#386 - 🟱 HOT TOPICS 2025 COVERAGE - Should Every NICU Patient Receive Genomic Sequencing?
The Incubator9 Dec 2025

#386 - 🟱 HOT TOPICS 2025 COVERAGE - Should Every NICU Patient Receive Genomic Sequencing?

Send us Fan Mail Dr. Pankaj Agrawal, Division Chief of Neonatology at University of Miami, discusses rapid genomic advances—from six-month diagnostic timelines in 2000 to same-day sequencing today. While current practice targets phenotype-based testing for unexplained conditions or dysmorphic features, Agrawal advocates moving toward universal NICU sequencing to identify previously unrecognized conditions. Key barriers include administrative buy-in, cost concerns, consent processes, and resul...

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#458 - 📑 Journal Club - The Complete Episode from August 15th 2026

#458 - 📑 Journal Club - The Complete Episode from August 15th 2026

Send us Fan Mail The full week of Journal Club in one place. Monday, the PLaNT trial of prophylactic CPAP for late preterm infants born by cesarean, with senior author Dr. Edgardo Szyld. Tuesday, whet...

15 Aug 2h

#458 - [Journal Club] - 📌 Can the respiratory severity score show us where a baby is heading?

#458 - [Journal Club] - 📌 Can the respiratory severity score show us where a baby is heading?

Send us Fan Mail The respiratory severity score is one multiplication most of us already do in our heads, mean airway pressure times FiO2. This week Dr. Dinushan Kaluarachchi joins Journal Club to wal...

14 Aug 26min

#458 - [Journal Club] - 📌 Could a handheld light probe detect NEC before the X-ray does?

#458 - [Journal Club] - 📌 Could a handheld light probe detect NEC before the X-ray does?

Send us Fan Mail NEC still tends to announce itself on an X-ray, usually later than we want. This week Daphna reviews the first-in-human study of broadband optical spectroscopy, a handheld transcutane...

13 Aug 22min

#458 - [Journal Club] - 📌 Is this the trial that brings probiotics back to the NICU?

#458 - [Journal Club] - 📌 Is this the trial that brings probiotics back to the NICU?

Send us Fan Mail Probiotics left US NICUs after the FDA reclassified them, and NEC rates went up. This week Ben reviews the Connection Study, a 2,158 infant phase 3 trial of IBP-9414, a live biotherap...

12 Aug 26min

#458 - [Journal Club] - 📌 Does holding during cooling change NICU outcomes in HIE?

#458 - [Journal Club] - 📌 Does holding during cooling change NICU outcomes in HIE?

Send us Fan Mail Parents of babies undergoing therapeutic hypothermia often wait days before they can hold their child, and many never get the chance during cooling at all. This week on Journal Club, ...

11 Aug 18min

#458 - [Journal Club] - 📌 Should late preterm infants born by cesarean receive prophylactic CPAP?

#458 - [Journal Club] - 📌 Should late preterm infants born by cesarean receive prophylactic CPAP?

Send us Fan Mail Late preterm babies born by cesarean fill our NICUs, and most of them are there for respiratory distress that resolves in a day or two. Could 20 minutes of CPAP in the operating room ...

10 Aug 36min

#457 - Are We Rethinking When and How We Give Surfactant (ft Dr. Roger Soll)

#457 - Are We Rethinking When and How We Give Surfactant (ft Dr. Roger Soll)

Send us Fan Mail When is surfactant "early," and when is it too early, or too late? In this second installment of our two-part series with the Neonatal Resuscitation Symposium, Ben Courchia sits down ...

3 Aug 34min

#456 - 📑 Journal Club - The Complete Episode from August 1st 2026

#456 - 📑 Journal Club - The Complete Episode from August 1st 2026

Send us Fan Mail Which babies with critical congenital heart disease face the highest risk of brain injury, and does earlier surgery actually help? Why is infant CHD mortality climbing again after yea...

1 Aug 1h 13min

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