1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

After treating his own rare disease, Chasing My Cure author David Fajgenbaum explains how existing drugs can help other sufferers survive the unknown.

What We Discuss with David Fajgenbaum:
  • Dr. David Fajgenbaum nearly died multiple times from a rare ailment called Castleman disease, for which there was no effective treatment available.
  • The current healthcare system does not incentivize pharmaceutical companies to find new uses for existing drugs, especially for rare diseases, leaving many potential treatments undiscovered.
  • Driven by his own experiences, Dr. Fajgenbaum realized that many existing FDA-approved drugs could be used to fight rare diseases for which they weren't originally intended.
  • Dr. Fajgenbaum founded Every Cure, a nonprofit organization that uses AI to match existing drugs with rare diseases they could potentially treat, greatly accelerating the process of finding cures.
  • You can make a positive impact by supporting organizations like Every Cure, which are working tirelessly to find treatments for rare diseases using innovative approaches. Consider donating to their cause, spreading awareness about their mission, or even sharing your own experiences with off-label drug use that has helped you or someone you know. Every contribution, no matter how small, can help bring hope and relief to those suffering from rare diseases.
  • And much more...

Full show notes and resources can be found here: jordanharbinger.com/1005

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Avsnitt(1266)

418: How to Deal with Unsolicited Underage Nudes | Feedback Friday

418: How to Deal with Unsolicited Underage Nudes | Feedback Friday

Even if you're a minor, the life-altering consequences of being caught with child pornography shared via sexting by a fellow minor can be dire. We'll tackle how to deal with unsolicited, underage nudes -- and much more -- here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/417 On This Week's Feedback Friday, We Discuss: Even if you're a minor, the life-altering consequences of being caught with child pornography shared via sexting by a fellow minor can be dire. Here's how to deal with unsolicited, underage nudes. [Thanks to our attorney friend Corbin Payne for helping us with this one!] After efficiently streamlining and automating the duties of your new job -- for which you got a hefty raise -- you find you're really only working 20 to 30 minutes per day. How can you come to terms with working smarter rather than harder without feeling like you're taking unfair advantage of your company? Your brother has little in the way of dating experience, and is now in a relationship with a recently divorced mother of two, 11 years his senior, who can most politely be described as "mean and controlling." How might you help him see for himself that he deserves better from a partner? You have a coworker who neglects aspects of her job in a way that could erode the public's trust in your profession. You genuinely like this coworker and don't want to destroy her life, so how can you get her to change her ways before resorting to bringing it to the boss' attention? In spite of making decent enough money with the business you co-founded, you've never felt comfortable playing the role of entrepreneur. Where do you look for opportunities and paths when you feel stuck and have exhausted your creativity? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Like this show? Please leave us a review here -- even one sentence helps! Consider leaving your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Okt 202056min

417: Dan Ariely | The Hidden Logic That Shapes Our Motivations

417: Dan Ariely | The Hidden Logic That Shapes Our Motivations

Dan Ariely (@danariely) is the James B. Duke Professor of Psychology and Behavioral Economics at Duke University and bestselling author of Predictably Irrational: The Hidden Forces That Shape Our Decisions and Payoff: The Hidden Logic That Shapes Our Motivations. What We Discuss with Dan Ariely: How does the What the Hell effect keep us making bad decisions even when we know they’re bad? Are we ever truly rational, unbiased, or impartial? What’s the best time to appear before a judge? How transparency in our lives can often backfire. How motivation works (and doesn’t work) and how we can use our own psychology against ourselves. And so much more... Full show notes and resources can be found here: jordanharbinger.com/417 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Okt 20201h 32min

416: John Perkins | New Confessions of an Economic Hit Man

416: John Perkins | New Confessions of an Economic Hit Man

John Perkins (@jperkinsauthor) is an economist who has advised the World Bank, United Nations, Fortune 500 corporations, and the US government. He is the author of The New Confessions of an Economic Hit Man. What We Discuss with John Perkins: How corporations and governments use economic hit men (like John in a previous life) to coerce developing countries to auction off their most valuable resources like rainforests, oil, and mines at bargain-basement prices. Why these predatory capitalist policies are commonplace and above scrutiny -- even though your tax dollars are massively subsidizing them. The dire consequences that transpire when the leaders of these developing nations refuse to play ball. How false economics, false promises, threats, bribes, extortion, debt, deception, coups, assassinations, and unbridled military power are used to dominate the developing world now more than ever before. What John has learned from his time inside this corrupt system that we can use to transform what he calls a Death Economy into a Life Economy. And much more... Full show notes and resources can be found here: jordanharbinger.com/416 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Okt 20201h 3min

