AnelleO: 3D Printing the Future of Vaginal Drug Delivery

📋 Episode Summary:
In this cutting-edge episode, Dr. Brittany Barreto sits down with Dr. Rahima Benhabbour—chemist, biomedical engineer, and founder of AnelleO, a UNC spinout transforming intravaginal drug delivery. With her roots in Algeria and her scientific training spanning three continents, Dr. Benhabbour brings a global, deeply human perspective to women's health innovation.

Together, they discuss how outdated vaginal ring technology inspired the development of AnelleO PRO, a 3D-printed, customizable progesterone ring designed for women undergoing fertility treatment. Unlike traditional rings that waste over 85% of the active drug, AnelleO's platform maximizes drug release and allows for multi-drug, multi-use configurations—including HIV prevention and contraception in a single product.

This episode is a must-listen for those interested in biotechnology, platform therapeutics, and the engineering breakthroughs reshaping reproductive care.

🧠 What You’ll Learn:

• Why traditional intravaginal rings are inefficient and outdated

• How AnelleO’s 3D printing technology allows for better drug release, fit, and personalization

• The clinical and regulatory milestones leading to first-in-human trials for fertility care

• How multi-purpose prevention technologies could transform global contraception and HIV care

• The growing movement toward non-hormonal contraception and the future of male birth control

💬 Quotable Moment:
"Just because it’s hard doesn’t mean we shouldn’t do it. Someone has to pave the way." – Dr. Rahima Benhabbour

🔗 Resources Mentioned:

• AnelleO: www.anelleo.com

• Dr. Benhabbour’s Lab: benhabbour.web.unc.edu

• Nature Reviews Bioengineering article on AnelleO’s technology

🧪 Episode Sponsor:
This episode is brought to you by:
Withum – A forward-thinking accounting and advisory firm supporting innovators in the Women’s Health and Wellness industry. Learn more at withum.com.

🍼 Nest Collaborative – The pioneers in telehealth lactation support. Book your virtual appointment with an International Board Certified Lactation Consultant at . Same-day visits often available and hundreds of insurance plans accepted, including Medicaid. www.nestcollaborative.com