your cells make energy (ATP)
  • There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
  • Cancer cells ferment - therefore they don't use oxygen
  • Not all cancer cells have genetic mutations, but all cancer cells ferment
  • The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
  • This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
  • The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
  • On the other hand, normal cells use oxygen and very little amounts of glucose
  • This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
  • Have to re-emphasize the fact that the DNA damage comes as a downstream effect
  • Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
  • The oxidative stress also causes damage to the nucleus and the genome
  • The field of cancer research studies effects instead of causes
  • We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
  • This is supported by thousands of experiments and studies
  • Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
  • We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
  • Cancer cells can't use ketones
  • There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
  • Basically nobody he's heard of is treating it this way
  • If it's so clear this is how cancer works, why has this not reached the mainstream?
  • The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
  • Entrenched beliefs continue this. Also funding money is all based around the genetic theory
  • If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
  • Cancer is a result of the industrialization as a society
  • Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
  • Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
  • These are all secondary - the root cause is damage to the respiration
  • Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
  • To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
  • Metabolic therapies need to at least be options for people
  • Problem is doctors aren't aware of them or aren't trained on them
  • Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
  • There's therapeutic weight loss and toxic weight loss
  • Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
  • Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
  • Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
  • ROS damages tissues and is why you age
  • He published the glucose-ketone index calculator
  • People need to realize sweets are a treat once in awhile - not an everyday thing
  • The food industry has played into our ancient desires for sweet
  • Otto Warburg studied cancer in the early 1900s
  • He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
  • Because their mitochondria are defective they can't switch back to oxidative phosphorylation
  • He recently published a paper filling in the gaps from Otto Warburg's work
  • Missing link was the glutamine that cancer cells can also use
  • Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
  • He's developed the press-pulse system in his lab to attack tumors strategically
  • Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
  • He's having trouble getting funding for this for some reason
  • One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
  • People are going to have to participate in the management of their disease and the culture of the diseases has to change
  • Another problem is the high cost of these standard therapies - people have to pay $400k
  • His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
  • If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
  • The wheelchair doesn't cause your legs to not work
  • Needle biopsies are putting people at risk and are pointless
  • He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
  • What do critics of his views say? They try to create doubt
  • They rely on private funding and some great organizations supporting this research
  • Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
  • His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
  • Dr. George Yu's foundation https://yufoundation.org
  • Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
  • Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Episoder(235)

Part 155 - Dr. Malcolm Kendrick on The True Cause of Heart Disease? The Unifying Theory

Part 155 - Dr. Malcolm Kendrick on The True Cause of Heart Disease? The Unifying Theory

Dr. Malcolm Kendrick is a General Practitioner in Medicine from Scotland, and focuses the bulk of his research and writing on cholesterol, atherosclerosis, stress, and the myths around them. He is an outspoken critic of the cholesterol focus of heart disease, overprescription of medications, and the dirty plays of statistics that some doctors use to increase their gains at the expense of their patients and general population. He is the author of three books, The Clot Thickens, Doctoring Data, and The Cholesterol Con, and runs the website drmalcolmkendrick.org GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: [0:50] - Brian and Malcolm chat about Malcolm recent book, The Clot Thickens, and a brief overview of heart disease, its history and Malcolm's thoughts on it [10:01] - Malcolm details the nuance of atherosclerosis, endothelial cells, and damage to blood vessels [19:40] - Malcolm's thoughts on using LDL as a risk factor for cardiovascular events [31:20] - Myths and facts around cholesterol and its role in physiology [36:00] - Diving deep into Malcolm's thrombogenic hypothesis of heart disease, blood clots and endothelial pathology, Sickle Cell disease and Diabetes [59:21] - Nitric oxide, how it's benefits were found and how to increase it [1:04:21] - How stress correlates to increased risk of cardiovascular disease [1:08:45] - Malcolm's thoughts on lifestyle, diet, and relationships that help or hurt your chances of adverse cardiovascular events [1:14:30] - How Malcolm's thoughts on these topics have changed or cumulated over the years GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

