#390: Muscle, Mitophagy, and Longevity: How Urolithin A Supports Healthy Aging and Athletic Performance With Brad Currier, PhD

Today, I'm joined by Dr. Brad Currier, Manager of Clinical Trials at Timeline Nutrition and an expert in the world of muscle and aging research. Brad is on the cutting edge of mitochondrial science, and in this episode, he helps us unravel the mysteries of why some 80-year-olds are still crushing it in the gym while others struggle to get up the stairs. We dive into his fascinating research on mitophagy—our bodies' system for recycling dysfunctional mitochondria—and what it means for muscle health, strength, and vibrant aging. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Episode Timestamps: Episode start … 00:00:00 What is Mitophagy? Why It Matters as We Age ... 00:04:53 Mitophagy in Athletes vs. General Population ... 00:07:15 Urolithin A and Why Most People Can't Make It ... 00:12:12 What Mitopure Does: Mitophagy and Biogenesis ... 00:24:10 Key Study: Strength Gains in Middle-Aged Adults ... 00:26:43 Dose Guidance: 500mg vs. 1g ... 00:31:39 Anti-Inflammatory Effects and Immune Health ... 00:33:07 Benefits Beyond Muscle: Skin, Immunity, Brain ... 00:35:01 Weightlifter Study: Performance in Trained Athletes ... 00:40:34 Mitopure for Recovery and User Experiences ... 00:46:41 How to Use Mitopure: Timing, Dosage, Consistency ... 00:52:54 Protein, Creatine, and Mitopure: The Basics Stack ... 00:53:41 Recovery, Cycling, and How Soon Benefits Appear ... 00:58:44 Debunking Myths: Pomegranate, Antioxidant, Athletes Only ... 01:10:26 Mitopure vs. Generic Urolithin A: Safety Concerns ... 01:13:39 Our Amazing Sponsors: Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit wizardsciences.com and use code NAT15 for 15% off. Sleep smarter, not harder. Tro Mune by Troscriptions - Cold season doesn't have to take you out. I use Tro Mune—a nightly buccal troche with 75 mg cordycepin—to build immune resilience while I sleep. Take ½–1 before bed, and use it before you get sick or right when you feel it. Troscriptions.com, use NAT10, and get 10% off your first order. Thymus & Pineal BioRegulators - The Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. The Pineal Bioregulator supports your natural melatonin/circadian rhythm—key when schedules and daylight change—so you get the kind of sleep that underpins immune resilience. Head to profound-health.com and use code LONGEVITY15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group