#388: Nat's Ultimate Gift Guide for Longevity Fans: Biohacks, Wellness Gadgets, and Black Friday Deals

In this episode Nathalie talks to Dr Mindy Pelz about her new book - The Menopause Reset - virtually a "user's manual" on how women can reclaim power over their health by understanding and supporting their hormones. The book is fantastic - it is short and to the point and explains in detail how each woman can make simple yet powerful changes to their diet and lifestyle that will support their cycles while helping them to look, feel and perform their best. Meet this week's guest: Dr. Mindy Pelz, D.C is a best selling author, keynote speaker, nutrition and functional medicine expert who has spent over two decades helping thousands of people successfully reclaim their health. She is a recognized leader in the alternative health field and a pioneer in the fasting movement, teaching the principles of a fasting lifestyle, diet variation, detox, hormones, and more. Her popular YouTube channel combines the latest science with practical lifestyle tools every person can use to reset their health. She is the host of one of the leading science podcasts, The Resetter Podcast, and the author of three best-selling books; The Menopause Reset, The Reset Factor, and The Reset Kitchen. Dr Pelz' transition from Chiropactor to Functional Medicine Practitioner was ultimately triggered 10 years into her career as she started to realize that people were unable to heal due to their environment. Key Takeaways: 2:19 Hitting menopause ultimately drove Dr Pelz to start digging into what exactly is happening to women in this transition and, more importantly, that finding a solution was going to have to come from her...not her doctor, not a pill. 7:10 The external influences - like makeup, processed foods, anxiety that affect women's hormonal cycles 7:46 The beauty of women's hormones….and how staying in sync with these hormones can help us to make the most of them 8:21 How something as simple as seed cycling can help to support hormonal balance 10:35 What foods to eat at different times of your cycle to support your hormones so that you can look, feel and perform your best… 11:03 Day 1-Day 10 the perfect time to fast, go Keto or push yourself a little harder. 11:41 Day 11-Day15 this is the time to BUILD muscle and support your microbiome.."bathe yourself in sauerkraut" Day 15-20 it's back to Keto, fasting etc…. 12:55 Day 20 is when you get to chill out...progesterone support is now the priority and healthy carbs are the name of the game… 13:36 How and why the Ketogenic Diet can backfire for many women 16:21 Helping women to take back their power over their health 19:49 There are two types of the energy system: sugar burner energy system and fat burner energy system 21:14 By doing sugar burner energy source should avoid preservative foods 34:19 Forty years old and above should eat more leafy foods for estrogen wealth 38:11 Doing HRT is best to complement a healthy lifestyle 45:32 Menopause has a different outlook on every other woman not like the standard perception 52:35 Oxytocin is an anabolic and major key in hormone growth 01:02:22 Dry fasting benefits will get us to deeper ketosis but should be under 24hrs fasting period only Linkage: The Menopause Reset book Master Amino acid Pattern Jason's Fung Book's Connect: Website: www.drmindypelz.com Dr Pelz YouTube channel Disclaimer: Please note that this podcast is for information purposes only. None of the content is intended as medical advice – before undertaking any new health initiative be it a change in diet, lifestyle or supplementation please consult with your medical practitioner.

5 Apr 20211h 15min

Dr Amy Killen, anti-aging and regenerative medicine physician specializes in beautifying skin and sexual rejuvenation. In this episode we talk about how she made the unlikely transition from emergency medicine to the field she is in today and the many ways that she is able to now support her patients to better overall health through the lens of improving skin and sexual health. She is Board Certified in Emergency Medicine with more than ten years of direct patient care, practicing Anti-Aging and Regenerative Medicine for more than five years and an advocate for empowering patients to look and feel their best by merging lifestyle modification, hormone optimization, personalized medicine and regenerative therapies. Meet this week's guest: Dr. Amy Killen MD is an anti-aging and regenerative physician specializing in sexual optimization and aesthetics. An international speaker, teacher, author and clinical practice owner, Dr. Killen is an outspoken advocate for empowering patients to look and feel their best by merging lifestyle modification, hormone optimization, personalized medicine, and regenerative therapies. Key Highlights: [06:19] Her discovery and interests in the field of regenerative medicine [07:24] What is PRP or Platelet-rich plasma? [10:20] Differences between stem cells and plasma [22:37] The ideal age to start taking peptides and other facial rejuvenation procedures [22:49] Different strategies to rejuvenate your face and skin [26:43] Peptides for Anti Aging and Rejuvenation [34:15] Alternative therapies for erectile dysfunction [39:57] Who is easier to treat a woman or man? [46:22] The uses and classification of supplements [47:49] Shockwave Therapy works as does PRP which helps for erectile dysfunction Linkage: PRP Shockwave Therapy Connect : Instagram Twitter Facebook Website Youtube

29 Mar 20211h 7min

As Dr Yurth says: Osteoarthritis is not a "you've run too many miles" problem - it is a disease process that may be avoided altogether if caught early enough and treated if addressed properly. We explore the many ways that this debilitating condition can be addressed including some of the strategies that Dr Yurth uses in her clinic with her patients - we talk about peptides, addressing underlying causes and a few powerful supplements that can make a real difference. Meet this week's guest: Dr. Elizabeth Yurth, MD is the Founder and clinical director of the Boulder Longevity Institute in Boulder Colorado. Her specialties include Orthopaedic Surgery, Physical Medicine & Rehabilitation, Sports Medicine, Longevity and Regenerative Medicine. Dr. Yurth is Board Certified in Anti-Aging Medicine, has her advanced Fellowship Training in Anti-Aging Medicine, is a Member of the American Academy of Anti-Aging Medicine. She is also a faculty member of the SSRP - Seeds Scientific Research and Performance Mastermind. Key Highlights: [1:01] Why Dr. Yurth left the Orthopedic Practice she helped to Co-Found 27 Years ago [3:21] Why arthritis gets pushed to the background of chronic preventable diseases [5:44] Where senescent cells come into play in joint health [6:17] Where inflammation comes into play in the development of arthritis [7:21] A study on mice that may highlight the link between interleukin 1 Beta + the development of arthritis [9:00]Why steroids injected into an inflamed joint is a bad play for the long term [9:50] The loss of cytokines as part with the downward spiral into disability in advancing age [11:46] Why exercising remains a priority even when injured [12:46] Study on Rheumatoid Arthritis + movement vs. rest [13:10] the link between ACL reconstruction + arthritic knees and how EGCG may be able to help [14:35] Pentosan Polysulphate's place in post surgical recovery [15:30] How Pentosan Polysulphate works and on how it studies [18:20] The difference between the oral version of PP(Elmoron) and the injectible [20:39] Where to get PP and why just using veterinary products on humans may not be a great idea [21:59] AOD9604+ Pentosan Polysulphate + Hyaluronic Acid [23:41] Pentosan Polysulphate after surgery [24:06] How to offset the High levels of certain inflammatory nucleays can reduce the efficiency of stem cell treatments [28:55] Dr. Yurth on Red Light Therapy [33:58] What Dr. Yurth does to block inflammation Pentosan, EGCG, Melatonin [34:22] High dose Melatonin as an anti-inflammatory [35:52] High Dose of Melatonin for Septic Babies [37:00] Epigallocatechin (EGCG) and Spermidine for the win! [37:52] EGCG Pre workout to increase muscle growth Myostatin Follistatin. EGCG under 4 grams/day may bump liver enzymes in some people. 1 gram/day maintenance increase in disease states [39:07] Spermidine + Osteoarthritis [41:25] Some helpful info for Post Covid Recovery [43:57] Addressing Acidic States - Alka Seltzer Gold Linkage: Cytokines ACL Injury Aod 9604 Human Optimization Academy Connect with Dr. Yurth: Boulder Longevity Institute Linkedin Instagram: @dryurth

23 Mar 20211h

This episode is the second of a two-part series on Primeadine: a new healthy aging Spermidine supplement that is already getting rave reviews. Spermidine is a potent polyamine, known for inducing autophagy or cellular renewal. As we age, our bodies are getting slower and slower in the production of spermidine leaving us more reliant on exogenous sources be they food or supplementation. Supplementation with spermidine in humans has been shown to support cognition and heart health, balance hormones and improve hair growth and fullness (including eyelashes), strengthening nails. Spermidine also positively impacts five of the nine hallmarks of aging including: misfolded proteins (impaired proteostasis), epigenetic changes, mitochondrial dysfunction, stem cell dysfunction, impaired cellular communication. Amy Lamotte is a fellow biohacker and in this episode, she shares her amazing hacks and simple and effective techniques that anyone can follow. We talk about the benefits of Spermidine, its mechanisms, and how it induces autophagy. She also shares about how she hacked her autoimmune disease, treating it and reversing it herself through diet, supplementation and testing. You shouldn't miss this episode. Listen in! Meet this week's guest: Amy Lamotte is the Managing Director of Vallotte Nutrigenomics Limited in Hong Kong. She is a clinical nutritionist and researcher specializing in personalized nutrition, nutritional biochemistry, nutrigenetics, and nutrigenomics. Other areas of interest include anti-aging, circadian biology, and the microbiome. She has a Master's of Science in Human Nutrition (summa cum laude) from the University of Bridgeport and a J.D. from Yale Law School. Key Highlights: [13:38] The mechanisms of Spermidine [06:05] What is autophagy and why is it important? [19:41] The influence of Spermidine levels in different age groups [22:12] Different factors and theories in dysregulation of spermidine [25:07] Diet has a big effect on preventive healthcare [26:50] The two great powerful combo - diet and supplements [31:35] What are the best supplements to take and not to take? [34:53] There are two types in human studies: epidemiological studies and clinical trials [38:44] The human clinical study of spermidine and the after results Linkage: Oxford Healthspan (Use promo code BIONAT15 to save 15% off your order.) Connect with Amy: Instagram: @amylamotte Linkedin: https://www.linkedin.com/in/amy-valley-lamotte-501676111/ Website: https://www.amylamotte.com/ Promo code: Bionat15 for 15% off for your full order To Try Primeadine: Primeadine.com REFERENCES FROM PODCAST INTERVIEW: REVIEW ON DIETARY & GUT MICROBIOTA POLYAMINES Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019). Dietary and gut microbiota polyamines in obesity-and age-related diseases. Frontiers in nutrition, 6, 24. EPIDEMIOLOGICAL STUDIES RE SPERMIDINE/POLYAMINES Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., ... & Madeo, F. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature medicine, 22(12), 1428-1438. Kiechl, S., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., ... & Willeit, J. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American journal of clinical nutrition, 108(2), 371-380. Pucciarelli, S., Moreschini, B., Micozzi, D., De Fronzo, G. S., Carpi, F. M., Polzonetti, V., ... & Napolioni, V. (2012). Spermidine and spermine are enriched in whole blood of nona/centenarians. Rejuvenation research, 15(6), 590-595 Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020). Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. NeuroImage, 221, 117132. Soda, K., Kano, Y., & Chiba, F. (2012). Food Polyamine and Cardiovascular Disease-An Epidemiological Study. Global journal of health science, 4(6), 170. HUMAN TRIALS RE SPERMIDINE Pekar, T., Bruckner, K., Pauschenwein-Frantsich, S., Gschaider, A., Oppliger, M., Willesberger, J., ... & Jarisch, R. (2020). The positive effect of spermidine in older adults suffering from dementia. Wiener klinische Wochenschrift, 1-8. Schwarz, C., Stekovic, S., Wirth, M., Benson, G., Royer, P., Sigrist, S. J., ... & Flöel, A. (2018). Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY), 10(1), 19. Wirth, M., Benson, G., Schwarz, C., Köbe, T., Grittner, U., Schmitz, D., ... & Flöel, A. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex, 109, 181-188. IN VIVO STUDY RE MICROBIAL SPERMIDINE PRODUCTION & BONE Chevalier, C., Kieser, S., Çolakoğlu, M., Hadadi, N., Brun, J., Rigo, D., ... & Trajkovski, M. (2020). Warmth prevents bone loss through the gut microbiota. Cell metabolism, 32(4), 575- 590. POLYAMINES/SPERMIDINE IN FOOD Handa, A. K., Fatima, T., & Mattoo, A. K. (2018). Polyamines: bio-molecules with diverse functions in plant and human health and disease. Frontiers in chemistry, 6, 10. Kandasamy, S., Yoo, J., Yun, J., Kang, H. B., Seol, K. H., & Ham, J. S. (2021). Quantitative Analysis of Biogenic Amines in Different Cheese Varieties Obtained from the Korean Domestic and Retail Markets. Metabolites, 11(1), 31. Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-1584. SEX DIFFERENCES RE EXERCISE & AUTOPHAGY INDUCTION Escobar, K. A., Welch, A. M., Wells, A., Fennel, Z., Nava, R., Li, Z., ... & Mermier, C. M. (2020). Autophagy response to acute high-intensity interval training and moderate-intensity continuous training is dissimilar in skeletal muscle and peripheral blood mononuclear cells and is influenced by sex. Human Nutrition & Metabolism, 200118.

