#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Josh Barnett is an MMA fighter, catch wrestler, and a scholar of violence. Please support this podcast by checking out our sponsors: - Munk Pack: https://munkpack.com and use code LEX to get 20% off - LMNT: https://drinkLMNT.com/lex to get free sample pack - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings - Rev: https://rev.ai/lex to get 7-day free trial EPISODE LINKS: Josh's Website: https://www.joshbarnett.com/ Josh's Twitter: https://twitter.com/JoshLBarnett Josh's Instagram: https://www.instagram.com/joshlbarnett Josh's Facebook: https://www.facebook.com/JoshBarnettOfficial Josh's Wikipedia: https://en.wikipedia.org/wiki/Josh_Barnett Josh's YouTube: https://www.youtube.com/channel/UCyZmZwQESO8G0BOSHTpZcvg PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:29) - Nietzsche (13:47) - Good and Evil (28:59) - Joe Rogan library (30:57) - Catch wrestling (41:03) - Anarchy (59:32) - Hitler and Stalin (1:16:34) - Karl Gotch (1:24:59) - Mike Tyson (1:33:20) - Violent victory (1:41:29) - Fedor Emelionenko (1:43:50) - Greatest MMA fighters of all time (1:53:47) - Early UFCs (1:58:32) - Advice for young people (2:02:24) - The value of competition (2:05:02) - Blade Runner (2:15:54) - Meaning of life

1 Mars 20212h 18min

Andrew Huberman is a neuroscientist at Stanford. Please support this podcast by checking out our sponsors: - MasterClass: https://masterclass.com/lex to get 15% off - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Andrew's YouTube: https://www.youtube.com/channel/UC2D2CMWXMOVWx7giW1n3LIg Huberman Lab Podcast: https://hubermanlab.libsyn.com/ Andrew's Instagram: https://www.instagram.com/hubermanlab​ Andrew's Wikipedia: https://en.wikipedia.org/wiki/Andrew_...​ Andrew's Website: http://www.hubermanlab.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:03) - Why do humans need sleep? (13:59) - Temperature (16:48) - Optimal temperature for sleep (21:51) - Sleep anxiety (27:55) - 8 hours of sleep (30:31) - Nap (36:18) - Goggins Challenge (51:41) - Breathing while running (56:30) - Anger (59:46) - Testosterone makes effort feel good (1:05:02) - Fasting (1:13:07) - Keto (1:15:58) - Meat (1:21:38) - Nutrition (1:23:03) - Dreams (1:31:11) - REM sleep (1:37:13) - Psychedelics (1:48:36) - DMT (1:53:11) - Creativity (1:56:45) - Pushing the limits of the human mind (2:01:55) - Neuroplasticity (2:06:31) - Neuroscience and AI (2:11:14) - Eye tracking (2:20:28) - New podcast on neuroscience (2:34:59) - Clubhouse (2:47:08) - Elon Musk

28 Feb 20212h 58min

Eric Weinstein is a mathematical physicist and podcaster. Please support this podcast by checking out our sponsors: - Indeed: https://indeed.com/fridman to get $75 credit - Theragun: https://theragun.com/lex to get 30 day trial - Wine Access: https://wineaccess.com/lex to get 20% off first order - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium EPISODE LINKS: Eric's Twitter: https://twitter.com/EricRWeinstein​ Eric's YouTube: https://www.youtube.com/ericweinsteinphd The Portal podcast: https://podcasts.apple.com/us/podcast/the-portal/id1469999563 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:27) - Aliens and physics (11:12) - Breaking the frame of conversation (12:56) - Time travel across multiple dimensions (19:07) - Is the government in possession of alien spacecraft? (25:31) - Freedom of speech (36:49) - Elon Musk (38:07) - Idealism of every era (41:26) - Non-locality of free speech in the Internet age (47:03) - Glenn Beck (48:57) - Joe Rogan (53:41) - Freedom and fear (55:14) - Jeffrey Epstein (58:53) - Aaron Swartz (1:04:29) - Jeffrey Epstein and Geometric Unity (1:24:04) - Cancel culture (1:26:06) - Alex Jones (1:35:01) - Curtis Yarvin (1:39:40) - Michael Malice (1:42:00) - Intellectual Dark Web (1:48:52) - Innovation (2:02:10) - Economics (2:09:29) - Cryptocurrency (2:15:37) - Geometric Unity paper (2:32:42) - David Goggins challenge (2:34:05) - Father and son

23 Feb 20212h 44min

Jim Keller is a legendary microprocessor engineer, previously at AMD, Apple, Tesla, Intel, and now Tenstorrent. Please support this podcast by checking out our sponsors: - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Brooklinen: https://brooklinen.com and use code LEX to get $25 off + free shipping - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order EPISODE LINKS: Jim's Twitter: https://twitter.com/jimkxa Jim's Wiki: https://en.wikipedia.org/wiki/Jim_Keller_(engineer) Tenstorrent: https://www.tenstorrent.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:02) - Good design is both science and engineering (13:03) - Javascript (17:09) - RISC vs CISC (21:09) - What makes a great processor? (22:38) - Intel vs ARM (24:27) - Steve Jobs and Apple (27:05) - Elon Musk and Steve Jobs (32:50) - Father (36:33) - Perfection (42:48) - Modular design (48:22) - Moore's law (55:20) - Hardware for deep learning (1:02:14) - Making neural networks fast at scale (1:09:51) - Andrej Karpathy and Chris Lattner (1:14:05) - How GPUs work (1:18:12) - Tesla Autopilot, NVIDIA, and Mobileye (1:22:52) - Andrej Karpathy and Software 2.0 (1:29:13) - Tesla Dojo (1:31:49) - Neural networks will understand physics better than humans (1:34:02) - Re-engineering the human brain (1:38:56) - Infinite fun and the Culture Series by Iain Banks (1:40:50) - Neuralink (1:46:13) - Dreams (1:50:06) - Ideas (2:00:19) - Aliens (2:05:16) - Jordan Peterson (2:10:13) - Viruses (2:13:22) - WallStreetBets and Robinhood (2:21:25) - Advice for young people (2:23:15) - Human condition (2:25:43) - Fear is a cage (2:30:34) - Love (2:36:57) - Regrets

