EPISODE 19: Scent for Survival – How Parasite Worms Track Us by CO₂

EPISODE 19: Scent for Survival – How Parasite Worms Track Us by CO₂

In this episode, we track how Strongyloides stercoralis — a human-infective nematode — uses carbon dioxide sensing to navigate both outside and inside its host. This tiny parasite shifts its response to CO₂ depending on life stage: repelled when searching for a host, but attracted once inside.


We explore:


  • Life-stage-specific behaviour: iL3s flee CO₂, iL3as chase it

  • How Ss-BAG neurons detect CO₂ via the Ss-GCY-9 receptor

  • CRISPR-generated mutants that lose their ability to sense CO₂

  • A new method for creating stable knockout lines in S. stercoralis

  • How CO₂ helps worms navigate through the bloodstream, lungs, and gut during infection



📖 Based on the research article:

“Carbon dioxide shapes parasite-host interactions in a human-infective nematode”

Banerjee et al., 2025, Current Biology

🔗 https://doi.org/10.1016/j.cub.2024.11.036



🎧 Subscribe to the WOrM Podcast for more full-organism discoveries in parasitism, behaviour, and neurobiology!


This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.


📩 More info:

🔗 ⁠⁠www.veerenchauhan.com⁠⁠

📧 veeren.chauhan@nottingham.ac.uk

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Avsnitt(53)

EPISODE 53: Worms on Pause

EPISODE 53: Worms on Pause

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EPISODE 52: Worms in Space: Microbiomes in a Capsule

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Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at a review with a bold idea.Can a tiny nematode help us protect fish, amphibians, reptiles and insects from an increasingly chall...

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Welcome to the next episode of the WOrM Podcast 🪱Today we’re talking about inheritance.Not DNA.Not small RNAs.Not epigenetics.But ribosomes.⸻🧬 The central ideaWhen mother worms experience dietary re...

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EPISODE 49: Glowing up the Worm Proteome

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Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at a paper that doesn’t answer a biological question.Instead, it builds the tools to answer thousands of biological questions in t...

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EPISODE 48: Murder Mode: How a Worm Evolved the Urge to Kill

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Welcome to the next episode of the WOrM Podcast 🪱Today we're talking about a worm with teeth.And a nervous system that has been rewired — by evolution — to become aggressive.⸻🧬 The central ideaPrist...

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EPISODE 47: When Bacteria Fight Back: Bioplastic Kills the Worm

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Welcome to the next episode of the WOrM Podcast 🪱Today we’re talking about something unexpected.A bioplastic — something we usually think of as sustainable, useful, even beneficial —can kill a worm.⸻...

29 Apr 21min

EPISODE 46: Turning in Time: Neural Sequences in the Worm Brain

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Welcome to the next episode of the WOrM Podcast 🪱Today we’re looking at something deceptively simple: a turn.But not just that a worm turns —how the brain decides to do it.⸻🧬 The central ideaTurning...

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