Founder vs. Cancer: A Real-Life Hail Mary

Founder vs. Cancer: A Real-Life Hail Mary

After watching Project Hail Mary, Cal sees more than a sci-fi story about saving the stars—he sees a blueprint for how humans might survive the age of AI. That insight leads him to a real-life story even more extraordinary. When tech founder Sid Sijbrandij is diagnosed with a rare, aggressive cancer, the traditional medical system eventually runs out of answers. Most people would accept that outcome. Sid does the opposite. He treats his own disease like an open- source problem—gathering data, building a team, and chasing solutions across the globe with the same mindset that helped build GitLab into a billion-dollar company. With the help of AI, Cal translates this complex scientific journey into a human story anyone can follow. One that's filled with pancakes, partnerships, love, and a radical idea: What if the future of survival—against disease, against uncertainty, against AI itself—belongs to those who adapt fastest? This episode is about more than cancer. It's about how humans fight back.

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Avsnitt(446)

Welcome To Authentic AI

Welcome To Authentic AI

For the first time, you can ask Cal what you want to know about asking better questions. About your next podcast. A business move. A personal situation. Cal will get back to you personally with the he...

7 Juli 1h 16min

You Are Stronger Than Steel

You Are Stronger Than Steel

The change in front of all of us right now may be the most radical humans have ever faced. Who do you want guiding you through it? Courtney Harrison would be an intriguing choice. She's a rare breed o...

30 Juni 53min

The AI Teaching Template

The AI Teaching Template

Every teacher struggling with AI use in the classroom needs to hear this episode. Jamie Metzl has a Ph.D. from Oxford, a law degree from Harvard, and has run 60 marathons. He spent nine years writing ...

23 Juni 33min

Learn Faster. Remember More. (Part 2)

Learn Faster. Remember More. (Part 2)

Cal resumes his conversation with Dr. David Bach, the Harvard-trained neuroscientist who is about to give you an opportunity to upgrade your brain. Dr. Bach is the founder of Optios. His company's wor...

16 Juni 39min

Your Job Just Got Bigger. So Did You.

Your Job Just Got Bigger. So Did You.

Charles Gaudet has coached thousands of CEOs over the years. Yahoo Finance has called him "The CEO Whisperer." In this episode, Cal asks him to turn what he's learned toward a big question: What can e...

9 Juni 58min

YOUR BRAIN. YOUR GUT. YOUR EDGE.

YOUR BRAIN. YOUR GUT. YOUR EDGE.

Graduation stages across America erupted in boos this spring when AI came up. That anxiety isn't just for new grads. It's felt by anyone wondering whether they still have a place in a world being resh...

2 Juni 49min

Big Questions: The Future Of Work

Big Questions: The Future Of Work

In an age when AI has everyone asking what's next for humans, Cal goes looking for answers. He finds them in some unexpected places. A five-year-old girl who walked through a Transylvanian forest to s...

25 Maj 53min

Where Grief Meets Promise

Where Grief Meets Promise

Cal opens this deeply personal episode of Big Questions with a flood of remarkable medical breakthroughs. 3D-printed windpipes. A pancreatic cancer drug that doubles survival rates. Nanotechnology cle...

18 Maj 7min

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