18 Feb 20212h 44min

Jason Calacanis is an angel investor, entrepreneur, and co-host of All-In Podcast and This Week in Startups. Please support this podcast by checking out our sponsors: - Brave: https://brave.com/lex - Linode: https://linode.com/lex to get $100 free credit - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Rev: https://rev.ai/lex to get 7-day free trial EPISODE LINKS: Jason's Twitter: https://twitter.com/Jason Jason's Website: https://calacanis.com/ Jason's YouTube: https://www.youtube.com/user/ThisWeekIn Jason's Link Tree: https://linktr.ee/calacanis All-In Podcast: https://linktr.ee/allinpodcast This Week in Startups Podcast: https://thisweekinstartups.com/about/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:52) - WallStreetBets and Robinhood (17:58) - How does the WallStreetBets saga end? (21:09) - Capitalism (26:30) - Ideas vs Execution (27:38) - Learning to learn (33:06) - Risk-aversion (39:07) - Robinhood (47:33) - Parler and AWS (49:59) - Social networks (56:33) - Leadership (1:01:21) - Work-life balance (1:09:44) - Great leaders lead by example (1:17:30) - Advice for startup founders (1:21:57) - Clubhouse (1:22:42) - When will we fully re-open the economy (1:33:20) - Augmented reality (1:36:48) - When should a startup raise money? (1:43:44) - David Goggins (1:45:40) - Disagreement with Chamath Palihapitiya (1:58:52) - Story about Elon Musk's darkest moments (2:07:08) - Friendship

15 Feb 20212h 16min

Brendan Eich is the creator of JavaScript and co-founder of Mozilla and Brave. Please support this podcast by checking out our sponsors: - The Jordan Harbinger Show: https://jordanharbinger.com/lex/ - Sun Basket: https://sunbasket.com/lex and use code LEX to get $35 off - BetterHelp: https://betterhelp.com/lex to get 10% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Brendan's Twitter: https://twitter.com/BrendanEich Brendan's Website: https://brendaneich.com Brave browser: https://brave.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:54) - History of early programming languages (11:47) - Physics needs more experiments and less theory (16:24) - JavaScript origin story (41:17) - JavaScript was created in 10 days (50:57) - Marc Andreessen (54:14) - Internet Explorer (57:58) - Evolution of JavaScript (1:03:44) - JavaScript standardization (1:09:33) - TypeScript (1:12:05) - JavaScript ecosystem (1:15:15) - HTML5 (1:18:47) - Making JavaScript fast (1:27:57) - JavaScript is the most popular language in the world (1:38:23) - Advice for programmers (1:44:20) - Browser wars (1:50:50) - Firefox (2:12:33) - Brave (2:25:33) - Basic Attention Token (2:50:36) - California (2:59:48) - Mortality (3:00:54) - Legacy

12 Feb 20213h 4min

Richard Craib is the founder of Numerai, a crowd-sourced, AI-run stock trading system. Please support this podcast by checking out our sponsors: - Audible: https://audible.com/lex to get $9.95 a month for 6 months - Tryolabs: https://tryolabs.com/lex - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil EPISODE LINKS: Richard's Twitter: https://twitter.com/richardcraib Numerai's Twitter: https://twitter.com/numerai Numerai's Website: https://numer.ai PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:12) - WallStreetBets and GameStop saga (22:25) - Evil shorting and chill shorting (24:31) - Hedge funds (30:04) - Vlad (37:00) - Numerai (1:04:16) - Futre of AI in stock trading (1:09:55) - Numerai data (1:13:37) - Is stock trading gambling or investing? (1:17:32) - What is money? (1:20:49) - Cryptocurrency (1:24:06) - Dogecoin (1:28:36) - Advice for startups (1:44:27) - Book recommendations (1:46:29) - Advice for young people (1:50:30) - Meaning of life

7 Feb 20211h 55min

Zev Weinstein is a young man who thinks deeply about the world. Please support this podcast by checking out our sponsors: - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Grammarly: https://grammarly.com/lex to get 20% off premium - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Zev's YouTube: https://www.youtube.com/c/GenerationZW Zev's Twitter: https://twitter.com/zev__weinstein Zev's Instagram: https://www.instagram.com/zev_weinstein/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:52) - Philosophy becomes dangerous in difficult times (12:15) - The power of radical ideas (17:06) - Changing your mind (21:19) - Fear (22:58) - Labels (28:02) - Thomas Aquinas (32:32) - Nietzsche (37:02) - Nature of truth (39:22) - Jordan Peterson (44:54) - Mediums of communication (53:24) - Free will (57:48) - Simulation (1:02:05) - Transcending the limits of human life (1:05:09) - Elon Musk (1:09:30) - Aliens (1:13:01) - Is math invented or discovered? (1:15:36) - Theory of everything (1:17:30) - Eric Weinstein as a dad (1:33:17) - Music (1:40:32) - Advice for young people (1:42:31) - Mortality (1:46:19) - Meaning of life

5 Feb 20211h 49min