A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat
The Journal Club18 Apr 2025

A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat

Journal of Neuroscience April 16, 2025

“Fear” is widely viewed as a phasic response to certain-and-imminent danger, whereas “anxiety” is a sustained response to

uncertain-or-distal harm. Past work has begun to reveal the neural systems recruited by certain and uncertain anticipated threats

but has yet to rigorously plumb the moment-by-moment dynamics anticipated by theory. Here we used a novel combination of

neuroimaging techniques to demonstrate that certain and uncertain threat recruit a common threat-anticipation circuit. Activity

in this circuit and covert measures of distress showed similar patterns of context-dependent dynamics, exhibiting persistent increases when anticipating uncertain-threat encounters and transient surges just before certain encounters. These observations provide fresh insights into the neurobiology of fear and anxiety, laying the groundwork for more ambitious clinical and mechanistic research.

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