Episode 5: Tesamorelin vs. Ipamorelin | Peptides for Growth Hormone, Fat Loss, and Better Sleep

Welcome back to Peptides for Women podcast, my little 80s babes!

Today we’re digging into two of the most fascinating (and fun to say!) peptides: Tesamorelin and Ipamorelin.

Both of these peptides help your body make more growth hormone, which naturally declines in your 30s, 40s, and 50s. And since growth hormone is the secret sauce for lean muscle, fat loss, skin, sleep, and recovery, this is a conversation you don’t want to miss.

In this episode, I break down:

• Why tesamorelin is especially powerful for midlife belly fat and body composition
• The “thermostat vs. tap” analogy to help you understand their unique roles
• How ipamorelin supports deep sleep, recovery, and mood—without messing with other hormones
• What the research really says about fat loss, muscle, and brain health
• How these peptides can be used together for even better results
• The importance of healthy foundations (protein, lifting, sleep, sun, steps) before adding peptides

📘 Resources Mentioned:

1. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial

⁠https://pubmed.ncbi.nlm.nih.gov/25038357/⁠

2. Effects of Tesamorelin on Neurocognitive Impairment in Persons With HIV and Abdominal Obesity

⁠https://pubmed.ncbi.nlm.nih.gov/39813152/⁠

3. Tesamorelin Modestly Reduces Liver Fat

⁠https://www.jwatch.org/na35376/2014/08/08/tesamorelin-modestly-reduces-liver-fat⁠

4. Ipamorelin, the first selective growth hormone secretagogue

⁠https://pubmed.ncbi.nlm.nih.gov/9849822/⁠

5. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats

⁠https://pubmed.ncbi.nlm.nih.gov/10828840/⁠

6. The role of peptides in bone healing and regeneration: a systematic review

⁠https://pmc.ncbi.nlm.nih.gov/articles/PMC4940902/⁠

Links & Resources:

• 🔗 Learn more at: ⁠⁠⁠⁠⁠⁠⁠⁠elliemd.com/JenniferWoodwardNutrition⁠⁠⁠⁠⁠⁠⁠⁠
• 🎯 Take my free peptide quiz and get a personalized, midlife-smart roadmap for the peptides that actually match your symptoms and goals: ⁠https://quiz.jenniferwoodwardnutrition.com/peptide-quiz
• 🎓 Enroll in the Peptides for Practitioners Certification Course and get $100 off for podcast subscribers: ⁠⁠⁠⁠⁠https://www.carrotsncake.com/offers/TrVo7mCz?coupon_code=PFPJENNIFER⁠⁠⁠⁠⁠
• 🧬 Want to pair GLP-1s with functional lab testing? ⁠⁠⁠⁠⁠https://learn.jenniferwoodwardnutrition.com/invitation⁠⁠⁠⁠⁠
• 📩 Grab The Body Edit Guide here for full protocols, labs, and more: ⁠⁠⁠⁠⁠https://stan.store/jenniferwoodwardnutrition/p/get-the-body-edit⁠⁠⁠⁠⁠

‼️Disclaimer‼️

This podcast is for informational purposes only and does not provide medical advice. Always speak with your licensed healthcare provider before starting or changing any medication or treatment plan.