February 10, 2026: Amyloidosis in Focus: Diagnosis Delays, Early Treatment, and What Clinicians Must Know | JACC This Week

February 10, 2026: Amyloidosis in Focus: Diagnosis Delays, Early Treatment, and What Clinicians Must Know | JACC This Week

In this episode of JACC This Week, Dr. Harlan M. Krumholz and Dr. Carolyn S.P. Lam discuss a dedicated issue of JACC focused on cardiac amyloidosis—one of the fastest-evolving areas in cardiovascular medicine.
They explore new evidence highlighting significant delays in diagnosing ATTR cardiomyopathy, the early divergence of mortality benefit with timely treatment, and why time to diagnosis is no longer a neutral factor. The conversation also examines secondary analyses from major clinical trials, practical guidance for amyloidosis evaluation and management, and Dr. Krumholz's Editor's Page on "computable diagnosis" as a moral imperative.
This episode places emerging science in clinical context, emphasizing urgency, equity, and how clinicians should be thinking differently about diagnosis, staging, and access to therapy in amyloid heart disease.
Read Full issue here: https://www.jacc.org/toc/jacc/87/5
Keywords: cardiac amyloidosis, amyloid heart disease, ATTR cardiomyopathy, computable diagnosis

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Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

In this special Season 2 wrap-up of JACC This Week, Dr. Harlan Krumholz and Dr. Carolyn Lam reflect on the pilot season, the energy of ACC.26, and what they've learned from listeners along the way. Fr...

7 Apr 4min

March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

This week's edition of JACC This Week brings Dr. Carolyn Lam and Dr. Harlan Krumholz into a deep exploration of a special issue devoted to innovative cardiovascular research emerging from China. As th...

31 Mars 19min

March 24, 2026: Cardiometabolic Health, COVID Impact & Prevention Science | JACC This Week

March 24, 2026: Cardiometabolic Health, COVID Impact & Prevention Science | JACC This Week

Drs. Carolyn Lam and Harlan Krumholz unpack new JACC research on cardiometabolic health, highlighting how COVID‑19 shaped cardiovascular care, mortality patterns, and disparities. They also break down...

24 Mars 13min

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

In this episode, Dr. Carolyn Lam and Dr. Harlan Krumholz break down key studies from this week's JACC issue, including new evidence on Chagas‑related heart failure, updated diastolic function guidelin...

17 Mars 17min

March 10, 2026: Inside JACC Stats: The State of CV Health in Focus | JACC this Week

March 10, 2026: Inside JACC Stats: The State of CV Health in Focus | JACC this Week

Dr. Carolyn Lam and Dr. Harlan Krumholz sit down with Dr. Rishi Wadhera to unpack the first-ever JACC Cardiovascular Statistics issue. They explore why this annual report matters, the key trends in U....

10 Mars 18min

March 3, 2026: Hypertrophic Cardiomyopathy  in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

March 3, 2026: Hypertrophic Cardiomyopathy in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight a mini-focus issue on hypertrophic cardiomyopathy (HCM), a field undergoing rapid transformation. The discussion ce...

3 Mars 18min

February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight the 2025 Adult Congenital Heart Disease (ACHD) Guidelines and explore what they signal for the future of cardiovasc...

24 Feb 13min

JACC This Week Bonus Episode – Women's Cardiovascular Health: From Inclusion to Redesign

JACC This Week Bonus Episode – Women's Cardiovascular Health: From Inclusion to Redesign

This bonus episode continues the conversation from the JACC Women's Cardiovascular Health Issue, moving from science to systems. In this extended discussion, Drs. Carolyn Lam and Harlan Krumholz are j...

17 Feb 14min

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