Peptide of the Week: NAD+ & Tesofensine: Anti-Aging and Brain-Based Weight Loss Explained

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! JD Denham and William T. Haas break down two powerhouse compounds NAD+ and Tesofensine covering what they are, how they work, real-world experience, and how to dose them right.

Chapters:

00:00 – Intro & Life Updates
05:30 – Parenting, Discipline & Boys
10:00 – Family, Values & Growth
18:30 – NAD Explained (What It Does)
25:30 – NAD Benefits & Real Results
29:00 – NAD Dosing & Side Effects
37:45 – NAD Cycles & Best Use
38:15 – Tesofensine Breakdown
42:00 – Energy, Focus & Fat Loss Effects
48:30 – Who Should (and Shouldn’t) Use It
52:30 – Dosing, Side Effects & Warnings
55:30 – School Platform & What’s Next
57:45 – Outro

🧬 What is NAD+? A coenzyme found in every cell in your body — essential for life. Powers over 500 enzymatic reactions and is critical for ATP (cellular energy) production. Declines dramatically with age: 100% at birth → 55% by age 40 → 34% by age 60. That decline is why we age — cells stop repairing and regenerating as well.

🔥 What NAD+ actually does – DNA and cellular repair — slows aging at the genetic level – Boosts natural cellular energy (not stimulant energy) – Neuroprotective — mental clarity, sharper focus, better brain function – Improves insulin sensitivity, lipid regulation, and cardiovascular function – Regulates inflammatory pathways and immune response

🧠 What is Tesofensine? A triple reuptake inhibitor (serotonin + dopamine + norepinephrine). Originally developed for Alzheimer's and Parkinson's — researchers noticed patients losing massive amounts of weight. Clinical trials showed 9–11% average body weight loss over 24 weeks.

⚖️ How Tesofensine works – Targets the brain — makes food stop giving you a dopamine hit – Reduces cravings for sweets and junk without fully suppressing hunger like GLP-1s – Does NOT spike blood sugar during fasting – Real energy increase — dopamine-driven motivation, not jittery stimulant energy – Great GLP-1 transition compound for weaning off without falling off track

💡 Real-world experience JD's first run felt off and tired — gave it a bad rep initially. Second run (last 3 weeks): loves the focused, clean energy, similar to Modafinil. Will: no more naps, more motivated, doesn't want to miss the day. Both agree — take it in the first half of the day, it will keep you up.

⚠️ What to avoid – Do NOT combine with SSRIs, SNRIs, or NDRIs (Zoloft, Wellbutrin, etc.) – Reduce caffeine — unnecessary stimulant overload – Do NOT combine with Modafinil – Not recommended for uncontrolled hypertension, bipolar disorder, or severe anxiety – Monitor blood pressure and run regular bloodwork

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