1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

John Brennan (@JohnBrennan) served as the Director of the CIA from 2013 to 2017, and is the author of Undaunted: My Fight Against America's Enemies, At Home and Abroad. What We Discuss with John Brennan: The mechanics of being in charge of America's spy agency and dealing with international crises on a daily basis. How CIA officers are taught to question their assumptions and overcome confirmation biases to find facts in a field of deception. Why John argued for diversity within the CIA -- not to placate a liberal agenda, as his critics asserted, but to strengthen the agency's ability to operate effectively in a diverse world. How John was able to get a job at the CIA in spite of past hashish use, lying to his mother about going to church, and voting for a communist. The challenges of operating clandestinely in the digitally rich 21st century. And much more... Full show notes and resources can be found here: jordanharbinger.com/458 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Jan 20211h 21min

You and your wife of four years have had your ups and downs, but she recently revealed her belief in a number of conspiracy theories. Now you wonder if you can continue a life together when you're living in two entirely different realities. We'll examine this rabbit hole and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/457 On This Week's Feedback Friday, We Discuss: Your wife of four years recently revealed she's gone down a conspiracy theory rabbit hole from which she may never return. Is it possible for your marriage to continue when you're each living in your own reality? [Thanks to Justin Ramsdell for helping us with this one!] You're the top choice to run operations if your company's acquisition goes through, but your priorities have shifted toward family and you're not sure the new bosses will understand your desire for work/life balance. What’s the best way to discuss your personal plans with the team so you feel your mutual needs are being considered? [Thanks to Michelle Tillis Lederman for giving us some insight here!] How should a financially smart, successful couple entertain the idea of cohabitating when marriage is in the plans down the road, but the relationship hasn't yet passed the one-year mark? You're friends with a family who recently started hosting maskless "freedom rallies" that have drawn thousands of people into tight quarters during this global pandemic. Every reason you've expressed to them for why this is a terrible idea has been dismissed. Should you just give up? And is there even a future for your friendship even after this passes? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Jan 202145min

Laura Nirider (@LauraNirider) is the co-director of the Center on Wrongful Convictions at Northwestern Pritzker School of Law, and the co-host of the Wrongful Conviction: False Confessions podcast. What We Discuss with Laura Nirider: Two to five percent of people currently serving time in prison have been falsely convicted. False confessions and admissions are present in 15 to 20 percent of all DNA exonerations. The United States is one of the only countries in the world that allows police to lie about evidence during interrogations. Why so many people are coerced into providing false confessions during interrogations that are gentle compared to the more "hands on" approach taken by police in decades past. How Laura is working to clean up interrogation techniques so they're still effective in solving crimes without trapping innocent people in the system. And much more... Full show notes and resources can be found here: jordanharbinger.com/456 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Jan 20211h 8min

Matthew McConaughey (@McConaughey) is an Academy Award-winning actor, producer, and author of  #1 New York Times Bestseller Greenlights. What We Discuss with Matthew McConaughey: What the sobriety of grief did for Matthew's attitude about risk when he was dealing with the loss of his father. How Matthew tries to instill the values of self-reliance in his kids. How Matthew learned to cope with imposter syndrome and get his head on straight when he became a household name seemingly overnight. The philanthropic approach to selecting roles that has guided Matthew through his career in film. How Matthew keeps criticism from affecting how he perceives himself. And much more... Full show notes and resources can be found here: jordanharbinger.com/455 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Jan 20211h 23min

You're in an online community that chats about erotic roleplay (ERP), and inadvertently engaged in conversation with a couple of minors. When you discovered their age, you immediately broke off contact -- but you're still worried this could have legal repercussions. Should you be concerned? We'll tackle this and more here on the first Feedback Friday of the year! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/454See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Jan 202154min

Javier Peña and Steve Murphy (@deanarcos) are former DEA agents best known for bringing down Colombian drug kingpin Pablo Escobar in the '90s, as dramatized on the first two seasons of Netflix series Narcos and chronicled in their book Manhunters: How We Took Down Pablo Escobar. What We Discuss with Javier Peña and Steve Murphy: How do you conduct an effective investigation against a murderous yet charismatic criminal on their home turf with a $300,000 bounty on your head? Why was there such friction between the DEA and the CIA during the Pablo Escobar investigation? Why do countries like Mexico and Colombia resist extradition to the United States when we catch a big fish drug trafficker? Have Javier and Steve been back to Colombia since bringing down Pablo Escobar, or do they still have to fear for their lives there? Do Javier and Steve see the permanent dismantling of drug cartels as a possibility, or are they too entrenched in the infrastructure of the countries where they thrive? And much more... Full show notes and resources can be found here: jordanharbinger.com/453 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Jan 20211h 12min

Welcome to Stereo Sunday, a little Stereo app-sponsored experiment we did live in front of a studio audience of you! This time around, we answered questions from listeners. It went a little something like this... Full show notes and resources can be found here: jordanharbinger.com/bonus-stereo-sunday On This Week's Stereo Sunday, We Discuss: You discovered -- and had to break the news -- that your mom's boyfriend was cheating on her, but she married him a few months later anyway. To your dismay, now she's having doubts. What can you do? As someone who's been dating for just a few months after a long-term relationship ended, why do you get attached so easily, and how do you avoid these feelings (at least until it's a mutual exchange)? You and your friend are both struggling with the mental and physical challenges that accompany type two diabetes, but she isn't as careful with her diet as you are and she seems genuinely puzzled that there are consequences. Is there a way to help your friend without being a nagging, self-righteous a-hole? If you've put your all into a business only to have it fail, how do you overcome the sting of this failure and drum up the courage to try again? You know you have the work experience to fill a job opening at your company, but your imposter syndrome kicks in when you read its prerequisites -- in particular, a degree you don't have. How can you make a case for your qualifications even though you don't check all the boxes on paper? What industries and potential side hustles have been positively affected by the COVID-19 pandemic and might be good opportunities for someone looking to pivot? You've been out of the workplace for so long that you're not sure where to even begin now that you're ready to get back into it. What's a good first step?  How do Fiverr, Upwork, and Mechanical Turk compare for freelancers looking to make a buck? Download the Stereo app here! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider leaving your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Jan 202152min

You and your direct boss had a secret affair, and he asked you not to disclose it to your company's vetting agency for fear of losing his security clearance. Now it's years later and you want to come clean to the agency, but how can you do so without it coming off as petty revenge? We'll tackle this and more here on the last Feedback Friday of 2020! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/452 On This Week's Feedback Friday, We Discuss: 2020's been a wild ride. Are we buckled up for 2021? You and your direct boss had a secret affair, and he asked you not to disclose it to your company's vetting agency for fear of losing his security clearance. Now it's years later and you want to come clean to the agency, but how can you do so without it coming off as petty revenge? When your uncle passed away suddenly, you felt remorse that you never tried to talk to him about the signs of depression he was showing. Now you don't want to make the same mistake with his son, who's clearly struggling with similar issues. But where do you even begin? You and your partner of five years recently split up after talking about how there isn't a path forward for you because opportunities forced you into a long-distance relationship -- even though you are still in love and so compatible otherwise. It feels like a wrong decision; how can you be sure you've explored every option? How might someone grasping at gratitude cultivate a more giving mindset? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider leaving your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Dec 202049min