Brain Fog, Low Libido, Night Wakes with Hormone & GLP-1 Expert Jackie Giannelli

Why are women's health issues often brushed off as “just part of aging”?

In this eye-opening episode, Natassia sits down with board-certified family nurse practitioner, women's longevity and sexual medicine expert Jackie Giannelli to unpack the truth about perimenopause, menopause, libido, hormone replacement therapy, GLP-1 medications, hair loss, testosterone, vaginal estrogen, peptides, and sexual wellness. They explore why so many women feel dismissed when experiencing brain fog, fatigue, low desire, anxiety, and disrupted sleep and what can actually be done about it.

From the controversy surrounding hormone therapy and breast cancer fears to the surprising effects of GLP-1 medications on libido and pleasure, this conversation challenges outdated medical narratives and offers practical insights for women who want to reclaim their vitality, confidence, relationships, and long-term health. If you've ever wondered whether feeling “flat” is normal, this episode may change the way you think about aging and wellness.

00:00 – Welcome and introduction

01:15 – Why women feel dismissed by healthcare

02:58 – The first signs of perimenopause

05:25 – Sleep, libido, brain fog, and hormone decline

06:25 – Normal vs. optimal hormone levels

09:41 – Medical gaslighting and menopause care

11:32 – When hormones aren't the whole story

13:05 – Testosterone therapy for women

15:03 – Understanding estrogen, progesterone, and hormone balance

17:28 – Bioidentical vs. synthetic hormones

19:19 – The Women's Health Initiative controversy

22:04 – Breast cancer fears and hormone therapy

24:52 – Feeling flat, dopamine, and SSRIs

26:10 – GLP-1 medications and sexual side effects

29:20 – Combining hormones with GLP-1 treatment

32:08 – Long-term concerns about GLP-1 medications

36:12 – Hair loss, hormones, and weight loss drugs

41:37 – Peptides explained

44:01 – The peptide regulation gray area

46:00 – PT-141, Addyi, and female libido treatments

51:16 – Why vaginal estrogen is underused

54:13 – Designing a home for intimacy and connection

57:08 – The science of music and arousal

59:00 – Closing thoughts

Follow Jackie Giannelli on Instagram

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