ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

Is immune checkpoint inhibitor (ICI)-associated myocarditis the same disease when it occurs early versus months after starting cancer therapy? Host Mitsuaki Sawano, MD, and co-host Shun Kohsaka, MD, welcome Kazuaki Maruyama, MD (Mie University), Shiro Nakamori, MD (Mie University), and Yuichi Tamura, MD (International University of Health and Welfare) to discuss their recent JACC: CardioOncology study examining inflammatory cell profiles in early- and late-manifestation ICI myocarditis. Using endomyocardial biopsy specimens from 35 patients across 11 Japanese centers, the investigators found substantially greater T-cell and macrophage infiltration in early cases, while late-manifestation cases showed less myocardial inflammation despite similar fibrosis and LVEF. We discuss whether timing may identify different inflammatory phenotypes, why clinical severity does not necessarily reflect the degree of myocardial inflammation, and the difficult clinical question of whether ICI therapy should always be permanently discontinued after suspected myocarditis. Finally, we explore how Japan’s unique experience with myocardial biopsy helped uncover these differences and whether carefully selected patients with late, milder presentations might eventually be considered for ICI rechallenge, while recognizing the hypothesis-generating nature of these findings.

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Avsnitt(93)

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

Is immune checkpoint inhibitor (ICI)-associated myocarditis the same disease when it occurs early versus months after starting cancer therapy? Host Mitsuaki Sawano, MD, and co-host Shun Kohsaka, MD, w...

3 Nov 34min

Does PFA Reach the Vein of Marshall? | JACC Baran

Does PFA Reach the Vein of Marshall? | JACC Baran

Does pulsed field ablation (PFA) for pulmonary vein isolation affect structures beyond the pulmonary veins? Host Mitsuaki Sawano, MD, welcomes Yosuke Nakatani, MD (Gunma University) to discuss his rec...

27 Okt 36min

A SELUTION to Paclitaxel DCB Complications in PAD? | JACC Baran

A SELUTION to Paclitaxel DCB Complications in PAD? | JACC Baran

Could sirolimus-coated balloons change how we treat femoropopliteal peripheral artery disease? Host Mitsuaki Sawano, MD, welcomes Yoshimitsu Soga, MD, PhD (Kokura Memorial Hospital) to discuss the 3-y...

20 Okt 28min

Proteomics in Action: Finding the Right Drug Targets for Ischemic Heart Disease | JACC Baran

Proteomics in Action: Finding the Right Drug Targets for Ischemic Heart Disease | JACC Baran

Which of the thousands of biomarkers associated with cardiovascular disease could actually become a useful drug target? Host Mitsuaki Sawano, MD, and co-host Nobuhiro Ikemura, MD, welcome Satoshi Yosh...

13 Okt 35min

PET Unmasks CMD: The Hidden Risk Behind Normal Perfusion | JACC Baran

PET Unmasks CMD: The Hidden Risk Behind Normal Perfusion | JACC Baran

Hosts Mitsuaki Sawano, MD, Satoshi Shoji, MD, and Kentaro Ejiri, MD, welcome Yoshito Kadoya, MD, PhD (University of British Columbia / St. Paul’s Hospital) to discuss his JACC: Cardiovascular Imaging ...

6 Okt 36min

Rethinking Health Care at Home and Abroad: Lancet RH Western Pacific Special | JACC Baran

Rethinking Health Care at Home and Abroad: Lancet RH Western Pacific Special | JACC Baran

Host Mitsuaki Sawano, MD, welcomes Shuhei Nomura, PhD (Tohoku University), Lisa Yamasaki, MD (Harvard T.H. Chan School of Public Health), and Haruka Sakamoto, MD, PhD (St. Luke’s International Hospita...

29 Sep 39min

PFA Changes the Game and the AT Circuit | JACC Baran

PFA Changes the Game and the AT Circuit | JACC Baran

Hosts Mitsuaki Sawano, MD, and Hiroyuki Sato, MD, welcome Kazutaka Nakasone, MD (Kobe University) to discuss his JACC: Clinical Electrophysiology study on atrial tachycardia (AT) after pulsed field ab...

22 Sep 36min

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