Pathophysiology of nerve damage in leprosy, part 2
The Peripheral Nerve Podcast21 Okt 2025

Pathophysiology of nerve damage in leprosy, part 2

In the second part of this episode, the focus shifts from molecular mechanisms to real-world pathology. Hosts Dr. Camila Pupe and Dr. Wilson Marques Jr. welcome back:

  • Professor Anuraa Rambukkana – whose groundbreaking research on Schwann cell reprogramming has transformed our understanding of how Mycobacterium leprae targets and reshapes peripheral nerves.
  • Dr. Bruno Dornelas – Neuropathologist at the Federal University of Uberlândia, with extensive experience in leprosy pathology.

Discussion highlights include:

  • Histopathological patterns across the Ridley-Jopling spectrum (from tuberculoid to lepromatous forms)
  • How pathology findings correlate with bacterial mechanisms and immune response
  • Predictors of relapse and treatment failure (e.g., persistent lymphocytic infiltrates, foamy granulomas, bacillary index, and anti-PGL-1 serology)
  • Challenges in defining "cure" and monitoring patients post-MDT
  • The need for better diagnostic tools for early and atypical presentations
  • Future translational directions, including regenerative strategies inspired by bacterial-host interactions

This episode underscores the spectrum nature of leprosy neuropathy, the importance of long-term monitoring, and opportunities for innovation in therapy and diagnostics.

Transcript

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Avsnitt(15)

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