George Hotz: Comma.ai, OpenPilot, and Autonomous Vehicles

Vincent Racaniello is a virologist, immunologist, and microbiologist at Columbia. He is a co-author of the textbook Principles of Virology and co-host of This Week in Virology podcast. Please support this podcast by checking out our sponsors: - Privacy: https://privacy.com/lex to get $5 added to your account - Justworks: https://justworks.com - Sun Basket: https://sunbasket.com/lex and use code LEX to get $35 off - The Information: https://theinformation.com/lex to get 75% off first month - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil EPISODE LINKS: Vincent's Twitter: https://twitter.com/profvrr Vincent's YouTube: https://www.youtube.com/c/vincentracaniello Vincent's Podcast: https://www.microbe.tv/ Vincent's Website: http://www.virology.ws/ Vincent's Instagram: https://www.instagram.com/profvrr PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (10:24) - Microbiology by numbers (15:47) - From bacteria to an organism (23:46) - AlphaFold 2 (27:44) - Simulating an evolutionary arms race (53:11) - The most terrifying virus (1:14:54) - SARS-CoV-2 (1:29:38) - Coronaviruses and Influenza. What's the difference? (1:35:45) - Vaccines (1:41:43) - Lex on his reaction to the COVID-19 vaccine shot (1:47:39) - Modern vaccines (1:52:39) - How does mRNA vaccine work? (1:55:26) - Are mRNA vaccines safe? (2:21:52) - Lex on trust in authority (2:36:59) - Ivermectin (2:43:39) - Hydroxychloroquine (2:48:22) - Variants and mutations (2:55:20) - Testing (3:03:27) - How does COVID-19 spread? (3:06:37) - Masks (3:15:05) - Bret Weinstein vs Sam Harris (3:18:39) - This Week in Virology (3:28:19) - Advice for young people (3:30:42) - Meaning of life

1 Sep 20213h 35min

Wojciech Zaremba is a co-founder of OpenAI. Please support this podcast by checking out our sponsors: - Paperspace: https://gradient.run/lex to get $15 credit - Indeed: https://indeed.com/lex to get $75 credit - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Grammarly: https://grammarly.com/lex to get 20% off premium - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Wojciech's Twitter: https://twitter.com/woj_zaremba Wojciech's Website: https://wojzaremba.com/ OpenAI's Website: https://openai.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:57) - The Fermi paradox (14:59) - Systems of government (17:36) - Life, intelligence, and consciousness (24:49) - GPT language model (27:02) - Engineering consciousness (31:19) - Is there an algorithm for intelligence? (38:41) - Neural networks and deep learning (51:32) - Human reward functions (56:26) - Love is part of the human condition (58:53) - Expanding our circle of empathy (1:02:58) - Psychedelics and meditation (1:14:25) - Ilya Sutskever (1:21:42) - How does GPT work? (1:31:35) - AI safety (1:38:21) - OpenAI Codex (1:51:54) - Robotics (2:01:11) - Developing self driving cars and robots (2:12:02) - What is the benchmark for intelligence? (2:15:04) - Will we spend more time in virtual reality? (2:17:18) - AI Friendships (2:26:48) - Sleep (2:29:22) - Generating good ideas (2:35:47) - Advice for young people (2:40:31) - Getting started with machine learning (2:43:44) - What is beauty? (2:47:35) - Death (2:54:23) - Meaning of life

29 Aug 20212h 58min

Jed Buchwald is a historian and philosopher of science at Caltech. Please support this podcast by checking out our sponsors: - GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k - Theragun: https://therabody.com/lex to get 30 day trial - LMNT: https://drinkLMNT.com/lex to get free sample pack - Fundrise: https://fundrise.com/lex - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Jed's Caltech page: https://bit.ly/38eLLRF Jed's Books: https://amzn.to/2WoxGPi PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:34) - How does science progress? (22:48) - Theory of Everything (34:40) - Consciousness (38:15) - Most Beautiful Moments in Science (46:00) - Isaac Newton (1:12:13) - Competition in Science (1:22:47) - Newton's Career (1:35:58) - Importance of Data (1:42:17) - Alchemy (1:46:31) - Newton and Religion (1:49:44) - Showing Newton the future (1:54:28) - Newton and Einstein

27 Aug 20211h 58min

Barry Barish is a theoretical physicist at Caltech and the winner of the Nobel Prize in Physics. Please support this podcast by checking out our sponsors: - MUD\WTR: https://mudwtr.com/lex and use code LEX to get 5% off - GiveDirectly: https://givedirectly.org/lex to get gift matched up to $300 - BiOptimizers: http://www.magbreakthrough.com/lex to get 10% off - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Barry's Nobel Prize entry: https://www.nobelprize.org/prizes/physics/2017/barish/facts/ Barry's Caltech profile: https://pma.caltech.edu/people/barry-c-barish LIGO's Website: https://www.ligo.caltech.edu/ LIGO's Twitter: https://twitter.com/LIGO PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:27) - Early Math and Physics questions (18:02) - Enrico Fermi (24:34) - Birth of the Nuclear Age (29:42) - The Fermi Paradox (34:45) - Gravity (51:28) - Philosophical Implications of General Relativity (58:34) - Detecting Gravitational Waves (1:01:47) - LIGO (1:34:45) - Nobel Prize (1:49:34) - Black Holes (2:01:53) - Space Exploration (2:09:48) - Books (2:18:37) - Advice for young people (2:24:33) - Meaning of life

