Sepsis in pregnant or recent pregnant patients recognition, Diagnosis & Mx

Sepsis in pregnant or recent pregnant patients recognition, Diagnosis & Mx

Suspected Sepsis in Pregnant and Recently Pregnant People: Recognition, Diagnosis, and Early Management

Executive Summary

Sepsis in the obstetric population is a life-threatening medical emergency requiring immediate recognition and intervention. This guideline (NICE NG255, 2025) replaces NG51 and provides a tailored framework for pregnant people and those who have been pregnant within the last six weeks.Critical Takeaways:

    • The 6-Week Window: Always consider sepsis in any person who is pregnant or has been pregnant (including miscarriage or termination) within the previous six weeks.
    • High-Risk Criteria: Identify "High Risk" status immediately using the stratified criteria (e.g., RR ≥ 25, HR > 130, SBP ≤ 90, or altered mental state).
    • The 1-Hour Bundle: For high-risk patients, the senior clinical decision-maker must assess, and broad-spectrum antibiotics must be administered within one hour.
    • Source Control: Active search for the infection source (including imaging of the abdomen and pelvis) is mandatory if the source is not immediately apparent.
    • Senior Involvement: Specific clinician grades are defined for senior review (ST3+ for adults, ST4+ for under 18s).


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