#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: - SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru - Pessimists Archive: https://pessimists.co/ - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 - Introduction 08:05 - Molecular basis for human disease 32:04 - Deadliest diseases 37:47 - Genetic component of diseases 46:38 - Genetic understanding of disease 1:02:25 - Unified theory of human disease 1:08:26 - Genome circuitry 1:33:29 - CRISPR 1:45:06 - Mitochondria 1:53:10 - Future of biology research 2:22:46 - The genetic circuitry of disease

25 Okt 20202h 40min

George Hotz (geohot) is a programmer, hacker, and the founder of Comma.ai. Please support this podcast by checking out our sponsors: - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 40% & free shipping - Decoding Digital: https://appdirect.com/decoding-digital - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Comma.ai's Twitter: https://twitter.com/comma_ai Comma.ai's Website: https://comma.ai/ George's Instagram: https://www.instagram.com/georgehotz George's Twitch: https://www.twitch.tv/georgehotz George's Twitter: https://twitter.com/realgeorgehotz Comma.ai YouTube (unofficial): https://www.youtube.com/channel/UCwgKmJM4ZJQRJ-U5NjvR2dg PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 - Introduction 07:02 - Will human civilization destroy itself? 09:49 - Where are the aliens? 14:36 - Tic Tac UFO and Bob Lazar 17:04 - Conspiracy theories 19:07 - The programming language of life 23:28 - The games that humans play 31:58 - Memory leaks in the simulation 34:29 - Theories of everything 36:14 - Ethereum startup story 44:02 - Cryptocurrency 53:28 - Self-help advice 57:08 - Comma.ai 59:02 - Comma two 1:07:50 - Tesla vs Comma.ai 1:16:53 - Driver monitoring 1:30:34 - Communicating uncertainty 1:32:22 - Tesla Dojo 1:38:50 - Tesla Autopilot big rewrite 1:45:09 - How to install the Comma Two 1:49:44 - Openpilot is Android & Autopilot is iOS 1:58:59 - Waymo 2:10:12 - Autonomous driving and society 2:12:24 - Moving 2:15:29 - Advice to Startups 2:28:32 - Programming setup 2:31:32 - Ideas that changed my life 2:39:37 - GPT-3 2:42:57 - AGI 2:47:00 - Programming languages that everyone should learn 2:53:33 - How to learn anything 2:56:05 - Book recommendations 3:04:28 - Love 3:06:17 - Psychedelics 3:08:38 - Crazy

22 Okt 20203h 13min

Chris Lattner is a world-class software & hardware engineer, leading projects at Apple, Tesla, Google, and SiFive. Please support this podcast by checking out our sponsors: - Blinkist: https://blinkist.com/lex and use code LEX to get a free week of premium - Neuro: https://www.getneuro.com and use code LEX to get 15% off - MasterClass: https://masterclass.com/lex to get 15% off annual sub - Cash App: https://cash.app/ and use code LexPodcast to get $10 EPISODE LINKS: Chris's Twitter: https://twitter.com/clattner_llvm Chris's Website: http://nondot.org/sabre/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 - Introduction 07:12 - Working with Elon Musk, Steve Jobs, Jeff Dean 12:42 - Why do programming languages matter? 18:42 - Python vs Swift 29:35 - Design decisions 34:53 - Types 38:41 - Programming languages are a bicycle for the mind 41:13 - Picking what language to learn 47:12 - Most beautiful feature of a programming language 56:36 - Walrus operator 1:06:03 - LLVM 1:11:15 - MLIR compiler framework 1:15:21 - SiFive semiconductor design 1:27:56 - Moore's Law 1:31:09 - Parallelization 1:35:37 - Swift concurrency manifesto 1:46:26 - Running a neural network fast 1:52:03 - Is the universe a quantum computer? 1:57:44 - Effects of the pandemic on society 2:14:56 - GPT-3 2:19:15 - Software 2.0 2:32:41 - Advice for young people 2:37:24 - Meaning of life

19 Okt 20202h 47min

Scott Aaronson is a quantum computer scientist. Please support this podcast by checking out our sponsors: - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - BetterHelp: https://betterhelp.com/lex and use code LEX to get 10% off EPISODE LINKS: Scott's Blog: https://www.scottaaronson.com/blog/ Our previous episode: https://www.youtube.com/watch?v=uX5t8EivCaM PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 - Introduction 07:46 - Simulation 12:38 - Theories of everything 18:18 - Consciousness 40:32 - Roger Penrose on consciousness 50:44 - Turing test 54:31 - GPT-3 1:03:02 - Universality of computation 1:09:33 - Complexity 1:15:38 - P vs NP 1:27:57 - Complexity of quantum computation 1:40:03 - Pandemic 1:53:49 - Love

