How the 2025 Nobel Prize on T‑Regs Could Transform Diabetic Foot Care

How the 2025 Nobel Prize on T‑Regs Could Transform Diabetic Foot Care

Dr. Gabrielle Hutchison Donaldson dives into the 2025 Nobel Prize in Physiology or Medicine for discoveries about regulatory T cells (T‑regs), explaining why these immune brakes matter and how they control self‑tolerance.

The episode links T‑reg biology to diabetes and diabetic foot ulcers, covering mechanisms, early T‑reg therapies, and how boosting regulatory pathways could reduce chronic inflammation and improve wound healing.

Practical takeaways include maintaining tight glycemic control, following standard wound care, considering clinical trials, and watching for future localized or engineered T‑reg strategies that might speed healing and prevent amputations.

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Avsnitt(322)

LIMBWatch Series: Riley Csernica, VP of Product Development at DARCO International: From Napkin to Norm: GO Line ™ Unveiled & The DARCO Story Behind Modern Offloading

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The Wound That Hated Debridement: Recognizing Pathergy and Great mimics of Diabetic Foot Infection

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From seizures to Granulation Nation: The Unexpected Story of Phenytoin in Wound Healing

This episode traces how phenytoin — an anticonvulsant known for causing gingival overgrowth — was repurposed into a topical therapy for chronic wounds. It outlines the drug’s mechanisms in wounds: act...

13 Juni 24min

Forgotten Infection Friday- Buruli Ulcer vs Diabetic Foot: Lessons from a Painless Wound

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This episode explores the rare Buruli (Buruli) ulcer caused by Mycobacterium ulcerans and its toxin mycolactone, which destroys tissue, suppresses immune signaling, and reduces pain, leading to delaye...

12 Juni 25min

Why we use Saline vs. Sterile Water vs. Tap Water vs Seawater- Not all water is equal

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In this episode Dr. G explains why 0.9% sterile saline is the preferred when using to cleanse for diabetic foot ulcers, diving into osmosis, isotonicity, and how saline preserves cell function while...

11 Juni 29min

Wound Intelligence Wednesday: Atraumatic Dressings for Diabetic Limbs

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This episode explains traumatic dressing selection for diabetic wounds, emphasizing atraumatic (especially silicone-based) dressings that protect fragile peri-wound skin, preserve keratinocytes and ca...

10 Juni 27min

Beyond Closure/ Post Healing Maintenance : Inside the Long Remodeling Phase of Wound Healing

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Dr. G explains why skin closure in diabetic foot ulcers is a transition, not a cure: the remodeling phase can last months to years, leaving the scar biologically weaker and at high risk of recurrence....

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