Hippocampal Place Cell Sequences Are Impaired in aRat Model of Fragile X Syndrome
The Journal Club18 Apr 2025

Hippocampal Place Cell Sequences Are Impaired in aRat Model of Fragile X Syndrome

Journal of Neuroscience April 9, 2025

Fragile X syndrome (FXS) is a neurodevelopmental disorder that can cause impaired memory and atypical spatial behaviorssuch as “elopement” (i.e., wandering off and becoming lost). Activity in the CA1 subregion of the hippocampus supportsspatial memory and spatial cognition, making it an important candidate to study in the context of FXS; however, how neu-ronal population activity in CA1 is affected by FXS is poorly understood. In this study, we found that the coordination ofpopulations of CA1 neurons during active behavior and waking rest was impaired in a rat model of FXS. These results revealhippocampal physiological deficits that may contribute to cognitive impairments in FXS.

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