#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Michael Malice is a political thinker, podcaster, author, and anarchist. Please support this podcast by checking out our sponsors: - FightCamp: https://joinfightcamp.com/lex to get free shipping - Linode: https://linode.com/lex to get $100 free credit - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - Sunbasket: https://sunbasket.com/lex and use code LEX to get $35 off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Michael's Twitter: https://twitter.com/michaelmalice Michael's Community: https://malice.locals.com/ Michael's YouTube: https://www.youtube.com/channel/UC5tj5QCpJKIl-KIa4Gib5Xw Michael's Website: http://michaelmalice.com/about/ Your Welcome podcast: https://bit.ly/30q8oz1 Books & resources mentioned: The Anarchist Handbook (book): https://amzn.to/3yUb2f0 The New Right (book): https://amzn.to/34gxLo3 Dear Reader (book): https://amzn.to/2HPPlHS The Idiot (book): https://amzn.to/3zdHdHH Six-Word Memoirs (book): https://amzn.to/3zg51uv PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:07) - Truth, goodness, and beauty (19:35) - Save one life (26:26) - Jeffrey Epstein (45:21) - Jeffrey Epstein and Bill Clinton (51:33) - Christmas and New Years for Russians (58:14) - Russian cynicism and suffering (1:05:52) - Gift exchange (1:18:48) - Michael's move to Austin (1:24:14) - The Anarchist Handbook (1:30:46) - Ghislaine Maxwell (1:35:20) - Jeffrey Epstein (1:37:34) - Lex's move to Austin (1:46:21) - Elon Musk (1:49:31) - Writing The White Pill (1:54:18) - Camus (1:59:16) - Writing The White Pill continued (2:04:34) - New Year's resolutions (2:18:09) - 2024 elections (2:30:38) - National divorce (2:45:15) - Joe Rogan and Bret Weinstein vs Sam Harris (2:54:26) - Conversation with CEO of Pfizer (3:07:59) - Anthony Fauci (3:13:28) - Advice for young people (3:23:30) - Wife and kids (3:28:57) - Immortality

31 Dec 20213h 32min

Elon Musk is CEO of SpaceX, Tesla, Neuralink, and Boring Company. Please support this podcast by checking out our sponsors: - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - ButcherBox: https://butcherbox.com/lex to get offers & discounts - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - ROKA: https://roka.com/ and use code LEX to get 20% off your first order - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Elon's Twitter: https://twitter.com/elonmusk PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:38) - Elon singing (08:26) - SpaceX human spaceflight (15:12) - Starship (23:48) - Quitting is not in my nature (25:23) - Thinking process (34:56) - Humans on Mars (40:27) - Colonizing Mars (44:13) - Wormholes (48:50) - Forms of government on Mars (55:54) - Smart contracts (57:24) - Dogecoin (58:55) - Cryptocurrency and Money (1:05:04) - Bitcoin vs Dogecoin (1:07:47) - Satoshi Nakamoto (1:10:10) - Tesla Autopilot (1:13:16) - Tesla Self-Driving (1:25:19) - Neural networks (1:34:16) - When will Tesla solve self-driving? (1:36:19) - Tesla FSD v11 (1:43:53) - Tesla Bot (1:54:33) - History (2:02:24) - Putin (2:08:04) - Meme Review (2:22:29) - Stand-up comedy (2:24:03) - Rick and Morty (2:25:42) - Advice for young people (2:33:39) - Love (2:36:33) - Meaning of life

28 Dec 20212h 39min

Ray Dalio is an investor, author, and founder of Bridgewater Associates. Please support this podcast by checking out our sponsors: - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Ray's Twitter: https://twitter.com/RayDalio Ray's Instagram: https://www.instagram.com/raydalio Books & resources mentioned: Ray's books: https://amzn.to/3swN5uw Ray's free personality test: https://principlesyou.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:14) - Money or power (11:50) - Big Cycle (31:43) - Collapse of the American Empire (40:10) - War (43:18) - Xi Jinping (49:21) - Importance of freedoms (55:24) - Democracy's vulnerability (58:49) - Communism's vulnerability (1:05:50) - Vladimir Putin (1:09:55) - Understanding China (1:17:23) - Henry Kissinger (1:27:44) - Elon Musk and Dogecoin (1:29:41) - How to take notes (1:33:24) - Advice for young people (1:37:30) - Hope for humanity

25 Dec 20211h 40min

Peter Wang is the co-founder & CEO of Anaconda and one of the most impactful leaders and developers in the Python community. Also, he is a physicist and philosopher. Please support this podcast by checking out our sponsors: - Quip: https://getquip.com/lex to get first refill free - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Peter's Twitter: https://twitter.com/pwang Anaconda's Website: https://www.anaconda.com/ Books & resources mentioned: Zen and the Art of Motorcycle Maintenance (book): https://amzn.to/3EnCELK Lila (book): https://amzn.to/30VKIpE PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:49) - Python (10:20) - Programming language design (30:22) - Virtuality (40:22) - Human layers (47:21) - Life (52:45) - Origin of ideas (55:17) - Eric Weinstein (1:00:16) - Human source code (1:04:13) - Love (1:18:32) - AI (1:31:55) - Meaning crisis (1:54:28) - Travis Oliphant (2:00:53) - Python continued (2:30:36) - Best setup (2:37:54) - Advice for the youth (2:46:28) - Meaning of Life

