Alzheimer's Disease, False Memory, Diamond Light Source, Twins in Space

Alzheimer's Disease, False Memory, Diamond Light Source, Twins in Space

Alzheimer's disease is becoming increasingly common as the global population ages. It is estimated that currently 44 million victims of Alzheimer's dementia exist in the world and that this will grow to more than 100 million cases by 2050. The announcement this week of the creation of the Drug Discovery Alliance - a network of labs to fast track dementia treatment aims to address the urgent need to identify drugs that prevent, slow the progression, or improve the symptoms of Alzheimer's. But what are the scientific hurdles and what's missing in our knowledge in fuelling an ambition to achieve a disease modifying therapy for dementia? Adam Rutherford speaks to Cambridge University neuroscientist Rick Livesey, and to Eric Karran, Director of Research at Alzheimer's UK

How is it possible to remember something initially and then change your account of the experience later on? Possibly, giant swathes of your own personal history are partially fictional if not completely false. The problem isn't that our memory is bad, but that we believe it isn't. Adam talks to forensic psychologist Julia Shaw whose astonishing new research examines the ability to implant completely made-up rich false memories into ordinary people in a lab setting and points to circumstances under which police officers can extract false confessions.

There's a visit to the UK's synchrotron light source at Harwell in Oxfordshire which since it started operations in 2007 has illuminating research on subjects ranging from Egyptology to virology and this year is opening its doors to the public

Adam meets Mark Kelly, one of NASA's twin astronauts taking part in a year-long space experiment to examine the impact of space travel using identical twins as subjects. With one twin orbiting on the International Space Station whilst the other remains confined to Earth, the aim is to examine how individuals with the same genetic profile respond to radically different environments - in particular the genomics of humans as they prepare to move away from their home planet.

Producer: Adrian Washbourne.

Avsnitt(614)

Lab-grown leather; Goal line technology; Bacteria outrage; Marine buoy

Lab-grown leather; Goal line technology; Bacteria outrage; Marine buoy

Cultured meat was on the menu earlier this week, but Mark Post's public tasting of his lab-grown burger marks the culmination of decades of research on producing artificial meat. Adam Rutherford talks to one of the other major players in the world of manmade animal products, Gabor Forgacs. However, his company, Modern Meadow, is concentrating on launching a different product first - cultured leather.The football season is about to start, and for the first time electronic Goal Line Technology will be introduced. This year will see the Hawk-Eye system deployed at all Premier League grounds in an attempt to help referees make more informed decisions. But how will it work, and how accurate can it be? Inside Science speaks with the inventor, Paul Hawkins, and the engineers who are testing it to international standards.A bacteria or a bacterium? We sparked a controversy on last week's programme by using bacteria to describe a singular microbe. Adam talks to evolutionary biologist Mark Pagel about how words evolve and whether scientists can halt their adaptation.This week on 'Show Us Your Instrument', oceanographer Helen Czerski introduces her giant marine buoy. She'll be sailing into the eye of a storm just off the south coast of Greenland later this year, where the buoy will measure bubbles to help refine climate models.

8 Aug 201327min

Crash risk; Mary Rose bacteria; History of Science; Greenwich telescope

Crash risk; Mary Rose bacteria; History of Science; Greenwich telescope

July has seen train crashes in Canada, Pakistan, France, Spain and Switzerland. Inside Science asks if this is a trend or just a coincidence. Professor David Spiegelhalter, an expert in the public perception of risk, explains whether there is such a thing as a 'crash season'. Microbiologists working on the Mary Rose in Portsmouth have discovered a new type of metal-eating bacteria which is damaging the ship's wooden timbers. Reporter Gaia Vince goes behind the scenes at Portsmouth's Historic Dockyards to find out how conservation scientists have saved the ship. Last week Manchester hosted the 2013 International Congress of History of Science Technology and Medicine, the biggest ever meeting of historians of science from around the world. The keynote speech was given by Prof Hasok Chang of the University of Cambridge, urging his colleagues to put "Science back in History of Science". Inside Science asked him if there should also be more history in the practice of science... Finally, Dr Marek Kukula Public Astronomer at the Greenwich Observatory shows us his instrument - the 28inch refracting telescope which historians at the time likened to a Spanish onion, or the Taj Mahal.

1 Aug 201327min

2D supermaterials; Inside an MRI; Antarctic architecture

2D supermaterials; Inside an MRI; Antarctic architecture

Nobel Prize and - as of this week, Copley Medal - winner Andre Geim outlined in Nature today his vision for the next generation of super-materials. Chemist Prof Andrea Sella joins Adam to explain how the discovery of graphene may have been the start of a remarkable new class of tailor made materials technically known as 'Van der Waals heterostructures'.This week on Show Us Your Instrument, Prof Sophie Scott introduces the MRI machine and explains why you never press the 'quench' button, unless you want to blow the roof off.Finally, an exhibition on Antarctic architecture opens on Friday 26th July in Glasgow, commissioned by the British Council and curated by The Arts Catalyst. We talk to Hugh Broughton who designed the new Halley VI base, a Thunderbirds inspired building, perched on top of stilts, on top of skis.Plus, Adam calls the current Halley Base Commander, Agnieszka Fryckowska, to find out what it's like to live and work during three months of darkness.Producer: Michelle Martin.

25 Juli 201327min

Animal research; Astronaut selection; Show us your instrument

Animal research; Astronaut selection; Show us your instrument

This week saw the publication of the annual government statistics on scientific research on animals. Overall, it again shows an increase, but does that tell the whole story? Wendy Jarrett of the organisation Understanding Animal Research shares her thoughts.We hear from amateur and professional would-be astronauts about their training regime and selection process from Major Tim Peake, the UK’s next astronaut, to science broadcaster, Sue Nelson.Plus, the first in our new series ‘Show Us Your Instrument’. Material scientist Mark Miodownik introduces the wonders of the Transmission Electron Microscope, with music composed by the New Radiophonic Workshop.

18 Juli 201329min

Bioscience to bioweapons; Synthetic diamonds; Stem cell transplants

Bioscience to bioweapons; Synthetic diamonds; Stem cell transplants

Scientists investigate viruses in order to save lives. But could that same knowledge also help other people create dangerous viruses to use as weapons of terror?This Thursday evening, a public debate is being held by the Society of Biology around these issues of "Dual Use" research. In an age of synthetic biology, mail order genes, and open access publication, what are the pros and cons of sharing virology research?Also this week, a new centre for research into synthetic diamonds was opened by UK Science Minister David Willetts. Inside Science reporter Marnie Chesterton took a tour of the new facility to find out how diamonds might be a quantum computer's best friend.Plus, the first formal trial of a stem cell based organ transplant is happening in the UK. Martin Birchall from University College London is working on replacing the larynx. But if a patient receives a new voicebox from a donor, whose voice will they have?

11 Juli 201328min

Bovine TB; Coral sunscreen; Space junk

Bovine TB; Coral sunscreen; Space junk

Today the government announced a plan to rid England of bovine TB within 25 years. Adam Rutherford looks back at how this issue has evolved and the extent to which scientific evidence has informed the eradication strategies, from culling badgers to vaccination programs.Pharmacognosy is the study of medicines found in nature. Reporter Gaia Vince travels to the seaside to find out how corals could save us from sunburn in summers to come.There are an estimated 23,000 pieces of space junk around the size of a tennis ball floating above us. But there are millions of smaller bits of flotsam and jetsam, from the exploded rocket debris to fleck of paints. Even a 1cm bit of space debris could deliver the same energy as a car impacting on a concrete wall at 30 miles per hour.

4 Juli 201327min

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