Can AI Replace the Prostate Biopsy? The Future of Prostate Cancer Diagnosis with Dr. Wayne Brisbane

Artificial intelligence is transforming prostate cancer care faster than ever before but could it one day replace the traditional biopsy?

In this episode, Dr. Geo sits down with Dr. Wayne Brisbane, Assistant Professor of Urology and urologic oncologist whose research is helping redefine how prostate cancer is detected and treated. After earning his medical degree from Loma Linda University School of Medicine, completing his urology residency at the University of Washington, and a fellowship in Urologic Oncology at UCLA, Dr. Brisbane has become one of the leading voices in AI-driven prostate cancer diagnosis.

His clinical practice and research focus on image-guided biopsy, MRI, PSMA PET imaging, micro-ultrasound, and focal therapy—helping patients receive more precise treatment while minimizing unnecessary side effects. UCLA remains one of the few centers in the world advancing all of these technologies under one program.

Together, Dr. Geo and Dr. Brisbane explore how artificial intelligence is improving MRI interpretation, helping physicians better map prostate tumors, identify the best candidates for focal therapy, and potentially reduce the need for invasive biopsies in the future.

If you're navigating a prostate cancer diagnosis or simply want to understand where prostate cancer care is headed this conversation offers a fascinating look at the next generation of precision medicine.

Episode Chapters

00:00 Introduction

03:00 AI Is Changing Prostate Cancer Diagnosis

07:00 Unfold AI: Mapping Tumors with Greater Precision

10:00 Who Is the Right Candidate for Focal Therapy?

13:00 Life After Focal Therapy: MRI, PSMA & Monitoring

15:00 Focal Therapy vs. Surgery: What the Latest Research Shows

21:00 Can AI Eventually Replace the Prostate Biopsy?

25:00 Dr. Brisbane's Vision for the Future of Diagnosis

29:00 Cribriform Disease: Identifying High-Risk Cancer

32:00 Beyond DNA: How Proteomics May Transform Cancer Care

Key Takeaways

✅ How AI is making prostate cancer diagnosis more accurate

✅ Why MRI can still miss clinically significant prostate cancer

✅ The technology behind Unfold AI and personalized tumor mapping

✅ Who is—and isn't—a good candidate for focal therapy

✅ Why tumor size plays a critical role in treatment decisions

✅ Can AI eventually replace the prostate biopsy?

✅ The latest research comparing focal therapy and surgery

✅ Why prospective clinical trials matter when evaluating new treatments

✅ How MRI, PSMA PET, genomics, and AI are shaping the future of prostate cancer care

✅ Dr. Wayne Brisbane's vision for the next generation of precision prostate cancer diagnosis

Resources Mentioned

• Unfold AI (Avenda Health)
• MRI for prostate cancer
• PSMA PET imaging
• Focal Therapy
• Active Surveillance
• UCLA Prostate Cancer Research
• Stanford validation studies
• CAPTAIN Trial
• FARP Trial
• HIFU clinical studies

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⚠️ Disclaimer

This podcast is for educational purposes only and not medical advice. The views expressed are Dr. Geo’s and not those of his employer(s) or affiliated organizations. Use of this content is at your own risk. Geovanni Espinosa, N.D., assumes no liability for direct or indirect consequences, including economic loss, injury, illness, or death.