#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined by Sarah Kennedy of CaloCurb, a remarkable veterinarian-turned-nutrition expert who brings decades of hands-on research and real-world insight to the weight loss conversation. Sarah shares her unique journey from studying animal nutrition—where performance and health are paramount—to spearheading groundbreaking human clinical trials in appetite regulation, hunger hormones, and innovative, natural GLP-1 strategies. Learn more about Calocurb at https://www.calocurb.com/?sca_ref=12093749.1gzbGYmTyb and use code NAT for 10% off. Episode Timestamps: Welcome and gratitude for listeners ... 00:00:00 Calocurb and GLP-1 context ... 00:02:07 Bitter taste receptors and appetite suppression ... 00:17:13 Discovery of hops as key bitter extract ... 00:20:13 Human trials: hormone changes and calorie reduction ... 00:21:00Comparison to pharmaceutical GLP-1s ... 00:21:44 Appetite studies: women vs. men ... 00:25:15 Recent clinical trial: fat loss, muscle preservation ... 00:28:37 Mechanisms: natural vs. synthetic hormone activation ... 00:31:38 Lasting effects after stopping Calocurb ... 00:34:16 Practical use cases: intermittent fasting, holidays, maintenance ... 00:36:33 Comparison: behavioral effects and food noise ... 00:37:03 Side effects: GI motility, constipation, and laxative effect ... 00:45:03 Calocurb vs. other "GLP-1" supplements ... 00:51:53 Blood sugar effects and limitations ... 00:55:51 Managing late eating and habit change ... 00:59:10 Safety considerations (GI conditions, pregnancy) ... 01:03:23 Older adults, menopause, and ongoing research ... 01:04:50 PYY, muscle satellite cells, and aging ... 01:07:36 Why it's hard to "just use food" for appetite control ... 01:08:41 Coming off pharmaceuticals: rebooting gut-brain axis ... 01:10:25 Open research questions and clinical focus ... 01:12:30 Natural vs. synthetic: critical difference explained ... 01:14:26 Sarah Kennedy's personal experience with food and Calocurb ... 01:16:16 Our Amazing Sponsors: Ozlo Sleepbuds 2 Sleepbuds 2- use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT for $20 off Sleepbuds 2. Countdown Insiders by Countdown — Join a community helping fund groundbreaking mitochondrial research while receiving exclusive events, science briefings, partner perks, and a voice in what Countdown does next. Get your first month free with code NATHALIE at joincountdown.org/membership. Nature's Marvels Bioregulators by Profound Health - Natural bioregulators designed to support your body's own cellular communication and healthy aging, with targeted formulas for everything from Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode