Haemophilia B, Gene Therapy
Feedback Timestamps to follow! 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists ...
11 Apr 50min
Dilemmas in Haemophilia
Feedback This is a discussion about possible factors and strategies to consider and should not be used as a guideline for clinical practice. Always discuss complicated cases with the attending H&T con...
8 Feb 43min
Acquired Haemophilia A
Feedback 00:52 Intro and chuckles 01:40 Case study: 75M, left calf swelling, put on DOAC, 24 hrs later haematoma and deep bleed on CT 06:00 General information Elderly (>65), Mortality 8-40%Common pre...
25 Jan 42min
Haemophilia A in Pregnancy
Feedback 00:52 Intro - very important topic 02:00 Case Study: Haem/Obstetrics clinic, Family Hx Severe Haemophilia A, 12wks pregnant 04:15 Clotting changes in pregnancy Increased: FVII, FVIII, FX, VWF...
11 Jan 50min
Haemophilia A: Inhibitors
Feedback 00:52 Intro 02:10 Definition Common: Alloantibody neutralizes FVIIIRare: causes increased clearance of FVIII1/3 of Severe Haemophilia A patientsMedian time 10-15 emergency dosesRF: Mutation t...
30 Nov 202553min
Haemophilia A: Management Basics
Feedback 00:52 Intro 02:35 Structure of Haemophilia A care 05:10 Key aspects of management (On-demand vs prophylaxis) 07:00 Prophylaxis: reduce death rates from ICH and reducing joint bleeds - Primary...
16 Nov 20251h 24min
Haemophilia A: Diagnosis & Investigations
Feedback 00:52 Intro 02:00 What is Haemophilia A? 03:00 Factor VIII, Pathogenesis of Haemophilia A 07:10 Structure of Factor VIII (exam pearl) 300kDHeavy (A1 A2, B) + Light Chain (A3, C1, C2) bound by...
9 Nov 202549min
Factor XIII (13), Fibrinolysis & Thrombolysis
Feedback 01:45 Case: Neonate with repeated umblical bleeding. IC haemorrhage. Normal Factors (so far), Normal VW screen, Normal FBC and normal film. 05:35 Factor XIII (13): function and presentations...
12 Jul 202546min
