Behavioral Modulation and Molecular Definition of Wide-Field Vertical Cells in the Mouse Superior Colliculus
The Journal Club18 Apr 2025

Behavioral Modulation and Molecular Definition of Wide-Field Vertical Cells in the Mouse Superior Colliculus

Journal of Neuroscience April 16, 2025

Understanding how neuronal response preferences emerge remains a fundamental goal in neuroscience. Our ability to target

neuron subpopulations and their embedding in circuits has greatly evolved over the last decades with the development of new

tools including transgenic mouse lines and RNA sequencing methods. Here, we focus on wide-field vertical cells (WFV) which

are found in the superior colliculus, a visual center in the midbrain that is highly conserved across species. Our findings

challenge earlier definitions of this cell type and reconcile them with more modern approaches. Due to their conservation

and connectivity, WFV present a model of choice to investigate how neurons gain their response specificity and relationships

between structure, function, implication in behavior, and molecular profiles.

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