220. Is plant-based dead? Paul Saladino MD on Radical Health Radio

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be  amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.    He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.   Time Stamps:   0:08:46  Podcast Begins 0:14:21  The Bradford Hill Criteria 0:15:29  Context matters in lipids 0:19:44  Carnivore MD's Lipid Panel 0:30:15  Why LDL can't be the root cause of CVD 0:35:57  Testing the Lipid Hypothesis  0:41:20  Why you can't look at LDL in a vacuum 0:47:38 High-density lipoprotein as a protective factor against coronary heart disease The Framingham study - The Framingham Study  https://www.amjmed.com/article/0002-9343(77)90874-9/pdf 0:49:19  Metabolic health is what really matters 0:52:01  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:54:19  LDL quality is what actually matters 1:00:39  What's the root cause of oxidized LDL?   1:06:20  Why most LDL lab tests are bonk! 1:07:41  Dave's latest experiment results 1:16:12  Summary of Dave's Energy Model 1:21:21  The body holds onto and reuses cholesterol. 1:24:28  The vital importance of ample cholesterol 1:25:40  Fasting Increases Serum Total Cholesterol, LDL Cholesterol and Apolipoprotein B in Healthy, Nonobese Humans  https://academic.oup.com/jn/article/129/11/2005/4721856 1:26:19  Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis ­Despite Highly Elevated Plasma Lipids during Hibernation and Active State  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439871/ 1:28:40  Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients  <a href= "https://pubme

5 Okt 20201h 50min

In case you needed more reasons to love Suet (and tallow) allow me to share with you a few more studies showing some really cool benefits including colon cancer prevention in animal models, and odd chain fatty acids like C:15 (pentadecanoic acid) which appear to have significant health benefits that are found only in animal foods! Nose to tail for the win yet again!    Welcome to The Remembering...    Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life!

2 Okt 20208min

Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then.   Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life.   The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable, but treatable in the early to moderate stages, with an ancestral diet.   Time stamps:   0:11:08 Podcast Begins 0:12:15 Chris Knobbe's Background 0:19:07 The History of macular degeneration and human diets 0:37:32 Chronic illness and obesity was once virtually nonexistent  0:48:41 When did PUFAs come onto the scene? 0:55:40 Increase in adipose tissue linoleic acid of US adults in the last half centuryhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/ 0:57:18 Is olive oil healthy? 0:58:47 PUFA's are the cause of chronic illness 1:02:29 The best health advice anyone could give 1:09:35 Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Micehttps://www.researchgate.net/publication/265650090_Dietary_Stearic_Acid_Leads_to_a_Reduction_of_Visceral_Adipose_Tissue_in_Athymic_Nude_Mice 1:14:41 Why you need animal fats 1:17:32 Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in micehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180905/ 1:18:41 Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colonhttps://pubmed.ncbi.nlm.nih.gov/15572298/ 1:21:56 Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ 1:23:26 Fat and essential fatty acid in mammary carcinogenesishttps://academic.oup.com/ajcn/article-abstract/45/1/218/4694942?redirectedFrom=fulltext <span style="font-weigh

28 Sep 20201h 59min

Animal-based diets, like a nose to tail carnivore diet, are about much more than food. They are a stepping stone to remembering where we have come from as humans.    Forgetting this history has led to myriad health and social ills today.   Check us out at www.Heartandsoil.co for the finest desiccated organ pills out there- get more nose to tail nutrition and thrive! Firestarter and Gut & Digestion are out now in addition to Beef Organs and Bone Marrow & Liver.    You can also always email me at drpaul@heartandsoil.co with questions!

25 Sep 202011min

Karen Martel is a Transformational Nutrition Coach who is a leading expert in ancestral nutrition, weight loss resistance and women’s hormone health. Host of the top-rated women’s health podcast The Other Side of Weight Loss and founder of the revolutionary program OnTrack, a membership community that has helped thousands of women to balance their hormones and lose weight. After struggling with her own health issues, Karen was determined to bring her knowledge to others with a bold new approach to women’s health and weight management. Karen's passion lies in helping women breakthrough weight loss resistance and find their personal weight loss code through hormone optimization. Karen is a health leader and researcher determined to revolutionize weight loss for modern women and men.     Time Stamps:   0:10:43 Podcast begins 0:12:56 Karen's story 0:22:06 Breaking down the menstrual cycle 0:35:50 Reasons for weight-gain 0:40:15 Heavy metal toxicity 0:52:36 Is environmental toxicity really the problem? 0:56:30 The onset of perimenopause 1:00:11 Effects of Macronutrient Distribution on Weight and Related Cardiometabolic Profile in Healthy Non-Obese Chinese: A 6-month, Randomized Controlled-Feeding Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672080/ 1:04:39 The progesterone steal and the importance of LDL 1:12:05 Low carb diets  1:16:18 Low carb is no panacea 1:19:17 Addressing the root cause of metabolic dysfunction 1:23:44 Carbohydrate and workout timing for women 1:27:33 How to structure a diet as a woman 1:32:07 Where zero carb goes all wrong 1:37:41 Where to find Karen Martel 1:38:27 Karen's radical hot springs adventure       Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram  Belcampo: www.belcampo.com Use the code “carnivoremd” for 20% off your order!  Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io,    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order</span

