Resolving the dispute over the speed of the expanding universe, and seeking new drug targets for cognitive dysfunction

Resolving the dispute over the speed of the expanding universe, and seeking new drug targets for cognitive dysfunction

First up on the podcast, a new path to calculating the Hubble constant. This value for the universe’s speed of expansion is typically determined in one of two ways, one favored by cosmologists, the other by astronomers. But the resulting values from these methods are consistently different. Staff Writer Daniel Clery joins host Sarah Crespi to discuss how reappearing bursts from deep space, lensed by gravity, could resolve the dispute over the speed of the expanding universe. Next on the show, freelance producer Elah Feder talks with Mauro Costa-Mattioli, principal investigator at Altos Labs’ Institutes of Science, about tuning the “integrated stress response” (ISR) in mouse brains. The ISR pathway turns off much of protein synthesis in cells as a response to stressors such as viral infections or oxygen deprivation. The ISR is overactive in some models of cognitive dysfunction—suggesting the downregulated protein synthesis may hamper brain functions such as memory formation. In his paper, Costa-Mattioli and colleagues show turning on the ISR pathway causes memory problems in mice and turning off the ISR can restore function in mouse models of Alzheimer’s disease and Down syndrome. Although this research was in mice, it suggests cognitive dysfunction associated with many different disorders may involve the ISR—making it a good therapeutic target. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

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A team effort to save a giant fish, the power of moonlight, and how scientists can navigate a tough political environment

A team effort to save a giant fish, the power of moonlight, and how scientists can navigate a tough political environment

First up on the podcast, along Brazil’s Juruá River, local residents have been working with scientists to manage a giant fish called the arapaima—affecting the land, the people, and the economy. Contr...

7 Maj 53min

Watching a spiders’ heart beat, epigenetic ethics, and what science biographies reveal about fame

Watching a spiders’ heart beat, epigenetic ethics, and what science biographies reveal about fame

First up on the podcast, Online News Editor David Grimm shares a batch of fun stories with podcast host Sarah Crespi—from spider hearts racing when traffic gets loud to a disease-preventing house. Sta...

30 Apr 46min

Cleaning up uranium mining, and how the heart avoids cancer

Cleaning up uranium mining, and how the heart avoids cancer

First up on the podcast, freelance science and environmental journalist Quentin Septer joins host Sarah Crespi to talk about a controversial uranium mine getting fast-tracked in South Dakota. Septer c...

23 Apr 30min

The normals | Episode 3

The normals | Episode 3

The final of a three-part limited Science Podcast series that looks at the history of normal human subjects in research In episode two, we heard what happened to the normals program after church volu...

21 Apr 33min

How to keep quantum computers cool, whether prediction markets harm public health, and podcasting on podcasting

How to keep quantum computers cool, whether prediction markets harm public health, and podcasting on podcasting

First up on the podcast, quantum computers require extremely low temperatures—less than 1°C away from absolute zero. But getting down to those temperatures has usually required dilution fridges using ...

16 Apr 50min

The Normals | Episode 2

The Normals | Episode 2

Last time on The Normals, we learned that in the 1950s, the National Institutes of Health (NIH) wanted to recruit many healthy volunteers for basic research. Two peace churches, the Mennonites and the...

14 Apr 27min

A chimpanzee ‘civil war,’ and NASA plans for nuclear propulsion

A chimpanzee ‘civil war,’ and NASA plans for nuclear propulsion

First up on the podcast, freelance science journalist Hannah Richter joins host Sarah Crespi to discuss NASA’s plans to send a nuclear-powered spacecraft to Mars in less than 3 years. Having not launc...

9 Apr 42min

The Normals | Episode 1

The Normals | Episode 1

How do we know what's normal in a person? In the early 1950s, the National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start studying normal humans on a grand scale....

7 Apr 23min

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