Ep 74: Best of ESMO 2025: Part 2 of 2
Melanoma Matters22 Dec 2025

Ep 74: Best of ESMO 2025: Part 2 of 2

Summary

In this Part 2 Best of ESMO 2025 episode of Melanoma Matters, hosts James Larkin and Sapna Patel cover the IO Biotech phase 3 trial, Checkmate 238 final results, the Safe Stop trial, the ECOG-ACRIN STAMP trial for Merkel cell carcinoma, and a promising TCR therapy for uveal melanoma.


Keywords

melanoma, cancer research, immunotherapy, clinical trials, ESMO, IO Biotech, Checkmate 238, Safe Stop trial, STAMP trial, uveal melanoma


Takeaways

The IO Biotech trial missed its primary endpoint for PFS.

Checkmate 238 confirmed previous findings on RFS and DMFS.

The Safe Stop trial suggests early discontinuation of therapy may be safe.

STAMP trial shows potential for adjuvant pembrolizumab in Merkel cell carcinoma.

Uveal melanoma TCR therapy shows promise.

Understanding subgroup analysis in interpreting trial results.

Patient management decisions should consider trial limitations and real-world implications.


Chapters

00:00 Travel Tips and Strategies

04:43 IO Biotech Phase 3 Trial Insights

12:00 Checkmate 238 Discussion

13:10 Navigating Publication Challenges

13:59 Checkmate 238 Results

15:58 Late Relapses and Follow-Up Strategies

17:57 Time of Day of Infusion

20:50 Safe Stop Trial: Evaluating Treatment Duration

33:12 STAMP Trial: Adjuvant Therapy for Merkel Cell Carcinoma

35:05 IMA-203 (Anzu-cel) trial in uveal melanoma


Avsnitt(84)

Ep 81: IGNYTE trial (RP1 + nivo)

Ep 81: IGNYTE trial (RP1 + nivo)

SummaryThe conversation covers the published data from the IGNYTE study - RP1 + nivolumab: response rate and safety profile, RNA-seq analysis, and toxicity. The key takeaways include insights into cli...

13 Feb 32min

Ep 80: 2025 Holiday Special

Ep 80: 2025 Holiday Special

SummaryHappy Holidays and Festive Season Everyone! In this episode of Melanoma Matters, hosts Sapna Patel and James reflect on their "cultural" experiences over the past year, discussing movies, music...

30 Dec 202535min

Ep 79: coBRIM, COMBI-d 5-year follow-up

Ep 79: coBRIM, COMBI-d 5-year follow-up

SummaryIn this episode of Melanoma Matters, James awaits an invitation to a film premiere (The Penguin Lessons) and we all await a picture of him in his tuxedo! Sapna and James go on to discuss the 5-...

29 Dec 202536min

Ep 78 TRAILER: MEK inhibitor trials

Ep 78 TRAILER: MEK inhibitor trials

Enjoy this short trailer on MEK inhibitor monotherapy trials in melanoma

29 Dec 20251min

Ep 78: MEK inhibitor trials (METRIC, NEMO, pimasertib)

Ep 78: MEK inhibitor trials (METRIC, NEMO, pimasertib)

SummarySo many shoutouts in this episode of Melanoma Matters! Sapna and James engage in a lively discussion about MEK inhibitors as monotherapy treatment. They explore the METRIC, NEMO, and pimasertib...

29 Dec 202537min

Ep 77: Guest Merrick Ross

Ep 77: Guest Merrick Ross

SummaryIn this episode of Melanoma Matters, hosts James Larkin and Sapna Patel engage with Merrick Ross, a seasoned surgical oncologist, discussing his background, the evolution of surgical practice w...

29 Dec 202544min

Ep 76: KEYNOTE 054 7-year follow-up

Ep 76: KEYNOTE 054 7-year follow-up

SummaryIn this Episode, hosts James & Sapna go into the 7-year follow-up from the randomized phase 3 adjuvant trial of pembrolizumab versus placebo for stage III melanoma, KEYNOTE-054There's a bit too...

28 Dec 202528min

Ep 75: Immune-mediated Myocarditis

Ep 75: Immune-mediated Myocarditis

SummaryIn this (longest to-date) episode, James and Sapna delve into the not-so-rare occurence of immune-mediated myocarditis, particularly in the context of immune checkpoint inhibitors. The hosts di...

28 Dec 20251h 4min

Populärt inom Hälsa

somna-med-henrik
rss-bara-en-till-om-missbruk-medberoende-2
rss-jossan-nina
inga-beiga-morsor
rss-vuxna-pa-latsas
angestpodden
not-fanny-anymore
rss-viktmedicinpodden
johannes-hansen-podcast
sexnoveller-deluxe
sova-med-dan-horning
sa-in-i-sjalen
rss-sjalsligt-avkladd
sag-det-bara
brottarbroder
till-sangs
rss-angra-inget-3
rss-fet-fakta-podcast
sex-pa-riktigt-med-marika-smith
rss-the-house-podcast-3