#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

John Vervaeke is a psychologist and cognitive scientist at University of Toronto. Please support this podcast by checking out our sponsors: - Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off - InsideTracker: https://insidetracker.com/lex to get 20% off - Eight Sleep: https://www.eightsleep.com/lex to get special savings - Athletic Greens: https://athleticgreens.com/lex to get 1 month of fish oil - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: John's YouTube: https://youtube.com/johnvervaeke John's Twitter: https://twitter.com/vervaeke_john John's Facebook: https://facebook.com/VervaekeJohn John's Website: https://johnvervaeke.com Books mentioned: Flow: https://amzn.to/3cQDby9 On Bullshit: https://amzn.to/3PZDvYW The Denial of Death: https://amzn.to/3KsIctp PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:03) - Meaning (27:17) - Consciousness (36:17) - Relevance realization (47:40) - Wisdom (54:54) - Truth (59:38) - Reality (1:11:59) - Meaning crisis (1:35:27) - Religion (1:43:17) - Nontheism (1:58:26) - Distributed cognition (2:16:37) - Flow (2:36:35) - Psychedelics (2:45:03) - Marxism and Nazism (2:57:08) - Evil (3:01:19) - Powerful ideas (3:08:10) - Advice for young people

4 Sep 20223h 17min

Noam Chomsky is a linguist, philosopher, and political activist. Please support this podcast by checking out our sponsors: - Skiff: https://skiff.com/lex - InsideTracker: https://insidetracker.com/lex to get 20% off - Onnit: https://lexfridman.com/onnit to get up to 10% off - Blinkist: https://blinkist.com/lex to get 25% off premium EPISODE LINKS: Noam's Website: https://chomsky.info/ Noam's Instagram: https://instagram.com/noam.chomskyofficial Manufacturing Consent (book): https://amzn.to/3KaEc0d PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:28) - Putin's motivations (20:35) - War in Ukraine (27:37) - Propaganda (35:01) - China and American relations (50:02) - Hope for humanity

31 Aug 202252min

Magnus Carlsen is the highest-rated chess player in history and widely considered to be the greatest chess player of all time. Please support this podcast by checking out our sponsors: - Shopify: https://shopify.com/lex to get 14-day free trial - Athletic Greens: https://athleticgreens.com/lex to get 1 month of fish oil - Fundrise: https://fundrise.com/lex - BetterHelp: https://betterhelp.com/lex to get 10% off - InsideTracker: https://insidetracker.com/lex to get 20% off EPISODE LINKS: Magnus's Twitter: https://twitter.com/MagnusCarlsen Magnus's Instagram: https://instagram.com/magnus_carlsen Magnus's YouTube: https://youtube.com/c/themagnuscarlsen Magnus's Website: https://magnuscarlsen.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:34) - Greatest soccer player of all time (15:40) - Magnus's approach to chess (24:53) - Game 6 of the 2021 World Chess Championship (28:54) - Chess openings (46:19) - Chess variants (49:04) - Elo Rating (57:31) - World Chess Championship (1:21:42) - Losing (1:29:04) - Day in the life (1:35:55) - Drunk chess (1:40:26) - Chess training (1:48:20) - Garry Kasparov (1:57:37) - Greatest chess player of all time (2:10:48) - Advice for chess players (2:12:32) - Chess YouTubers (2:16:03) - Henrik Carlsen (2:21:38) - Lessons for life (2:25:02) - Queen's Gambit (2:26:53) - Poker (2:33:06) - Loneliness (2:36:28) - How does the knight move?

27 Aug 20222h 39min

Liv Boeree is a poker champion and science educator on topics of game theory, physics, complexity, and life. Please support this podcast by checking out our sponsors: - Audible: https://audible.com/lex to get 30-day free trial - GiveWell: https://www.givewell.org and use code Lex Fridman Podcast - Linode: https://linode.com/lex to get $100 free credit - Indeed: https://indeed.com/lex to get $75 credit - ExpressVPN: https://expressvpn.com/lexpod to get 3 months free EPISODE LINKS: Liv's Twitter: https://twitter.com/liv_boeree Liv's Instagram: https://instagram.com/liv_boeree Liv's Facebook: https://facebook.com/livboeree Liv's YouTube: https://youtube.com/user/LivBoeree Books and resources mentioned: Novacene: https://amzn.to/3wcVqEo POSITIVITY: https://amzn.to/3K2pfxj Meditations on Moloch: https://slatestarcodex.com/2014/07/30/meditations-on-moloch PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:23) - Poker and game theory (13:26) - Dating optimally (18:18) - Learning (26:30) - Daniel Negreanu (31:38) - Phil Hellmuth (34:11) - Greatest poker player ever (38:29) - Bluffing (48:50) - Losing (58:05) - Mutually assured destruction (1:03:00) - Simulation hypothesis (1:19:38) - Moloch (1:48:50) - Beauty (2:00:58) - Quantifying life (2:21:08) - Existential risks (2:39:31) - AI (2:49:22) - Energy healing (2:56:32) - Astrophysics (2:59:26) - Aliens (3:25:08) - Advice for young people (3:27:13) - Music (3:35:02) - Meaning of life