13 Apr 20221h 23min

Part 154 - Zoe Harcombe PhD on the Upside Down World of Health Policy

Part 154 - Zoe Harcombe PhD on the Upside Down World of Health Policy

Zoe Harcombe, PhD is a researcher, author, blogger and public speaker in the field of diet and health. Her areas of interest/expertise are public health dietary guidelines (especially dietary fat), nutrition and obesity. She regularly is interviewed on TV, radio, newspapers and magazines.   She has a BA and MA from Cambridge University (economics/maths) as well as a Ph.D. in public health nutrition. Her thesis title was "An examination of the randomised controlled trial and epidemiological evidence for the introduction of dietary fat recommendations in 1977 and 1983: A systematic review and meta-analysis." The full document is available to site members here.   Zoe has also offered 50% a year membership to her amazing website where you get all of her articles. My listeners can use this code PH2204 https://www.zoeharcombe.com/register/membership-annual   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES [1:30] - Zoe's background and why she wrote her thesis on the lack of evidence for the introduction of food guidelines [4:30] - Cutting calories and why it doesn't work to focus on it  [10:40] - Brian asks Zoe how to properly lose fat [16:30] - Zoe's take on low carb and what she thinks we should be eating  [27:40] - Zoe's take on animal vs plant foods in relation to nutrition and protein content [39:30] - Zoe's take on the Food Pyramid and how we got into this awful situation  [50:05] - Power dynamics in society and how it relates to our approach towards kids' health in western societies [1:07:40] - Zoe's thoughts on the World Health Organization and The Great Reset [1:20:50] - How this conversation ties into the ostracisation on red meat and the organizations behind it   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

7 Apr 20221h 30min

Part 153 - Dr. Michael Ruscio on All Things Gut Health

Part 153 - Dr. Michael Ruscio on All Things Gut Health

I had a great talk with Dr. Michael Ruscio today on all things gut health! Dr. Ruscio is Doctor of Natural Medicine, Doctor of Chiropractic, clinical researcher and author [1, 2]. His work has been published in peer-reviewed medical journals and he is a committee member of the Naturopathic Board of Gastroenterology research division. His high quality probiotics: https://store.drruscio.com/?rfsn=6444749.3a233de

30 Mar 20221h 10min

Part 152 - Josh Trent on the 5th Pillar of Health

Part 152 - Josh Trent on the 5th Pillar of Health

I usually talk about the 4 pillars of health which I focus on most - diet, sleep, a form of exercise, and sun/outdoors. Josh has been studying what I'm calling the 5th pillar which is the mind/body/spirit stuff that includes stress, breathing, emotional intelligence, etc. I had a great time recording this with him at his home in Austin. We did an hour in the sauna and a cold plunge afterwards!   Josh Trent is the Founder of Wellness Force Media, host of the Wellness + Wisdom Podcast and the creator of the BREATHE a Breath & Wellness Program.   Josh has spent the past 19+ years as a trainer, researcher, and facilitator discovering the physical and emotional intelligence for humans to thrive in our modern world.   Josh and Wellness Force Media Mission is to help humans heal mental, emotional and physical health through podcasts, programs, and a global community that believes in optimizing our potential to live life well.   Josh has dedicated his life to supporting humanity coming together as one.   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org     SHOW NOTES [1:28] - Josh's Background and journey to Wellness Force  [8:15] - Brian's asks Josh to help us understand the spiritual, mental and emotional side of well-being  [22:00] - The Art, Science and Technique  of Breathwork [35:16] - How Past Trauma and Breathwork are related [44:45] - Tips for better breathing posture  [50:30] - The Beginning, Middle and End of Breathwork [57:00] - Looking at Breathwork through an Ancestral Lense [1:01:10] - Josh and Brian's thought son Psychedelics [1:10:00] - The trap of being uncomfortable in our modern life [1:15:45] - What the BREATHE: Breathe and Wellness program and Why Breathwork is so powerful to Josh   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Mar 20221h 29min

Part 151 - Dr. Nick Nwabuaze (The Fittest Doc) Practical Strategies to Improve your Health & Body

Part 151 - Dr. Nick Nwabuaze (The Fittest Doc) Practical Strategies to Improve your Health & Body