17 Mar 20211h 6min

In this episode, Dr. Misak and I talked about how bioelectric chemistry changes our bodies and how to optimize personal energy efficiency. He has developed a fascinating system to give each of his patients insight into how their body works, based on bioelectric chemistry that effectively reads the body metrics, and then conveys individual deficiencies. Let us welcome him on this podcast as he unravels the chemistry and optimization of the human body. At the end of the episode we talk about a new antiaging supplement that Dr. Misak formulated that is getting rave reviews from his patients - after 3 years of development he has launched Vi-Telometry a unique & eclectic herbal formula that supports and possibly even restores telomeres! Dr Misak generously has provided a 10% discount for listeners who want to try Vi-Telometry for themselves: BIONAT10 https://vitelometry.com/ Meet this week's guest: Darrell S.C.S. Misak, ND, RPh - Doctor of Naturopathic Medicine, Licensed Pharmacist is a father of five healthy children and the creator of VI-Telometry. After receiving his Bachelor of Science degree in Pharmacy from West Virginia University in 1992, he gained 3½ years of university hospital pharmacy experience at Duke University Medical Center. During his hospital pharmacy experience, Dr. Misak's primary focus was clinical rounding in Oncology and General Medicine. As he began to realize the pitfalls of traditional medicine and pharmacy, he started his continued search for truth in health, which directed him to naturopathic medicine. Key Highlights: 03:07 Basic principles of how the body restores itself06:11 The five phases of health 08:53 Symptoms of poor sugar regulation 10:35 Cause and effect of deficiencies 12:43 How bioelectric chemistry can read the symptoms 14:32 Dr. Misak's Youtube journey 18:21 Metrics identifying the needed nutrition 22:00 Knowing your body better 25:21 People's testimonials about Vi-Telometry Dr Misak's Longevity supplement 28:24 The ingredients in Vi-Telometry 37:00 Growing food that will nourish the body - it goes beyond adding Phosphorus, Nitrogen & Potassium to the soil 39:00 Feeding soil to create nourishing food -the difference between organic and biodynamic food Linkage: Restoration of the Human Organism through Concentration on Numbers Hyperbaric oxygen therapy VI-Telometry Carey Reams Connect with Dr Misak: Website: https://vitelometry.com/ Dr Misak: https://vitelometry.com/pages/meet-dr-misak To try the Vi-Telometry Supplement: https://vitelometry.com/ Use promo code BIONAT10 for 10% off

11 Mar 202148min

In this episode, we meet Shawn Wells, the author of The Energy Formula, his new book that covers pretty much every aspect of health optimization you can think of - from nutrition to supplementation, sleep optimization to the people you surround yourself with and, most importantly, the inner work and healing we must take on to achieve truly show up as our best selves. Shawn also shares his incredible health journey, how he came to love himself on his way to a healthy lifestyle, and the many challenges he had to overcome along the way. As a master formulator, Shawn takes us on a deep dive into choosing the right supplements that can improve health and vitality while introducing us to some little-known compounds that are sure to be game changers in metabolic health. Meet this week's guest: Shawn Wells MPH, LDN, RD, CISSN, FISSN is the world's leading nutritional biochemist and expert on Health Optimization. He has been dubbed the "World's Great Formulator" of nutritional supplements. Shawn is a popular speaker and has been featured on over 150 podcasts, in documentaries and on TV segments. He has also written for numerous magazines, blogs and websites. Key Highlights: Shawn's personal health journey and how it shaped his career choice early on. [21:39] Shawn's unique take on what Biohacking means to him [30:57 ] What's in a name - breaking down the name of Energy Formula Book [36:41 ] The After-effects of stress on our body and their different types [43:10] Resiliency in our body critical for our well being [45:29] People that are closed to you have the biggest effect on our lives and how give-and-take should manifest in every relationship [49:13 ] This is the part where we dive into the book, supplementation etc...DiHydroBerberine, L Baiba, Grains of Paradise…. Connect with Shawn Wells: Shawn Wells Shawn Wells on Instagram Buy the Book!!! https://www.energyformula.com

