From seizures to Granulation Nation: The Unexpected Story of Phenytoin in Wound Healing

From seizures to Granulation Nation: The Unexpected Story of Phenytoin in Wound Healing

This episode traces how phenytoin — an anticonvulsant known for causing gingival overgrowth — was repurposed into a topical therapy for chronic wounds. It outlines the drug’s mechanisms in wounds: activating fibroblasts, increasing collagen synthesis, reducing MMP activity, modulating inflammation, and promoting granulation and angiogenesis in stalled diabetic foot ulcers.

Listeners will hear clinical implications, common formulations, and important cautions: topical phenytoin can aid healing in selected chronic ulcers but does not replace debridement, offloading, vascular optimization, or infection control, and should be avoided in malignant wounds, untreated osteomyelitis, or critical ischemia. The episode also highlights the drug’s history and future delivery innovations.

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Avsnitt(397)

Path of Least Resistance: The Battle to Save Diabetic Feet

Path of Least Resistance: The Battle to Save Diabetic Feet

In this episode Dr. G explains how the phrase "path of least resistance" applies to diabetic foot infections and why a small surface ulcer can hide extensive, limb‑threatening disease. He reviews surg...

8 Okt 32min

Particularly Peculiar Podiatry Series: Tiny Toe, Huge Threat: Inside Toe Pulp Infections

Particularly Peculiar Podiatry Series: Tiny Toe, Huge Threat: Inside Toe Pulp Infections

This episode explains toe pulp (felon) infections and why a tiny wound at the tip of the toe can become a serious problem, especially in people with diabetes and neuropathy. It covers causes (puncture...

7 Okt 26min

Restoring the Polarity of the Diabetic Foot Ulcer  The Bioelectric Signal That Tells a Wound Where to Heal

Restoring the Polarity of the Diabetic Foot Ulcer The Bioelectric Signal That Tells a Wound Where to Heal

Dr. G explores the idea that wounds carry bioelectrical signals that guide cell movement and repair, and that diabetes can disrupt these electrical instructions in diabetic foot ulcers. The episode re...

6 Okt 14min

Fat to the Rescue: Regenerating Diabetic Feet with Autologous Fat Grafting

Fat to the Rescue: Regenerating Diabetic Feet with Autologous Fat Grafting

Dr. G explores the potential of autologous fat grafting for diabetic foot ulcers, explaining how adipose-derived cells may aid angiogenesis, modulate inflammation, and restore soft-tissue padding to i...

5 Okt 20min

LIMBWatch Series- Jonathan Brocklehurst- Grandpa, Where Are Your Shoes? — The Question That Can Save Feet

LIMBWatch Series- Jonathan Brocklehurst- Grandpa, Where Are Your Shoes? — The Question That Can Save Feet

Episode Summary Where Are Your Shoes? Turning Family Conversations Into Diabetic Foot Surveillance | LIMBWatch with Jonathan Brocklehurst In this episode of LIMBWatch, Dr. Gabrielle Hutcheson Donaldso...

28 Sep 46min

Pinch Grafting: Tiny Skin, Big Impact on Diabetic Foot Wounds

Pinch Grafting: Tiny Skin, Big Impact on Diabetic Foot Wounds

In this episode Dr. G explains pinch grafting — a simple autologous technique that places tiny pieces of a patient’s own skin onto a prepared wound bed to create epithelial “islands” that promote clos...

27 Sep 25min

10 Habits Every Person with Diabetes Needs

10 Habits Every Person with Diabetes Needs

This episode of Diabetic Foot Files shares ten practical habits to prevent serious foot problems and limb loss in people with diabetes. The host emphasizes vascular assessment as the top priority and ...

23 Sep 17min

Silent Signals: Thirst, Fatigue, and the Diabetes You Didn’t Know You Had

Silent Signals: Thirst, Fatigue, and the Diabetes You Didn’t Know You Had

Dr. G explains how type 2 diabetes can develop quietly and describes common but often overlooked early signs — persistent thirst and urination, fatigue, blurry vision, recurrent infections, slow-heali...

22 Sep 14min

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