12 Okt 20201h 56min

Lisa Feldman Barrett is a neuroscientist, psychologist, and author. Please support this podcast by checking out our sponsors: - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get free vitamin D3/K2 - Magic Spoon: https://magicspoon.com/lex and use code LEX to get free shipping - Cash App: https://cash.app/ and use code LexPodcast to get $10 EPISODE LINKS: Seven and a Half Lessons About the Brain (book): https://amzn.to/2Sp5ar9 How Emotions Are Made (book): https://amzn.to/2GwAFg6 Lisa's Twitter: https://twitter.com/LFeldmanBarrett Lisa's Website: https://lisafeldmanbarrett.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 - Introduction 06:35 - Are we alone in the universe? 08:03 - Life on Earth 12:55 - Collective intelligence of human brains 21:43 - Triune brain 27:52 - The predicting brain 35:48 - How the brain evolved 41:47 - Free will 50:40 - Is anything real? 1:03:13 - Dreams 1:09:00 - Emotions are human-constructed concepts 1:34:29 - Are women more emotional than men? 1:43:05 - Empathy 2:14:46 - Love 2:18:40 - Mortality 2:20:16 - Meaning of life

4 Okt 20202h 24min

Michael Malice is a political thinker, podcaster, and author. Please support this podcast by checking out our sponsors: - SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru - DoorDash: https://doordash.com/ and use code LEX to get $5 off - MasterClass: https://masterclass.com/lex to get 15% off annual sub EPISODE LINKS: Michael's Twitter: https://twitter.com/michaelmalice Michael's Community: https://malice.locals.com/ Michael's YouTube: https://www.youtube.com/channel/UC5tj5QCpJKIl-KIa4Gib5Xw Michael's Website: http://michaelmalice.com/about/ Your Welcome podcast: https://bit.ly/30q8oz1 The New Right (book): https://amzn.to/34gxLo3 Dear Reader (book): https://amzn.to/2HPPlHS PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 - Introduction 04:15 - Sponsors 07:58 - Putin and the Russian soul 15:01 - Love and trolling 25:31 - Problem with government 31:03 - Anarchism 53:07 - Politics 54:59 - Are most people capable of thinking deeply? 1:02:08 - Willy Wonka and Albert Camus view of life 1:08:08 - Trolling 1:12:26 - Conspiracy theories 1:29:43 - Donald Trump and the Election 1:36:58 - Trump Biden presidential debates 1:41:15 - Journalism is broken 1:47:56 - Communism 1:54:02 - Presidential candidates 2:04:34 - Libertarian party 2:14:56 - Objectivism 2:24:17 - Trolling 2:35:21 - The New Right 2:43:29 - Cancel culture 3:13:17 - Book recommendations 3:18:08 - Fear of mortality 3:21:08 - Meaning of life

2 Okt 20203h 24min

Joe Rogan is a comedian, UFC commentator, and the host of the Joe Rogan Experience. Please check out our sponsors to get a discount and to support this podcast: - Neuro: https://www.getneuro.com and use code LEX - Eight Sleep: https://eightsleep.com/lex and use code LEX - Dollar Shave Club: https://dollarshaveclub.com/lex Episode Links: Joe's Instagram: https://www.instagram.com/joerogan Joe's Twitter: http://twitter.com/joerogan JRE (Spotify): https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk JRE (Apple): https://podcasts.apple.com/us/podcast/the-joe-rogan-experience/id360084272 JRE (YouTube): https://www.youtube.com/channel/UCzQUP1qoWDoEbmsQxvdjxgQ If you would like to get more information about this podcast go to https://lexfridman.com/podcast or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon. Here's the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time. OUTLINE: 00:00 - Introduction 05:17 - Fear of mortality 06:48 - Chaos of 2020 and beyond 10:32 - Are we going to be okay? 19:30 - Violence, competition, and Sober October 26:45 - Mike Tyson 27:49 - Managing obsession 30:13 - Jiu jitsu game 35:55 - Best martial art for self defense 39:30 - Guns 43:59 - Memorable JRE moments 49:31 - Ideas breed in brains of humans 56:08 - Advice for Lex 1:06:09 - Long-form conversation 1:12:28 - Meaning of life

26 Sep 20201h 19min

James Gosling is the founder and lead designer of the Java programming language. Please check out our sponsors to get a discount and to support this podcast: - Public Goods: https://publicgoods.com/lex and use code LEX - BetterHelp: https://betterhelp.com/lex - ExpressVPN: https://www.expressvpn.com/lexpod If you would like to get more information about this podcast go to https://lexfridman.com/podcast or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon. Here's the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time. OUTLINE: 0:00 - Introduction 4:45 - Irrational numbers 8:04 - Math and programming 10:36 - Coding style 14:41 - First computer 23:54 - Lisp 27:22 - Write an Emacs implementation in C 35:15 - Early days of the Internet 45:57 - Elon Musk, Steve Jobs, Jeff Bezos 56:13 - Work hard and smart 58:48 - Open source 1:10:25 - Java 1:28:31 - Java virtual machine 1:44:05 - Android 1:47:04 - Advice

24 Sep 20201h 51min