Hubble Not-So Constant, Synthetic E. Coli, The Adventures of Alexander von Humboldt

Hubble Not-So Constant, Synthetic E. Coli, The Adventures of Alexander von Humboldt

The Hubble Constant The Hubble constant is the current expansion rate of the universe but it seems to have changed over time. Hiranya Peiris, Professor of Astrophysics from University College London and Adam Riess, Professor of Physics and Astronomy from Johns Hopkins University, are both using different methods to obtain a value for the Hubble constant. But there is a discrepancy in their values. It used to be that the error bars on the two values overlapped, and so cosmologists thought they would converge as the experiments got more precise. But instead, as the error bars have shrunk, the discrepancy is getting more serious, and something must be wrong. They chat to Adam about potential reasons for this difference in calculations and what it could mean for our cosmological model of the universe. Is new physics required to evolve the description of the age of the universe as we know it to be more accurate?

A synthetic E. Coli genome Jason Chin and Colleagues at the Laboratory of Molecular Biology in Cambridge have published this week in the Journal Nature their latest work to completely synthesise a new genome of an E. coli bacteria. Not only was the genome designed and manufactured by human means, it was also recoded in a way not used by nature, involving some 18000 edits. In natural DNA, several different codes can do the same job. As Roland Pease reports, the new genome instead uses fewer of these duplicates, demonstrating all sorts of possibilities for future designs of synthetic cells.

Von Humboldt Friedrich Wilhelm Heinrich Alexander von Humboldt was a celebrated Prussian geographer, naturalist and explorer. He influenced Darwin and was the first person to describe human-induced climate change, based on his observations from his travels. Yet he has slipped into relative obscurity, at least in the English-speaking world.

Andrea Wulf is an acclaimed author who has previously written about Alexander von Humboldt and is now back with another book about the explorer: The Adventures of Alexander von Humboldt. It’s a graphic novel (illustrated by Lillian Melcher) that celebrates the 250th anniversary of Humboldt’s birth and depicts his adventures on his 5 year expedition through South America. Adam Rutherford chats to Andrea about her book, why she chose to make it a graphic novel and how Humboldt’s views on the environment can be interpreted today.

Producer: Alex Mansfield

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Universal flu vaccine; Science games; AllTrials; Penguin camera

Universal flu vaccine; Science games; AllTrials; Penguin camera

Influenza causes up to five million cases of severe illness and half a million deaths globally every year. Yet, as Adam Rutherford finds out, our current vaccination strategy is a seasonal game of chance, based on guessing the strain that will appear next. Research published this week in Science Translational Medicine, by a team from Mount Sinai Hospital in New York, offers hope for a universal flu vaccine, based on newly discovered antibodies.Earlier this week, a game to help combat ash dieback was launched on Facebook, called Fraxinus. Reporter Gaia Vince looks at the growing trend for using games to solve scientific problems. Is this new way of gathering and analysing data changing the way science is done?Currently half of all clinical trials are not published worldwide. Adam talks to Ben Goldacre, author of Bad Pharma, about his new campaign 'AllTrials', which aims to change that.Finally this week, physicist Peter Barham shows us his instrument - a spy camera system that he's designed to recognise penguins.

15 Aug 201327min

Lab-grown leather; Goal line technology; Bacteria outrage; Marine buoy

Lab-grown leather; Goal line technology; Bacteria outrage; Marine buoy

Cultured meat was on the menu earlier this week, but Mark Post's public tasting of his lab-grown burger marks the culmination of decades of research on producing artificial meat. Adam Rutherford talks to one of the other major players in the world of manmade animal products, Gabor Forgacs. However, his company, Modern Meadow, is concentrating on launching a different product first - cultured leather.The football season is about to start, and for the first time electronic Goal Line Technology will be introduced. This year will see the Hawk-Eye system deployed at all Premier League grounds in an attempt to help referees make more informed decisions. But how will it work, and how accurate can it be? Inside Science speaks with the inventor, Paul Hawkins, and the engineers who are testing it to international standards.A bacteria or a bacterium? We sparked a controversy on last week's programme by using bacteria to describe a singular microbe. Adam talks to evolutionary biologist Mark Pagel about how words evolve and whether scientists can halt their adaptation.This week on 'Show Us Your Instrument', oceanographer Helen Czerski introduces her giant marine buoy. She'll be sailing into the eye of a storm just off the south coast of Greenland later this year, where the buoy will measure bubbles to help refine climate models.

