#13 - Deborah Mash: The Lioness of Ibogaine Research

#13 - Deborah Mash: The Lioness of Ibogaine Research

Dr. Deborah Mash is a pioneering researcher of ibogaine and one of the world’s foremost experts on the drug. She is a professor (emeritus) of neurology and molecular and cellular pharmacology at the University of Miami School of Medicine, and the founder and CEO of DemeRx, a company developing treatments for opioid use disorder.

What we discuss:


  • How Dr. Mash first became interested in ibogaine, including her connection to Howard Lotsof, an early ibogaine advocate

  • The structure of the ibogaine molecule and what makes it unique from other psychedelics

  • Dr. Mash’s early research: the first clinical studies of ibogaine in humans

  • Noribogaine: what it is and what it does

  • Ibogaine fatalities: is everyone who takes it is at equal risk of death?

  • How far have we come in terms of reframing our view of substance use disorder?

  • If ibogaine was rescheduled, what could the future of treatment look like?

Why it’s important:

In the excitement of the psychedelic renaissance, it can feel like all of this is “new.” It’s often said that there isn't enough research to support the use of ibogaine in a clinical setting, but Dr. Mash’s work is part of a growing body of evidence that proves otherwise. Reconciling her work and the stories you’ve heard on this show with the fact that ibogaine is still a Schedule I substance in the United States – meaning it has no medical value and a high potential for abuse – is hard to do. Understanding and working to change drug policy through research is a long game. We’re lucky that an expert like Dr. Mash is staying on the field.

Relevant Links:

Avsnitt(61)

#21 - The Power of Story at the Kentucky Opioid Use Disorder Summit

#21 - The Power of Story at the Kentucky Opioid Use Disorder Summit

In this episode, host Amanda Siebert recaps the recent Kentucky Summit on Exploring Breakthrough Therapeutic Potential for Opioid Use Disorder, which was held in La Grange, Kentucky on November 30. Th...

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#20 - Amy Fillinger: Can Ibogaine Help Codependency?

#20 - Amy Fillinger: Can Ibogaine Help Codependency?

Amy Fillinger is a travel agent and mom of three living in Arkansas. When Amy discovered ibogaine through social media, she assumed she’d learned about it to help her ex-husband who was suffering from...

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#19 - Tricia Eastman: Are We Responsible Psychedelic Stewards?

Tricia Eastman is an author, speaker, medicine woman, facilitator, and the founder of Ancestral Heart, a non-profit organization dedicated to the preservation and deeper understanding of ancient ritua...

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#18 - David Nassim: Keep Ibogaine Sustainable

#18 - David Nassim: Keep Ibogaine Sustainable

David Nassim is the co-director of Blessings of the Forest (BOTF), an organization that supports environmental and traditionalist associations, Indigenous communities and administrative authorities co...

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#17 - Dr. Gül Dölen: Can Ibogaine Open Critical Periods?

#17 - Dr. Gül Dölen: Can Ibogaine Open Critical Periods?

Dr. Gül Dölen, MD, PhD, is an associate professor of neuroscience at Johns Hopkins University. In her lab, her team focuses on how the brain enables social behaviors through basic neurobiological proc...

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#16 - Talia Eisenberg & Vianey Perez: The Intake Process

#16 - Talia Eisenberg & Vianey Perez: The Intake Process

Curious about the process of applying for ibogaine treatment? Want to know more about how staff screen potential clients? In this episode, Amanda Siebert is joined by two previous guests, Beond co-fou...

3 Aug 20231h 6min

#15 - The State of Ibogaine: A Psychedelic Science Recap

#15 - The State of Ibogaine: A Psychedelic Science Recap

This episode is a little different. Join host Amanda Siebert for an ibogaine-focused recap of the 2023 MAPS Psychedelic Science conference. This episode features audio clips from the closing ceremony ...

10 Juli 202330min

#14 - David Bronner: The Soap CEO Spearheading Psychedelics

#14 - David Bronner: The Soap CEO Spearheading Psychedelics

David Bronner is the CEO – that’s Cosmic Engagement Officer – of Dr. Bronner’s, a fifth-generation soap maker, and a board member of the Multidisciplinary Association of Psychedelic Studies. At the he...

29 Juni 202344min

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