21 Sep 20201h 44min

Do the Hadza really consume 100g of fiber per day? Do we really know what a healthy gut microbiome is? Doubt it! When asked to rank their preferences for food (their diets are essentially meat, honey, berries, baobab fruit, and tubers) they consistently rank honey as their favorite and tubers last! In this video, I break down a number of articles looking at how the Hadza eat, their predilection for honey and meat, their oral health, and the seasonal cycling of their microbiota. I challenge the notion that we know what a "healthy" gut microbiome really is and suggest that this is better defined by clinical outcomes rather than myopic interpretations of individual species/phyla. I also share my own gut results on a nose to tail carnivore diet with honey in it.   Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life! Firestarter (our high stearic acid tallow from suet) and Gut & Digestion are out now.     You can also follow us at @heartandsoilsupplements on IG.

18 Sep 202033min

Brad Marshall is the author of the Blog Fire In A Bottle and the creator of The Croissant Diet.  Mildly obsessed with food and its history, his work focuses on trying to place current ideas about diet, including keto and carnivore diets into the framework of traditional Dietary patterns.     Brad has a genetics degree from Cornell, a certificate from The French Culinary Institute, has studied cancer at Memorial Sloan-Kettering Cancer center and worked as a programmer for the Berkeley Drosophila Genome Project.  He spent the last 15 years raising rotationally grazed pastured pork on his farm in upstate New York while running a butcher shop, local food restaurant and USDA inspected meat processing facility.   Brad is also the founder of Firebrand Meats, which is dedicated to producing pork and poultry products that are low in Linoleic acid, the n6 polyunsaturated fat (PUFA) whose intake has seen a dramatic worldwide increase in the last century.     https://reddit.com/r/SaturatedFat    Time Stamps: 0:13:55 Podcast Begins 0:15:14 Emmy's story https://fireinabottle.net/emmys-story/ 0:15:16 Change your fat, change your life 0:20:55 Disastrous Trends In American Bacon    https://fireinabottle.net/polyunsaturated-fat-pufa-in-pork-and-chicken/ 0:23:55 The problem with pork and chicken in the US 0:30:12 Brad's fascinating background 0:36:19 The croissant diet 0:45:27 Stearic acid vs linoleic acid 0:47:32 Plateaus on a ketogenic diet 0:53:54 Linoleic acid is the likely culprit 0:55:25 The shortcomings of the ketogenic understanding   0:58:58 The feasting mimicking diet 1:04:46 ROS is Satiation https://fireinabottle.net/ros-is-satiation/ 1:08:18 How linoleic acid affects blood glucose and satiety <s

14 Sep 20202h 29min

Stearic acid is an 18 carbon saturated fat that has intriguing effects on the human body. It's been shown to positively affect mitochondrial activity, and diets that are low in cause mitochondria to change activity and phenotype in negative ways. Mouse models of this fatty acid also suggest some profoundly powerful effects on glucose tolerance and visceral fat when compared to oleic acid (18C monounsaturated fat), and linoleic acid (18C polyunsaturated fat). I break it all down in this video and share my RBC fatty acid levels as well as a compelling n=1 case study of Emmy's weight loss with dietary shifts away toward more stearic acid and less linoleic acid.    Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life! Firestarter (our high stearic acid tallow from suet) and Gut & Digestion release this week!    You can also follow us at @heartandsoilsupplements on IG.   Controversial thoughts: How to get Omega-3 without Rancid Fish Oil and why Linoleic acid makes you Fat.  With levels of linoleic acid consistent with our evolutionary past, omega-3s aren't an issue if you are eating nose to tail! I also talk about CLA, how linoleic acid makes you fat. Check us out at www.heartandsoil.co  and @heartandsoilsupplements on instagram to get nose to tail nutrition!

11 Sep 202023min