#560: Building a Research OS: From Django to 30,000 Samples

#560: Building a Research OS: From Django to 30,000 Samples

In 2020, a gastroenterologist in Glasgow did the math on his new research study and came up with 30,000 samples, arriving over two years from three cities and a dozen hospitals. He asked around about how researchers keep track of that. The answer was Microsoft Excel. Shaun Chuah had written some HTML by hand in Notepad back in high school and that was about the whole of his programming experience, so he opened the Django tutorial and started reading. Six years later that app is Foundry120, holding 10 terabytes of clinical and genomics data with an agentic AI running on top of it.

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#567: Personal AI Agents for Pythonistas

#567: Personal AI Agents for Pythonistas

The most popular Python project you've probably never heard of has 252,000 GitHub stars and merged over 1,800 pull requests in a single week. It's Hermes, a self-hosted AI agent you program just by ta...

27 Okt 1h 6min

#566: State of the art in Python 2026

#566: State of the art in Python 2026

Which of your Python tools would you still pick if you started fresh today? For a long time, the answer was easy. The stack felt settled. AI has reopened almost every one of those choices. Some tools ...

17 Okt 1h 5min

#565: Tachyon, Python 3.15's Built-in Sampling Profiler

#565: Tachyon, Python 3.15's Built-in Sampling Profiler

Do you know what's actually slow in your Python app? Or are you guessing? Until now, profiling Python meant a tracing profiler that made your code 2 to 3 times slower. Or a third-party tool that broke...

2 Okt 1h 27min

#564: EVE Online Departs for Python 3

#564: EVE Online Departs for Python 3

Every ship in EVE Online eventually undocks and leaves the station. This time, it's the whole game. EVE has run on Python 2 since it launched in 2003, all 2.4 million lines of it, on a custom Stackles...

22 Sep 1h 7min

#563: Getting Started with Rust as Python Devs

#563: Getting Started with Rust as Python Devs

Lint the entire CPython code base from scratch. It takes 0.3 seconds. Three blinks of an eye. That is ruff, and it is written in Rust. So are Pydantic, Polars, uv, and Granian. Rust shows up in Python...

16 Sep 1h 10min

#562: DuckLake: The Lakehouse That's Just SQL and Parquet

#562: DuckLake: The Lakehouse That's Just SQL and Parquet

How many files does your query read before it reads any data? On some data lakes, you go through JSON and metadata files first, just to learn which Parquet files matter. DuckLake asks one SQL question...

10 Sep 1h 11min

#561: TonIO, a Multi-threaded Async Runtime for Python

#561: TonIO, a Multi-threaded Async Runtime for Python

How many cores does your machine have, 10, 18? Your async Python code uses just one of them. That isn't a bug in asyncio. That's the design, and optimizing event loops to be faster by 20% doesn't chan...

4 Sep 1h 15min

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