System Sundays: NO GUTS, NO GLORY: Microbiome, Diabetes, and Wound Healing

System Sundays: NO GUTS, NO GLORY: Microbiome, Diabetes, and Wound Healing

This episode explains how the gut microbiome — an internal ecosystem of bacteria, fungi, and viruses — regulates inflammation, immunity, metabolism, and wound healing, and how diabetes disrupts that balance.

High blood sugar, altered gut conditions, and repeated antibiotics can cause dysbiosis and leaky gut, driving chronic systemic inflammation, immune dysfunction, biofilm formation, impaired angiogenesis and collagen synthesis, and stalled diabetic wound healing.

Practical approaches discussed include glycemic control, nutrition (fiber and fermented foods), targeted probiotics/prebiotics, exercise, sleep and stress management, antibiotic stewardship, and multidisciplinary care to support both the gut and the wound for better limb salvage outcomes.

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Avsnitt(365)

SMAPs: Rethinking Antimicrobials for Diabetic Foot Care

SMAPs: Rethinking Antimicrobials for Diabetic Foot Care

This episode explores SMAPs — synthetic mimics of antimicrobial peptides — and how they use membrane-targeting chemistry to kill bacteria differently from conventional antibiotics. It covers the scien...

19 Aug 21min

LIMBWatch Series: Dr. Shilpa Rajan Mulki- Look at Your Feet Before You Sleep: Saving Limbs in Resource-Limited Settings

LIMBWatch Series: Dr. Shilpa Rajan Mulki- Look at Your Feet Before You Sleep: Saving Limbs in Resource-Limited Settings

🎙️ Diabetic Foot Files: Limb Watch with Dr. Shilpa Rajan Mulki What if some amputations could be prevented simply by recognizing the warning signs sooner? In this episode of Diabetic Foot Files: Limb...

17 Aug 48min

The Toe That Killed Jack Daniel: The Untold Medical Story

The Toe That Killed Jack Daniel: The Untold Medical Story

A man who built a global whiskey empire may have been felled not by drink or duel but by a small foot injury that turned infected. This episode examines the legend of Jack Daniel’s toe, the historical...

16 Aug 36min

Understanding Undermining- Unseen, unexpected and unforgiving : The Truth Behind “Doctor Made My Wound Bigger” — Understanding Undermining

Understanding Undermining- Unseen, unexpected and unforgiving : The Truth Behind “Doctor Made My Wound Bigger” — Understanding Undermining

This episode explains undermining in diabetic foot ulcers—how tissue destruction can extend beneath intact skin, why wounds may appear larger after debridement, and what that means for healing. We cov...

15 Aug 19min

Teeth in the Tide- When the Ocean Bites: Barracuda Strike and Diabetic Foot Danger

Teeth in the Tide- When the Ocean Bites: Barracuda Strike and Diabetic Foot Danger

In this episode Dr. G recounts a surprising barracuda bite that exposes the challenges of marine injuries, especially for people with diabetes. The episode explains how sharp lacerations, contaminatio...

15 Aug 22min

Forgotten Infection Friday- Madura Foot: The Silent, Years-Long Infection Hiding in Plain Sight

Forgotten Infection Friday- Madura Foot: The Silent, Years-Long Infection Hiding in Plain Sight

This episode reviews Madura foot (mycetoma), a chronic implantation infection characterized by long-standing swelling, multiple sinus tracts, and visible ‘‘grains.’p> There are two main types — eumyce...

15 Aug 33min

LIMBWatch Series: Dr. Andrew JM Boulton, MD, DSc (Hon), FACP, FICP, FRCP-The Man Who Changed Diabetic Foot Care Dr. Andrew Boulton on Neuropathy, Prevention & Saving Limbs Worldwide

LIMBWatch Series: Dr. Andrew JM Boulton, MD, DSc (Hon), FACP, FICP, FRCP-The Man Who Changed Diabetic Foot Care Dr. Andrew Boulton on Neuropathy, Prevention & Saving Limbs Worldwide

Welcome to LIMBWatch — the global movement dedicated to protecting limbs, preventing amputations, and transforming the future of diabetic foot care. In this landmark episode, we welcome one of the wor...

10 Aug 46min

Antimicrobial ≠ Antibiotic: Antimicrobial Doesn’t Mean Antibiotic

Antimicrobial ≠ Antibiotic: Antimicrobial Doesn’t Mean Antibiotic

This episode clarifies the difference between antimicrobials (agents that act against a range of microorganisms) and antibiotics (drugs that specifically target bacteria), and explains related terms l...

9 Aug 22min

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