The Curbsiders Internal Medicine Podcast15 Dec 2025

#508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies

Master cardiovascular disease prevention! Learn how to apply the new PREVENT risk calculator, use the CPR framework for risk reclassification, and interpret ApoB and Lp(a) in modern lipid management. We’re joined by Dr. Laurence Sperling to break down what’s new in ASCVD risk assessment and prevention.

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Show Segments

Intro
Case 1 from Kashlak
Risk assessment framework
ApoB and Non-HDL cholesterol
Lipoprotein(a) and its importance
The PREVENT risk score and its implications
Statins and other lipid lowering therapies
The role of diet and lifestyle in lipid management
Case 2 from Kashlak
Familial Hypercholesterolemia diagnosis and management
Key takeaways
Outro

Credits

Producer, Writer, Shownotes, Infographic, and Cover art: Ben Furman, MPH
Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP
Reviewer: Leah Witt, MD
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Technical Production: PodPaste
Guest: Laurence Sperling, MD

Disclosures

Dr. Sperling reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.

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