24 Aug 20223h 41min

Jordan Peterson is a psychologist, lecturer, podcast host, and author. Please support this podcast by checking out our sponsors: - Notion: https://notion.com/startups to get up to $1000 off team plan - InsideTracker: https://insidetracker.com/lex to get 20% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings - Blinkist: https://blinkist.com/lex to get 25% off premium EPISODE LINKS: Jordan's Twitter: https://twitter.com/jordanbpeterson Jordan's Website: https://jordanbpeterson.com Jordan's Books: Beyond Order: https://amzn.to/3T4LRBw 12 Rules for Life: https://amzn.to/3c4sqYF Maps of Meaning: https://amzn.to/3A1Ods2 Websites mentioned: Essay App: https://essay.app Self Authoring: https://selfauthoring.com Peterson Academy: https://petersonacademy.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:07) - Dostoevsky (18:07) - God (26:17) - Science (38:40) - Death (41:34) - Elon Musk (45:32) - Global Crisis (57:45) - Dangerous ideologies (1:08:59) - Justin Trudeau (1:23:05) - War in Ukraine (1:40:33) - Day in the life (2:16:37) - How to think (2:31:45) - Depression (2:39:52) - Advice for young people (2:53:41) - Russian literature (3:05:29) - Meaning of life

19 Aug 20223h 10min

Duncan Trussell is a comedian, host of The Duncan Trussell Family Hour podcast, and co-creator of The Midnight Gospel. Please support this podcast by checking out our sponsors: - Skiff: https://skiff.com/lex - Calm: https://calm.com/lex to get 40% off premium - SimpliSafe: https://simplisafe.com/lex - NetSuite: http://netsuite.com/lex to get free product tour - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Duncan's Twitter: https://twitter.com/duncantrussell Duncan's Instagram: https://instagram.com/duncantrussell The Duncan Trussell Family Hour: https://duncantrussell.com The Midnight Gospel: https://netflix.com/themidnightgospel Books mentioned: Superintelligence: https://amzn.to/3QufVEs Man's Search for Meaning: https://amzn.to/3vU9S42 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:13) - Nietzsche's eternal recurrence (27:03) - Artificial intelligence (55:33) - Joe Rogan (1:04:06) - Facing death (1:20:54) - Bhakti yoga (1:27:46) - Afterlife (1:38:10) - Suffering (2:03:25) - War (2:21:19) - Depression (2:43:08) - Evil (2:53:24) - Burning Man (3:08:56) - The Midnight Gospel (3:13:48) - Advice for young people (3:23:19) - Duncan reads a poem

16 Aug 20223h 25min

Magatte Wade is an entrepreneur with a passion for creating positive change in Africa through economic freedom. Please support this podcast by checking out our sponsors: - Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off - Audible: https://audible.com/lex to get 30-day free trial - InsideTracker: https://insidetracker.com/lex to get 20% off - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: Magatte's Twitter: https://twitter.com/magattew Magatte's Instagram: https://instagram.com/magattew Magatte's Facebook: https://facebook.com/themagattewade Magatte's Website: https://magattewade.com Websites mentioned: Austin housing project: https://texansforreasonablesolutions.org Center for African Prosperity: https://atlasnetwork.org/partners/center-for-african-prosperity PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (05:55) - Africa (34:48) - Magatte's story (1:03:36) - Corruption (1:25:01) - Advice for young people (1:46:02) - Identity (2:06:58) - BLM (2:24:18) - CRT and racism (2:54:32) - African geopolitics (3:03:02) - Overpopulation (3:21:49) - Loss

13 Aug 20223h 38min

Andrew Bustamante is a former CIA covert intelligence officer. Check out his work and podcast at https://everydayspy.com Please support this podcast by checking out our sponsors: - Wealthfront: https://wealthfront.com/LEX to get $50 sign-up bonus - LMNT: https://drinkLMNT.com/lex to get free sample pack - BetterHelp: https://betterhelp.com/lex to get 10% off - ExpressVPN: https://expressvpn.com/lexpod to get 3 months free - MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Everyday Spy: https://everydayspy.com/quiz Everyday Spy Podcast: https://everydayspy.com/podcast Andrew's Twitter: https://twitter.com/everydayspy Andrew's Instagram: https://instagram.com/everydayspy PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:10) - CIA and the President (18:47) - War in Ukraine (59:44) - Most powerful intelligence agencies (1:06:54) - David Petraeus (1:16:31) - Undercover disguises (1:29:30) - Human nature (1:38:49) - CIA recruitment process (1:55:33) - CIA and secrecy (2:02:06) - Cyber security (2:12:47) - Sexpionage (2:19:22) - Private intelligence (2:32:48) - NSA and Snowden (3:00:48) - Conspiracy theories (3:21:55) - CIA and UFOs (3:36:41) - Spy tricks (3:53:23) - Advice for young people

8 Aug 20223h 59min