234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


Avsnitt(418)

169 | C. Thi Nguyen on Games, Art, Values, and Agency

169 | C. Thi Nguyen on Games, Art, Values, and Agency

Games are everywhere, but why exactly do we play them? It seems counterintuitive, to artificially invent goals and obstacles just so we can struggle to achieve them. (And in some games, like Twister, ...

18 Okt 20211h 24min

AMA | October 2021

AMA | October 2021

Welcome to the October 2021 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of que...

14 Okt 20212h 59min

168 | Anil Seth on Emergence, Information, and Consciousness

168 | Anil Seth on Emergence, Information, and Consciousness

Those of us who think that that the laws of physics underlying everyday life are completely known tend to also think that consciousness is an emergent phenomenon that must be compatible with those law...

11 Okt 20211h 25min

167 | Chiara Marletto on Constructor Theory, Physics, and Possibility

167 | Chiara Marletto on Constructor Theory, Physics, and Possibility

Traditional physics works within the "Laplacian paradigm": you give me the state of the universe (or some closed system), some equations of motion, then I use those equations to evolve the system thro...

4 Okt 20211h 35min

166 | Betül Kaçar on Paleogenomics and Ancient Life

166 | Betül Kaçar on Paleogenomics and Ancient Life

In the question to understand the biology of life, we are (so far) limited to what happened here on Earth. That includes the diversity of biological organisms today, but also its entire past history. ...

27 Sep 20211h 14min

165 | Kathryn Paige Harden on Genetics, Luck, and Fairness

165 | Kathryn Paige Harden on Genetics, Luck, and Fairness

It's pretty clear that our genes affect, though they don't completely determine, who we grow up to be; children's physical and mental characteristics are not completely unrelated to those of their par...

20 Sep 20211h 25min

AMA | September 2021

AMA | September 2021

Welcome to the September 2021 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of q...

16 Sep 20213h 38min

164 | Herbert Gintis on Game Theory, Evolution, and Social Rationality

164 | Herbert Gintis on Game Theory, Evolution, and Social Rationality

How human beings behave is, for fairly evident reasons, a topic of intense interest to human beings. And yet, not only is there much we don't understand about human behavior, different academic discip...

13 Sep 20211h 29min

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