#17 PEM: measuring the threshold and understanding the cause with Dr. Rob Wüst

#17 PEM: measuring the threshold and understanding the cause with Dr. Rob Wüst

What is the threshold over which PEM is induced in chronic illness? This is a hugely important question for sufferers, and one for which Rob Wüst is trying to find an answer.

Assistant Professor in Musculoskeletal Health and Physiology at the Vrije Universiteit Amsterdam, Dr. Rob Wüst is able to see the physiological impact of Long Covid and ME/CFS in skeletal muscle abnormalities.

In his latest study (currently in preprint) he finds that “Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest”, and the abnormalities that he observes in the muscles of this cohort of patients correlate with the Post-Exertional Malaise (PEM), autonomic dysfunction and wearable data that he gathered in another recent study.

In this week’s episode Wüst explains to Emily Kate Stephens how he observed exercise-induced worsening of symptoms in almost half of Long Covid patients when they exceeded their ‘ventilatory threshold’ but the much of the time this is from everyday activities such as hanging the laundry or carrying the groceries. But they discus

He discusses the physiological clues emerging from exercise testing and muscle biopsies in patients when viewed alongside wearable data and expounds on the circulating theories on this, including mitochondrial dysfunction, local hypoxia, and ion channel abnormalities. And he explores the parallels and distinctions between Long Covid and ME/CFS and why interdisciplinary collaboration is vital to unlock these complex, multi-systemic diseases.

The Impact of Bedrest Study 2024

Skeletal muscle adaptations and PEM in LC 2024

Should we be careful with exercise in PEM in LC? 2025

Make Visible

@visible_health

@visible.health

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(41)

#40 Symptom connections in ME/CFS, Long Covid, EDS & Fibromyalgia - Orthostatic Intolerance, pain, PEM & MCAS

#40 Symptom connections in ME/CFS, Long Covid, EDS & Fibromyalgia - Orthostatic Intolerance, pain, PEM & MCAS

REVIEW: with Nancy Klimas, Peter Rowe, Lucinda Bateman, Todd Davenport & Theoharis Theoharides For decades, people living with ME/CFS, Long Covid, fibromyalgia, EDS and other complex chronic illnesses...

7 Aug 1h 4min

#39 ME/CFS & EDS bedbound for 8 years - Learning to Live Again with Lizzie and Amy Mooney

#39 ME/CFS & EDS bedbound for 8 years - Learning to Live Again with Lizzie and Amy Mooney

STORIES: ME/CFS and EDS left Lizzie bedbound for eight years - a mother's fight for answers and a daughter's fight to reclaim independence. Lizzie Mooney became chronically sick with ME/CFS and Ehlers...

24 Juli 52min

#38 Pacing is Power - POTS, PEM, EDS & MCAS strategies with Dr Clayton Powers

#38 Pacing is Power - POTS, PEM, EDS & MCAS strategies with Dr Clayton Powers

STRATEGIES: Physical therapy tools to reduce crashes and improve quality of life for POTS, Post-Exertional Malaise (PEM), EDS, MCAS, and infection-associated chronic conditions such as ME/CFS and Long...

10 Juli 59min

#37 ME/CFS breakthroughs: are treatments getting closer? With Action For ME, NIH, CODA, Bateman Horne Center &

#37 ME/CFS breakthroughs: are treatments getting closer? With Action For ME, NIH, CODA, Bateman Horne Center &

SCIENCE: Are ME/CFS research breakthroughs finally helping us understand the disease and move closer to treatments? ME/CFS has been underfunded and under-researched for decades.  Despite the scale and...

26 Juni 59min

#36 My daughter’s Long Covid changed how I practice medicine with Dr Binita Kane

#36 My daughter’s Long Covid changed how I practice medicine with Dr Binita Kane

STORIES: What do you do when your medical training has no answers for your own child? This is the question that Dr Binita Kane found herself facing in the aftermath of the Covid-19 pandemic. As a Cons...

13 Juni 58min

#35 Vagus nerve stimulation for chronic illness and better health with Dr Elisabetta Burchi

#35 Vagus nerve stimulation for chronic illness and better health with Dr Elisabetta Burchi

SCIENCE: What if a small, non-invasive device could help regulate your nervous system, reduce inflammation, improve cognitive function, and support recovery from chronic illness? Dr Elisabetta Burchi,...

29 Maj 1h 1min

#34 Fibromyalgia and chronic pain management with Ryan Bourdo, Physical Therapist

#34 Fibromyalgia and chronic pain management with Ryan Bourdo, Physical Therapist

STRATEGIES: Physical rehabilitation for chronic pain conditions. If you live with fibromyalgia, ME/CFS, EDS or chronic pain, you've likely heard that exercise may help. You've also probably learned, t...

15 Maj 55min

#33 Hypermobile Ehlers-Danlos Syndrome (hEDS) undiagnosed for 23 years with Dr Lucy Foulkes

#33 Hypermobile Ehlers-Danlos Syndrome (hEDS) undiagnosed for 23 years with Dr Lucy Foulkes

STORIES: Undiagnosed Hypermobile Ehlers-Danlos Syndrome (hEDS) | Chronic Pain, Diagnosis & Living with Complex Chronic Illness For 23 years, Dr Lucy Foulkes has lived with chronic pain, migraines, end...

1 Maj 1h 13min

Populärt inom Hälsa

somna-med-henrik
rss-jossan-nina
rss-bara-en-till-om-beroende-medberoende
bullfika
inga-beiga-morsor
rss-vuxna-pa-latsas
sexnoveller-deluxe
angestpodden
rss-viktmedicinpodden
johannes-hansen-podcast
not-fanny-anymore
rss-hos-psykologen
sa-in-i-sjalen
sova-med-dan-horning
rss-basta-livet
tyngre-traningssnack
halsoveckan-by-tyngre
rss-traningsklubben
medicinvetarna
prestera-mera-by-umara