23 Aug 20212h 30min

Joscha Bach is a cognitive scientist, AI researcher, and philosopher. Please support this podcast by checking out our sponsors: - Coinbase: https://coinbase.com/lex to get $5 in free Bitcoin - Codecademy: https://codecademy.com and use code LEX to get 15% off - Linode: https://linode.com/lex to get $100 free credit - NetSuite: http://netsuite.com/lex to get free product tour - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Joscha's Twitter: https://twitter.com/Plinz Joscha's Website: http://bach.ai PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:15) - Life is hard (09:38) - Consciousness (16:24) - What is life? (26:33) - Free will (40:38) - Simulation (42:49) - Base layer of reality (58:24) - Boston Dynamics (1:06:43) - Engineering consciousness (1:17:12) - Suffering (1:26:06) - Postmodernism (1:30:25) - Psychedelics (1:43:40) - GPT-3 (1:52:22) - GPT-4 (1:58:47) - OpenAI Codex (2:01:02) - Humans vs AI: Who is more dangerous? (2:17:47) - Hitler (2:22:44) - Autonomous weapon systems (2:30:11) - Mark Zuckerberg (2:35:47) - Love (2:50:00) - Michael Malice and anarchism (3:06:57) - Love (3:11:05) - Advice for young people (3:15:42) - Meaning of life

21 Aug 20213h 18min

Brian Muraresku is the author of The Immortality Key. Please support this podcast by checking out our sponsors: - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k - NI: https://www.ni.com/perspectives - Indeed: https://indeed.com/lex to get $75 credit - MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Brian's Twitter: https://twitter.com/brianmuraresku Brian's website: https://www.brianmuraresku.com Immortality Key (book): https://amzn.to/3iNYBfB PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:46) - Who or what is God? (25:15) - Terence McKenna's DMT Trips (29:58) - Psychedelics were the source of collective intelligence (40:30) - Psychedelics in ancient alcohol (43:30) - The Immortality Key (46:16) - Jesus and psychedelic wine (58:56) - Role of rituals in human society (1:02:37) - Human confrontation with death (1:05:15) - The future of the human experience (1:17:07) - The role of religion in society (1:22:54) - The future of psychedelics research (1:26:05) - Fasting and meditation as religious experiences (1:29:44) - Neuralink and BCIs (1:36:42) - Is LSD a crutch or an aid in creative work (1:39:21) - Nietzsche said God is dead (1:41:48) - Creatures people meet while on psychedelics (1:47:18) - Consciousness (1:53:41) - Books or movies that made an impact (1:57:39) - Meaning of life

15 Aug 20210s

Matt Walker is a sleep scientist at Berkeley, author of Why We Sleep, and the host of a new podcast called The Matt Walker Podcast. Please support this podcast by checking out our sponsors: - Stamps.com: https://stamps.com and use code LEX to get free postage & scale - Squarespace: https://lexfridman.com/squarespace and use code LEX to get 10% off - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - BetterHelp: https://betterhelp.com/lex to get 10% off - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: Matt's Podcast: https://themattwalkerpodcast.buzzsprout.com/ Matt's Twitter: https://twitter.com/sleepdiplomat Matt's Instagram: https://www.instagram.com/drmattwalker Matt's Website: https://www.sleepdiplomat.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:56) - Putin moment: Lex takes Matt's sunglasses (10:17) - Fascination with sleep (14:26) - Why do we sleep? (22:58) - Computer vision for driver assistance (32:19) - Consciousness is fundamental (40:25) - Lex on human to robot connection (42:52) - Scent of a Woman is better than "John Wick" (54:33) - Distinction between coffee and caffeine (1:20:17) - The science of 'sleeping on it' (1:34:10) - Lex on his sleeping schedule (1:59:14) - Chronotypes (2:06:44) - How to overcome insomnia (2:24:07) - Diet and sleep (2:33:03) - Where do dreams come from? (2:46:41) - How sleep affects emotions (2:53:35) - Meaning of life

11 Aug 20210s

Luis and Joao Batalha are co-founders of Fermat's Library. Please support this podcast by checking out our sponsors: - Skiff: https://skiff.org/lex to get early access - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Indeed: https://indeed.com/lex to get $75 credit - NetSuite: http://netsuite.com/lex to get free product tour - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off EPISODE LINKS: Fermat's Library Twitter: https://twitter.com/fermatslibrary Luis's Twitter: https://twitter.com/luismbat Joao's Twitter: https://twitter.com/joao_batalha Fermat's Library Website: https://fermatslibrary.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (10:18) - Backstories to research papers (25:09) - Fermat's Library (45:10) - Scientific publishing (1:08:50) - How to read a paper (1:14:44) - Taking good notes (1:23:23) - Favorite papers on Fermat's Library (2:04:14) - Fermat's Library on Twitter (2:13:46) - What it takes to build a successful startup (2:22:43) - Game of Thrones (2:25:30) - Realism in science fiction movies (2:31:29) - Greatest soccer player of all time (2:54:18) - Advice for young people

9 Aug 20213h 2min