#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!

This episode is brought to you by:

Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://Qlosi.com/Tim

David Protein Bars with 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/Tim (Buy 4 cartons, get the 5th free.)

Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $400 off your very own Pod 5 Ultra)

Coyote the card game​, which I co-created with Exploding Kittens: https://coyotegame.com

Timestamps:

  • [00:00:00] Start.
  • [00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
  • [00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
  • [00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
  • [00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
  • [00:33:12] DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
  • [00:41:21] Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
  • [00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
  • [00:49:40] Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
  • [00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
  • [00:58:05] Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
  • [01:02:05] Holiday gift ideas and recommended reading.
  • [01:17:41] The Way App and meditation with Zen master Henry Shukman.
  • [01:21:44] Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
  • [01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
  • [01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
  • [01:38:17] Terry Real's relationship wisdom: Why objective reality has no place in an argument.
  • [01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
  • [01:47:58] Parting thoughts and happy holidays.

*

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Avsnitt(862)

#842: The Story Behind EpiPen, The Rise of Food Allergies, and What Doctors Got Wrong

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#841: Arthur Brooks — Finding The Meaning of Your Life, The Poet's Protocol, The Holy Half-Hour, and Why Your Suffering is Sacred

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#839: Dr. Fei-Fei Li, The Godmother of AI — Asking Audacious Questions, Civilizational Technology, and Finding Your North Star

#839: Dr. Fei-Fei Li, The Godmother of AI — Asking Audacious Questions, Civilizational Technology, and Finding Your North Star

Dr. Fei-Fei Li (@drfeifei) is the inaugural Sequoia Professor in the Computer Science Department at Stanford University, a founding co-director of Stanford’s Human-Centered AI Institute, and the co-fo...

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#837: How to Simplify Your Life in 2026 — New Tips from Derek Sivers, Seth Godin, and Martha Beck

#837: How to Simplify Your Life in 2026 — New Tips from Derek Sivers, Seth Godin, and Martha Beck

As we head into the new year, many of us feel like we’re drowning in invisible complexity. So I wanted to hit pause and ask a simple question: What are 1-3 decisions that could dramatically simplify m...

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#836: The 4-Hour Workweek Principles — 13 Mistakes to Avoid, The Art of Mini-Retirements, and Navigating the Dizziness of Freedom

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Ben Patrick, better known as “Kneesovertoesguy” (@kneesovertoesguy), is the founder of Athletic Truth Group (ATG), an online and brick-and-mortar training system rooted in rehabilitative strength and ...

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