234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


Avsnitt(411)

317 | Nicole Rust on Why Neuroscience Hasn't Solved Brain Disorders

317 | Nicole Rust on Why Neuroscience Hasn't Solved Brain Disorders

The human brain is extremely complicated, but decades of careful neuroscientific research have revealed quite a bit about how it works, including how certain genes affect particular brain behaviors. N...

9 Juni 20251h 14min

AMA | June 2025

AMA | June 2025

Welcome to the June 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreo...

2 Juni 20253h 23min

316 | Niayesh Afshordi and Phil Halper

316 | Niayesh Afshordi and Phil Halper

Einstein's general theory of relativity, plus some reasonable assumptions about the universe and what it's made of, has a remarkable implication: that as we trace cosmic evolution into the far past, w...

26 Maj 20251h 28min

315 | Branden Fitelson on the Logic and Use of Probability

315 | Branden Fitelson on the Logic and Use of Probability

Every time you see an apple spontaneously break away from a tree, it falls downward. You therefore claim that there is a law of physics: apples fall downward from trees. But how can you really know? A...

19 Maj 20251h 28min

314 | Karen Lloyd on the Deep Underground Biosphere

314 | Karen Lloyd on the Deep Underground Biosphere

There are living creatures dwelling deep below the surface of the Earth, as deep as we are able to drill. These hearty microorganisms are related to more familiar life forms on land and under water, b...

12 Maj 20251h 9min

313 | Eric Topol on the Changing Face of Medicine and Aging

313 | Eric Topol on the Changing Face of Medicine and Aging

Medical science is advancing at an astonishing rate. Today we talk with leading expert Eric Topol about two aspects of this story. First, the use of artificial intelligence in medicine, especially in ...

5 Maj 20251h 12min

AMA | May 2025

AMA | May 2025

Welcome to the May 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreon...

28 Apr 20253h 38min

312 | Thomas Levenson on the Mutual History of Humans and Germs

312 | Thomas Levenson on the Mutual History of Humans and Germs

The germ theory of disease is a crowning achievement of science, up there with modern physics, continental drift, and evolution via natural selection. (Even if there will always be cranky skeptics.) B...

21 Apr 20251h 31min

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