Can Psychedelics Reset a Depressed Brain?

Can psilocybin treat depression within a day? In this episode, Dr Karan Rajan sits down with psychedelic researcher Dr Rayyan Zafar to break down the science of psilocybin, treatment-resistant depression, brain scans, microdosing, and whether psychedelic therapy could become a real part of mainstream mental health care.
They explore why current antidepressants do not work for everyone, how psychedelics may affect the brain differently, what researchers are seeing on scans after a single dose, and why the conversation around psychedelic therapy is far more nuanced than internet hype suggests.
In this episode:

Why psychiatry needs new tools for depression
Why SSRIs do not work for everyone
How psilocybin interacts with serotonin receptors
The idea of a “plastic window” after psychedelic therapy
Whether psychedelics could help healthy people, not just patients
What the evidence says about microdosing
The real safety questions around psychedelic treatment
DMT, short-acting psychedelics, and where the field may go next

00:00 - Welcome Dr Rayyan Zafar
04:35 - How psychedelics work in the brain
07:29 - Psychedelics, culture and meaning-making
08:21 - What counts as treatment-resistant depression?
15:26 - Could psychedelics become preventative medicine?
17:20 - Depression, rumination and the default mode network
20:37 - The “plastic window” and why therapy matters
26:09 - The truth about Microdosing
33:20 - Safety, screening and who should avoid psychedelics
42:04 - DMT, ayahuasca and future treatments
44:04 - Why short-acting psychedelics matter
About Dr Karan:
Dr. Karan Rajan is a doctor, author, and educator dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

🚽 Discover Throne’s incredible new smart toilet device at http://thronescience.com

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook

📕 Pre-order my new book, This Is Vital Information, here: https://linktr.ee/ThisisVitalInformation?utm_source=linktree_profile_share&ltsid=472cbbde-00e2-42ab-8a3f-725656fab3a5

🔥 Head to https://loamscience.com/ try LOAM - and get an additional 10% with code POD10.

🤖 Discover my digital twin here: http://DrKaran.ai

Connect with me:
Instagram: / drkaranrajan
Facebook: / drkaran
TikTok: / dr.karanr
X: / drkaranrajan
Website: www.drkaranrajan.com
#Psilocybin #MentalHealth #Neuroscience #PsychedelicTherapy #healthpodcast

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(119)

Weight Loss Surgeon: Why Exercise and Calorie Cutting Doesn’t Work | Dr Andrew Jenkinson

Weight gain is not a moral issue, it’s a biological one. Willpower and calorie counting alone won’t help you drop those unwanted pounds - so what does it really take?In this episode I speak to weight ...

20 Juli 40min

Endometriosis Surgeon Explains What Everyone Gets Wrong - Dr Lora Liu

Endometriosis affects 1 in 10 women, yet it still takes years to diagnose. Learn why it's so often missed, what the symptoms really look like, and the latest science on treating this misunderstood dis...

13 Juli 49min

Is Your Back Pain All In Your Head? The Surprising Science of Healing Pain - Dr Anisha Joshi

If you're struggling with back pain, neck pain or unexplained body aches, the answer might not be where it hurts. Learn how your brain, stress, sleep and movement all shape pain.Dr Anisha Joshi is an ...

6 Juli 41min

The Anti-Ageing Fitness Plan Anyone Can Follow | Dan Go

💬 If you want to live longer, stay independent and have more energy, you don't need another fitness hack - you need to move more. ⚡️ Walking, building strong legs, improving grip strength and simply ...

29 Juni 54min

How To Eat Your Way To Better Skin | Dr Thivi Maruthappu

💬 Skin conditions affect a massive proportion of the population. Most people reach for creams and retinoids first - but the solution is often much simpler. So what should you do to protect your skin ...

22 Juni 44min

Strengthen Your Feet And You’ll Live Longer - Fix Posture, Back Pain and Bunions

💬 If you improve your foot health and strength, you’ll not only fix back pain and bunions - you’ll increase your lifespan and improve your brain health!⚡Most of us ignore our feet, squishing them int...

15 Juni 42min

Should You Really Be Taking Peptides? | AMA with Dr Karan

💬 Should you be taking peptides? From anti-aging promises to superhuman healing - peptides are massively hyped right now, and are being aggressively marketed online. But here’s why you should think t...

8 Juni 26min

The Prostate Cancer Warning Signs Men Should Know

Prostate cancer is the most common cancer in men, but it often has no obvious symptoms.In this episode, Dr Karan Rajan speaks with Professor Prabhakar Rajan, a urologist and prostate cancer specialist...

1 Juni 41min