415: Should I Dodge a Debt to the Mafia? | Feedback Friday

415: Should I Dodge a Debt to the Mafia? | Feedback Friday

You suspect your father-in-law took a large loan from the mafia in the Eastern European country where you now reside, and that they may come to you for it because you're American and they assume you're rich (which you're not). What can you do to keep your family safe? We'll field this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/415 On This Week's Feedback Friday, We Discuss: When you're stuck with a ceaseless sense of uncertainty (as many of us are in the midst of a pandemic), remember, in the words of the wise James Clear: action forces prioritization. You suspect your father-in-law took a large loan from the mafia in the Eastern European country where you now reside, and that they may come to you for it because you're American and they assume you're rich (which you're not). What can you do to keep your family safe? Texting “Did they pull the plug yet?” when your daughter was on life support a few months back was insensitive of your wife's friend. Should it be chalked up to an innocent lack of self-awareness, or is this a clear sign the friendship has run its course? You work in an industry that allows you a flexible schedule, teaches you new skills, and pays well. But you can't shake the desire to dabble in a craft industry that might be personally fulfilling -- only without your current perks. How can you ensure you've considered all the data before you make a decision you may regret? Can your reconnection with an old flame who already has kids endure if your plans to have a baby together are thrown off by lengthy unemployment and a loudly ticking -- and expiring -- biological clock? You're lucky enough to have work-funded coaching to help with personal and professional development, sleep, nutrition, navigating uncertainty, and communication for the next six months. What can you do to ensure you're making the most of this valuable -- but limited -- time? Recommendation: My Octopus Teacher on Netflix Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Okt 20201h 2min

414: Jonah Berger | How to Change Anyone's Mind

414: Jonah Berger | How to Change Anyone's Mind

Jonah Berger (@j1berger) is a professor at Wharton and a world-renowned expert on word of mouth, social influence, consumer behavior, and how products, ideas, and behaviors catch on. He's also a bestselling author; his latest book is The Catalyst: How to Change Anyone's Mind. What We Discuss with Jonah Berger: How the ingrained anti-persuasion radar we all possess makes it harder for us to follow even the best advice. Why providing someone with a "menu" of options is a far more effective method of persuasion than giving them a single option. While pushing works well when we want to move furniture, we're better off identifying obstacles and removing them when we want to guide another person in a certain direction. How effective advertising overcomes our anti-persuasion radar and gets us invested in the idea of buying products. Why most anti-smoking campaigns have an effect opposite of their intentions, and how a Thai campaign cleverly adopted a tactic that actually worked. And much more... Full show notes and resources can be found here: jordanharbinger.com/414 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Okt 20201h 5min

413: Mark Edward | True Confessions of a Fake Psychic

413: Mark Edward | True Confessions of a Fake Psychic

Mark Edward is a professional mentalist who specializes in magic of the mind -- including a convincing stint as a fake psychic. He's the author of Psychic Blues: Confessions of a Conflicted Medium. What We Discuss with Mark Edward: What is mentalism, and how does it use our desire for the outlandish to be true against us? Why all so-called psychics are frauds, though a small percentage genuinely believes their own hype. Cold reading vs. hot reading, and how psychics use the results of these readings to convince you they're able to consult supernatural entities. What it was like to work for the Psychic Friends Network, and how Mark used his mentalist superpowers to mine information from people over the phone -- and keep them calling back. How big-name celebrity psychics ply their trade in front of large studio audiences while keeping the scam safely under control. And much more... Full show notes and resources can be found here: jordanharbinger.com/413 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Okt 20201h 19min

412: Breaking Up with My Narcissistic Grandma | Feedback Friday

412: Breaking Up with My Narcissistic Grandma | Feedback Friday

Your grandma is so self-centered and negative that your efforts to stay in touch with her are just making you miserable. How do you go about breaking up with your narcissistic grandma without feeling terrible? We'll tackle this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/412 On This Week's Feedback Friday, We Discuss: Your grandma is so self-centered and negative that your efforts to stay in touch with her are just making you miserable. How do you go about breaking up with your narcissistic grandma without feeling terrible? You grew up in a good-hearted, church-going family, but over time, you've come to the conclusion that you're an atheist. How do you break the news to them without losing their emotional -- and financial -- support? As two male nurses in a female-dominated field, you and your boss have noticed an extreme anti-male sentiment from at least three of your managers. Should you bring up your grievances to HR or just look for another job? We all cope with the pandemic in our own way, and some choose to drink more than they otherwise would. As your mother recently died from alcoholism, how can you interact with your booze-loving pals without being the killjoy in the Zoom room? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. And if you want to keep in touch with former co-host and JHS family Jason, find him on Twitter at @jpdef and Instagram at @JPD, and check out his other show: Grumpy Old Geeks. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Okt 202049min

411: Oliver Stone | Writing, Directing, and Surviving the Movie Game

411: Oliver Stone | Writing, Directing, and Surviving the Movie Game

Oliver Stone (@TheOliverStone) is a film director, producer, and writer known for tackling controversial political issues in films like JFK and Platoon. He is also the author of Chasing the Light: Writing, Directing, and Surviving Platoon, Midnight Express, Scarface, Salvador, and the Movie Game. What We Discuss with Oliver Stone: The lesson Oliver learned about humanity -- when he was a cab driver prior to becoming a world-famous director -- that still rings true for him today. Why Oliver chose to serve in the infantry during the Vietnam War when a lot of his contemporaries (including several presidents) did all they could do to avoid going. What happened when Oliver snuck an obscene amount of LSD into his uptight father's scotch one night. The projects Oliver has had to abandon in recent years, and why some of his earlier films would be impossible to make now. Oliver's candid thoughts on Vladimir Putin, the CIA, cyberwarfare, and the culpability of the American media in current affairs. And much more... Full show notes and resources can be found here: jordanharbinger.com/411 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Okt 20201h 3min

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