SHOCKING Truth About Thalidomide's Dark Past and Remarkable Comeback! The Bio Brief episode 12

Delve into the historical impact of Thalidomide in Episode 12 of "The Biology Brief" with insightful anecdotes from Dr. Jim Cardelli and Kiley Grant. From its origins in mid-1950s Germany to the devastating consequences leading to its ban in 1961, explore the intended uses and the profound fallout that reshaped the FDA's drug approval regulations. Learn about Francis Kelsey's heroic stance at the FDA, preventing Thalidomide approval in the US and avoiding potential tragedies. Uncover the overlooked clinical trials in the US, the disastrous outcomes, and the profound effects on the FDA's oversight. Understand how this repurposed drug evolved from a notorious history to becoming a crucial player in cancer treatment, showcasing the resilience and self-correcting nature of scientific advancements. Our company: https://www.oleo.live/ Buy Oligen here: https://oleocanthal.co/ 1:17 Jim remembers the impact of thalidomide in 1960.. He is really old. 2:04 Beginnings of Thalidomide in Germany mid 1950's. 3:00 Banned in 1961. Children born with deformities 3:53 Intended uses of Thalidomide 5:51 The fallout from this disaster changed how the FDA regulates drug approvals. 6:10 Francis Kelsey A hero in the FDA Stopped approval of Thalidomide being approved in the US 9:15 The FDA turned a blind eye to clinical trials using Thalidomide in the US which caused deaths and birth defects 10:47 What does Thalidomide do? 16:07 Dr. Kelsey the hero of the FDA as regards Thalidomide and more 20:10 The rebirth of Thalidomide as a drug for other indications. Starting with Leprosy 1965 23:43 Additional indications for Thalidomide including cancers, angiogenesis 26:00 Thalidomide derivatives 30:56 Thalidomide, a repurposed drug 35:00 How does Thalidomide do what it does? AND that thalidomide opened up a whole new area of cancer therapeutics 40:32 Thalidomide from Zero to Hero. Science as a self-correcting process