234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


Avsnitt(417)

149 | Lee Smolin on Time, Philosophy, and the Nature of Reality

149 | Lee Smolin on Time, Philosophy, and the Nature of Reality

The challenge to a theoretical physicist pushing beyond our best current theories is that there are too many ways to go. What parts of the existing paradigm do you keep, which do you discard, and why ...

31 Maj 20211h 29min

148 | Henry Farrell on Democracy as a Problem-Solving Mechanism

148 | Henry Farrell on Democracy as a Problem-Solving Mechanism

Democracy posits the radical idea that political power and legitimacy should ultimately be found in all of the people, rather than a small group of experts or for that matter arbitrarily-chosen heredi...

24 Maj 20211h 26min

147 | Rachel Laudan on Cuisine, Culture, and Empire

147 | Rachel Laudan on Cuisine, Culture, and Empire

For as much as people talk about food, a good case can be made that we don't give it the attention or respect it actually deserves. Food is central to human life, and how we go about the process of cr...

17 Maj 20211h 16min

AMA | May 2021

AMA | May 2021

Welcome to the May 2021 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of questio...

13 Maj 20212h 58min

146 | Emily Riehl on Topology, Categories, and the Future of Mathematics

146 | Emily Riehl on Topology, Categories, and the Future of Mathematics

"A way that math can make the world a better place is by making it a more interesting place to be a conscious being." So says mathematician Emily Riehl near the start of this episode, and it's a good ...

10 Maj 20211h 16min

145 | Niall Ferguson on Histories, Networks, and Catastrophes

145 | Niall Ferguson on Histories, Networks, and Catastrophes

The world has gone through a tough time with the COVID-19 pandemic. Every catastrophic event is unique, but there are certain commonalities to how such crises play out in our modern interconnected wor...

3 Maj 20211h 25min

144 | Solo: Are We Moving Beyond the Standard Model?

144 | Solo: Are We Moving Beyond the Standard Model?

I've been a professional physicist since the 1980's, and not once over the course of my career has a particle-physics experiment produced a completely surprising new result. We've discovered particles...

26 Apr 20211h 11min

143 | Julia Galef on Openness, Bias, and Rationality

143 | Julia Galef on Openness, Bias, and Rationality

Mom, apple pie, and rationality — all things that are unquestionably good, right? But rationality, as much as we might value it, is easier to aspire to than to achieve. And there are more than a few h...

19 Apr 20211h 32min

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