Dr. Nwabueze is a board-certified Family Medicine physician who focuses on helping his patients fix the root cause of their stress and poor health. He completed medical school at the Ohio State University College of Medicine and finished his internship and residency at Adventist Hinsdale Hospital in Illinois. He currently uses a mix of resistance training, nutrition coaching, and lifestyle management to form long term relationships with his clients, improving their overall health and happiness through Steady MD, using the Direct Primary Care modality. Find him on Instagram and other social media platforms @thefittestdoc GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDEhttp://sapien.org SHOW NOTES [1:45] - Dr. Nick's Background and Beginning [5:52] - Brian and Nick's thoughts on "Movement is Medicine" [10:50] - How Movement plays into Fat Loss [19:45] - How everything that we put our body through (food, exercise, work) is all stress and how we hormetically get stronger and fitter long-term [23:30] - How and why you should measure Body Composition [32:30] - Brian and Nick's Workout Routines [43:25] - Nick's Mindset on Diet and Nutrition [51:25] - How Dr. Nick works though obesity, obese clients, and mainstream views around obesity [1:21:00] - How Dr. Nick practices medicine with SteadyMD and why he loves it Reach Nick here on SteadyMD GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDEhttp://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg http://youtube.com/c/foodlies

4 Mar 20221h 30min

Part 150 - Richard Perkins on the True Diet of Our Ancestors and Replicating this in Sweden

Part 150 - Richard Perkins on the True Diet of Our Ancestors and Replicating this in Sweden

Richard Perkins is a worldwide leader in the regenerative agriculture space, an author, educator, and farmer. He lives in Sweden with his family on a holistically managed and integrated farm producing a variety of animal and plant foods for his family and community. His practices have taught him how humans must have provided food for themselves for the lion's share of history. From his decades of experience combined with the scientific literature and other accounts around the world, it's apparent they were eating locally & seasonally and relying on nose to tail animal nutrition for the majority of their calories. Please enjoy this episode! GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Mar 20221h 33min

Part 149 - Chris Masterjohn, PhD on Analyzing the Hidden Data You're Not Hearing About

Part 149 - Chris Masterjohn, PhD on Analyzing the Hidden Data You're Not Hearing About

23 Feb 20221h 25min

Part 148 - Dr. Chris Palmer on Incredible Cases of Diet & Lifestyle Reversing Depression, Bipolar, and Schizophrenia

Part 148 - Dr. Chris Palmer on Incredible Cases of Diet & Lifestyle Reversing Depression, Bipolar, and Schizophrenia

In this episode, I had a wonderful conversation with Dr. Chris Palmer who uses diet and lifestyle changes to improve the lives of people suffering from mental and metabolic illness. As you'll learn in the show, there is a metabolic component of many mental health conditions.   Dr. Palmer has been exploring dietary changes, like the ketogenic diet, as treatment for conditions such as schizophrenia, bipolar disorder, and depression. He shares some amazing and inspiring stories that need to be shared with the world if we want to see meaningful changes to our medical system!   Dr. Palmer has been involved in psychiatric research for over 23 years. He received his medical degree from Washington University School of Medicine. He did his internship and psychiatry residency at McLean Hospital, Massachusetts General Hospital, and Harvard Medical School. He is currently the Director of the Department of Postgraduate and Continuing Education at McLean Hospital and an Assistant Professor of Psychiatry at Harvard Medical School.   He has been pioneering the use of the ketogenic diet as a treatment for psychiatric disorders. This is an evidence-based treatment for epilepsy, and epilepsy treatments are commonly used in psychiatry. Additionally, the ketogenic diet has profound effects on brain metabolism that may correct some of the metabolic abnormalities often found in people with mental disorders. He is working with researchers from around the world to assess the effectiveness of this treatment in real people and better understand its mechanisms of action.   Check out his website! - https://www.chrispalmermd.com   DISCLAIMER: The opinions and information provided here by Dr. Chris Palmer and Brian Sanders are not to be taken as medical advice.     SHOW NOTES [3:30] The ketogenic diet and alcoholism [10:30] The ketogenic diet is an evidence-based treatment for epilepsy [13:40] Dr. Chris Palmer's background and personal story [21:40] Why diet works when other treatments fail [26:40] Long-standing psychiatric symptoms resolving with Keto [33:10] Metabolic flexibility and mental health [37:00] Why there's no one-size-fits-all diet [40:40] What happens when patients return to their old habits? [46:00] Treating epilepsy and bipolar disorder with keto [53:40] Mental disorders are metabolic disorders of the brain [57:40] Regular exercise is important, but not enough [1:01:40] Why isn't exercise enough for some people? [1:07:40] Depression is skyrocketing – can diet sometimes help? [1:13:00] Depression and comfort foods [1:15:40] Dr. Chris Palmer is working on a book!   GET THE MEAT! http://NosetoTail.org  GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org  Follow along: http://twitter.com/FoodLiesOrg  http://instagram.com/food.lies  http://facebook.com/FoodLiesOrg

22 Des 20211h 20min

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