23 Dec 20212h 53min

Albert Bourla is the Chairman and CEO of Pfizer. Please support this podcast by checking out our sponsors: - Notion: https://notion.com/startups to get up to $1000 off team plan - Calm: https://calm.com/lex to get 40% off - Hunter Douglas: https://www.hunterdouglas.com/lex to get a free design guide - LMNT: https://drinkLMNT.com/lex to get free sample pack - Grammarly: https://grammarly.com/lex to get 20% off premium EPISODE LINKS: Albert's Twitter: https://twitter.com/AlbertBourla Pfizer's Website: https://www.pfizer.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (10:08) - Clinical trials (26:12) - Trust (45:59) - Safety (56:16) - Booster shots (59:09) - Mandates (1:05:39) - Antivirals (1:10:38) - Hope for future

18 Dec 20211h 14min

Norman Naimark is a historian at Stanford, specializing in the history of genocide. Please support this podcast by checking out our sponsors: - Coinbase: https://coinbase.com/lex to get $5 in free Bitcoin - Quip: https://getquip.com/lex to get first refill free - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings - NetSuite: http://netsuite.com/lex to get free product tour - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Norman's Website: https://history.stanford.edu/people/norman-naimark Stalin's Genocides (book): https://amzn.to/3oO0Hzb Stalin and the Fate of Europe (book): https://amzn.to/3pLbWrk Books & resources mentioned: The Origins of Totalitarianism (book): https://amzn.to/3oNDSvA Man's Search for Meaning (book): https://amzn.to/3pMzs7d Radio Majdanek (Research Paper): https://bit.ly/3GxPEAb PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:08) - Stalin and absolute power (21:05) - Dictators and genocide (45:31) - What is genocide (55:38) - Human nature and suffering (1:25:23) - Mao's Great Leap Forward (1:32:37) - North Korea (1:36:30) - Our role in fighting against atrocities (1:45:26) - China (1:49:35) - Hopes for the future and technology (2:04:28) - Advice for young people (2:07:15) - Love and tragedy

13 Dec 20212h 25min

Jamie Metzl is an author specializing in topics of genetic engineering, biotechnology, and geopolitics. Please support this podcast by checking out our sponsors: - Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off - NI: https://www.ni.com/perspectives - GiveDirectly: https://givedirectly.org/lex to get gift matched up to $300 - Indeed: https://indeed.com/lex to get $75 credit - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium EPISODE LINKS: Jamie's Twitter: https://twitter.com/JamieMetzl Jamie's Website: https://jamiemetzl.com/ Jamie's lab leak blog post: https://jamiemetzl.com/origins-of-sars-cov-2/ Hacking Darwin (book): https://amzn.to/3lLqLsM PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:44) - Lab leak (1:06:18) - Gain-of-function research (1:15:49) - Anthony Fauci (1:25:31) - Francis Collins (1:30:13) - Joe Rogan, Brett Weinstein, and Sam Harris (2:00:10) - Xi Jinping (2:14:41) - Patient Zero (2:27:55) - WHO (2:51:45) - Government transparency (3:13:45) - Likelihood of a cover-up (3:15:34) - Future of reproduction (3:51:12) - Jon Stewart (3:56:31) - Joe Rogan and Sanjay Gupta (4:21:36) - Ultramarathons (4:31:38) - Chocolate (4:39:51) - One Shared World (4:54:54) - Hope for the future

8 Dec 20215h 1min

Peter Woit is a theoretical physicist, mathematician, critic of string theory, and author of the popular science blog Not Even Wrong. Please support this podcast by checking out our sponsors: - The Prisoner Wine Company: https://theprisonerwine.com/lex to get 20% off & free shipping - Linode: https://linode.com/lex to get $100 free credit - Sunbasket: https://sunbasket.com/lex and use code LEX to get $35 off - BetterHelp: https://betterhelp.com/lex to get 10% off - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera EPISODE LINKS: Peter's website: http://www.math.columbia.edu/~woit/ Peter's blog: https://bit.ly/3xCwm9F Not Even Wrong (book): https://amzn.to/3peDzZs Quantum Theory, Groups, and Representations (book): https://amzn.to/316iAjf Love and Math (book): https://amzn.to/3If7B8m The Second Creation (book): https://amzn.to/3rlWzIu PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:22) - Physics vs mathematics (21:51) - Beauty of mathematics (43:42) - String theory (1:12:15) - Theory of everything (1:32:23) - Twistor theory and spinors (1:48:50) - Nobel Prize likelihood for theory of everything (1:52:36) - Simulating physics (1:56:07) - Sci-Fi, aliens and space (2:05:19) - Responsibility of scientists

3 Dec 20212h 23min