4 Mar 20211h 23min

Dr Siobhan Newman is a fellow of Dr William Seed's SSRP (Seed's Scientific and Research Performance) Mastermind - a growing group of physicians specializing in practicing lifestyle and regenerative medicine using, among many other things, peptides. Dr Newman spent 20 Years as a Board-certified Emergency Room Dr. until she decided it was time to help patients actually reclaim their health and vitality. She is co-founder and Chief Medical Officer of Newman MD Lifecare in Southern California. Our conversation covers the span of her philosophy of caring for her patients and how she integrates peptides, lifestyle management and bioidentical hormone therapy to help her patients reclaim their health and vitality. Meet this week's guest: Dr. Siobhan Newman is board certified in Emergency Medicine and Family Medicine, specializes in Emergency Medicine. Dr Newman has also acquired advanced certifications in Bio-Identical Hormone Therapy and Peptide Therapy - the latter through the A4M. She is affiliated with Hollywood Presbyterian Medical Center and Good Samaritan Hospital and is Co-Founder and Chief Medical Officer at Newman MD LifeCare. Key Highlights: From Emergency Room medicine to regenerative and lifestyle practice….what made it happen? Going "back to school", learning about ways to support the body, from lifestyle to nutrition, hormones and the discovery (and study) of peptides Healing the body from the inside out The importance of symptoms over (or with testing) when assessing hormone function & balance The role of and source of toxins in inflammation and disease - addressing them through detoxification and reduced exposure Where/when do peptides fit into a protocol? Hormone replacement/optimization for people in advanced years (70's and 80's) (27:00) Dr Newman's top peptides in practice… (32:00) Optimizing the immune system with peptides.. (36:00) Using peptides in cycles and in stacks….addressing cell cycles, cellular senescence, etc. Linkage: BPC 157 Thymus alpha 1 AOD 9604 Connect with Dr Siobhan Newman: admin@NewmanLifecare.com Linkedin NewMan MD Lifecare

1 Mar 202154min

In this episode, Part 2 of the Biostrap EVO series, we get the perspective of Biostrap's Chief Science Officer - Kevin Longoria on the Biostrap technology, some of the clinical studies using it and how to apply some of the metrics to your health journey. Kevin and I continue the conversation about how the Biostrap EVO could be an essential tool for Biohackers looking for clinical grade data that they can trust. We go deeper into a new metric - arterial age and elasticity and how it may turn out to be a powerful way to assess and monitor cardiovascular health. This episode has a lot of great insights! Listen in. Meet this week's guest: Kevin Longoria is an expert in the field of Clinical Physiology with an emphasis on cardiopulmonary and nervous system-based approaches to optimizing health and athletic performance. His previous role is a Chief Science Officer (CSO) for a progressive neuroscience company. He is currently a Clinical Exercise Physiologist and the Chief Science Officer at Biostrap. To buy a Biostrap: Biostrap.com To save 10% use promo code Longevity10 Key Highlights: 01:51 How Kevin found the Biostrap and ultimately became their Chief Science Officer 03:34 Biostrap is adapting through generations 05:46 What are the limitations of Biostrap? 07:58 What are the reading specifications of Biostrap? 08:28 Understanding Arterial Age 10:20 The ideal metrics for humans 12:14 The Biostrap data checking process 15:42 The most important metrics for people 23:52 How meditation reflects data 27:13 Wearable technology and Covid research 29:16 Covid intervention 33:42 Biometrics trigger indicators 40:51 Ideal sleeping pattern routine Linkage: Patrick McCown's book, The Oxygen Circadian Pattern Photoplethysmography Connect with Kevin: Website: biostrap.com Linkedin: https://www.linkedin.com/in/kevin-longoria-2b581b164/

26 Feb 202158min