CART Neurons in the Hypothalamic Ventral Premammillary Nucleus (PMv) in Rats Mediate Maternal, But Not Inter-male Aggression
The Journal Club28 Apr 2025

CART Neurons in the Hypothalamic Ventral Premammillary Nucleus (PMv) in Rats Mediate Maternal, But Not Inter-male Aggression

Basu S, Waghade A, Parveen R, Kushwaha A, Mitra S, Kokare DM, Singru PS. CART neurons in the hypothalamic ventral premammillary nucleus (PMv) in rats mediate maternal, but not inter-male aggression. J Neurosci. 2025 Mar 14



This study shows that maternal aggression in rats is driven by activation of CART-expressing neurons in the ventral premammillary nucleus (vPMv), which signal to the ventrolateral ventromedial hypothalamus (VMHvl), while inter-male aggression involves the lateral PMv (lPMv) without CART dependence. CART is identified as a critical mediator specifically for maternal aggression through the PMv–VMHvl pathway.


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