Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)

Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)

Hosted by Lester Nare and Krishna Choudhary, this episode has two main stories: an astrophysics update on a candidate “dark galaxy” in the Perseus Cluster (a halo that’s ~99.9% dark matter), and a major Alzheimer’s mechanism paper tracing how exercise protects the brain by repairing the blood–brain barrier—with an actionable drug-like path already emerging.


Summary


Candidate dark galaxy — Hubble + Euclid stacking and globular clusters reveal an ultra-faint halo that could test missing satellites and the cusp–core problem (and even “fuzzy dark matter”).

Exercise → Alzheimer’s mechanism — UCSF links a liver enzyme (GPLD1) to BBB repair via TNAP regulation, plus an oral TNAP inhibitor (SBI-425) that mimics the effect in mice.

Rundown — Rubin Observatory’s real-time alert engine, AI-accelerated magnet discovery, a climate-corrected Easter Island history, and the Boba-Kiki effect in baby chicks.


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Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)

Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)

Hosted by Lester Nare and Krishna Choudhary, this episode is a Winter Olympics deep dive from first principles—physics, neuroscience, and climate science in one ride.• Why ice is slippery: the “water ...

18 Feb 1h 50min

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Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)

Hosted by Lester Nare and Krishna Choudhary, this episode jumps from plant biochemistry to quantum metrology to cancer evolution. We start with a University of York breakthrough that solves a ~50-year...

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Hosted by Lester Nare and Krishna Choudhary, this episode is a full-spectrum moonshot: why Artemis II matters, how the mission actually works (SLS, Orion, translunar injection, free-return trajectorie...

4 Feb 1h 9min

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JWST’s “Little Red Dots,” TimeVaults, and the Dawn of Math (EP. 23)

Hosted by Lester Nare and Krishna Choudhary, this episode runs from JWST’s “Little Red Dots” (and what they imply about early supermassive black holes), to a TimeVault method for recording gene expres...

27 Jan 1h 40min

Cloud9 Dark Matter Halo, Jellyfish Sleep, and String Theory Hidden in Nature (EP. 22)

Cloud9 Dark Matter Halo, Jellyfish Sleep, and String Theory Hidden in Nature (EP. 22)

Hosted by Lester Nare and Krishna Choudhary, this episode runs from the deep math of string theory to the biology of sleep—then out to a starless “ghost cloud” that may be a naked dark-matter halo. We...

20 Jan 1h 39min

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Hosted by Lester Nare and Krishna Choudhary, this episode jumps from ancient engineering to modern AI and markets. We start with the newly uncovered Pompeii worksite that finally shows how Romans mixe...

12 Jan 1h 58min

The Physics Behind Fusion’s Biggest Problem (Season Finale) (EP. 20)

The Physics Behind Fusion’s Biggest Problem (Season Finale) (EP. 20)

Hosted by Lester Nare and Krishna Choudhary, this Season Finale closes out Season 1 with a deep dive into the physics behind fusion’s biggest bottleneck: fast magnetic reconnection. We unpack why clas...

23 Dec 20251h 17min

The Race to the Double Helix — Watson, Crick, Franklin & the Real Story of DNA (EP. 19)

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Hosted by Lester Nare and Krishna Choudhary, this single-story deep dive tells the full story of how humanity uncovered the structure of DNA — and the human tensions that shaped it. From Mendel’s pea-...

4 Dec 20251h 34min

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