8 Aug 201327min

Crash risk; Mary Rose bacteria; History of Science; Greenwich telescope

Crash risk; Mary Rose bacteria; History of Science; Greenwich telescope

July has seen train crashes in Canada, Pakistan, France, Spain and Switzerland. Inside Science asks if this is a trend or just a coincidence. Professor David Spiegelhalter, an expert in the public perception of risk, explains whether there is such a thing as a 'crash season'. Microbiologists working on the Mary Rose in Portsmouth have discovered a new type of metal-eating bacteria which is damaging the ship's wooden timbers. Reporter Gaia Vince goes behind the scenes at Portsmouth's Historic Dockyards to find out how conservation scientists have saved the ship. Last week Manchester hosted the 2013 International Congress of History of Science Technology and Medicine, the biggest ever meeting of historians of science from around the world. The keynote speech was given by Prof Hasok Chang of the University of Cambridge, urging his colleagues to put "Science back in History of Science". Inside Science asked him if there should also be more history in the practice of science... Finally, Dr Marek Kukula Public Astronomer at the Greenwich Observatory shows us his instrument - the 28inch refracting telescope which historians at the time likened to a Spanish onion, or the Taj Mahal.

1 Aug 201327min

2D supermaterials; Inside an MRI; Antarctic architecture

2D supermaterials; Inside an MRI; Antarctic architecture

Nobel Prize and - as of this week, Copley Medal - winner Andre Geim outlined in Nature today his vision for the next generation of super-materials. Chemist Prof Andrea Sella joins Adam to explain how the discovery of graphene may have been the start of a remarkable new class of tailor made materials technically known as 'Van der Waals heterostructures'.This week on Show Us Your Instrument, Prof Sophie Scott introduces the MRI machine and explains why you never press the 'quench' button, unless you want to blow the roof off.Finally, an exhibition on Antarctic architecture opens on Friday 26th July in Glasgow, commissioned by the British Council and curated by The Arts Catalyst. We talk to Hugh Broughton who designed the new Halley VI base, a Thunderbirds inspired building, perched on top of stilts, on top of skis.Plus, Adam calls the current Halley Base Commander, Agnieszka Fryckowska, to find out what it's like to live and work during three months of darkness.Producer: Michelle Martin.

25 Juli 201327min

Animal research; Astronaut selection; Show us your instrument

Animal research; Astronaut selection; Show us your instrument

This week saw the publication of the annual government statistics on scientific research on animals. Overall, it again shows an increase, but does that tell the whole story? Wendy Jarrett of the organisation Understanding Animal Research shares her thoughts.We hear from amateur and professional would-be astronauts about their training regime and selection process from Major Tim Peake, the UK’s next astronaut, to science broadcaster, Sue Nelson.Plus, the first in our new series ‘Show Us Your Instrument’. Material scientist Mark Miodownik introduces the wonders of the Transmission Electron Microscope, with music composed by the New Radiophonic Workshop.

18 Juli 201329min

Bioscience to bioweapons; Synthetic diamonds; Stem cell transplants

Bioscience to bioweapons; Synthetic diamonds; Stem cell transplants

Scientists investigate viruses in order to save lives. But could that same knowledge also help other people create dangerous viruses to use as weapons of terror?This Thursday evening, a public debate is being held by the Society of Biology around these issues of "Dual Use" research. In an age of synthetic biology, mail order genes, and open access publication, what are the pros and cons of sharing virology research?Also this week, a new centre for research into synthetic diamonds was opened by UK Science Minister David Willetts. Inside Science reporter Marnie Chesterton took a tour of the new facility to find out how diamonds might be a quantum computer's best friend.Plus, the first formal trial of a stem cell based organ transplant is happening in the UK. Martin Birchall from University College London is working on replacing the larynx. But if a patient receives a new voicebox from a donor, whose voice will they have?

11 Juli 201328min

Bovine TB; Coral sunscreen; Space junk

Bovine TB; Coral sunscreen; Space junk

Today the government announced a plan to rid England of bovine TB within 25 years. Adam Rutherford looks back at how this issue has evolved and the extent to which scientific evidence has informed the eradication strategies, from culling badgers to vaccination programs.Pharmacognosy is the study of medicines found in nature. Reporter Gaia Vince travels to the seaside to find out how corals could save us from sunburn in summers to come.There are an estimated 23,000 pieces of space junk around the size of a tennis ball floating above us. But there are millions of smaller bits of flotsam and jetsam, from the exploded rocket debris to fleck of paints. Even a 1cm bit of space debris could deliver the same energy as a car impacting on a concrete wall at 30 miles per hour.

4 Juli 201327min

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