1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

Erik Weihenmayer (@ErikWeihenmayer) has kayaked the Grand Canyon and climbed Mount Everest -- blind. He is the author of Touch the Top of the World and co-author of No Barriers and The Adversity Advantage. What We Discuss with Erik Weihenmayer: How challenges unite us as human beings -- no matter our hardships or handicaps. Why losing his sight as a teenager didn't discourage Erik from excelling beyond the capacity of the world's most accomplished extreme athletes. How Erik embraces a "no barriers" philosophy to guide and lift others -- even when their own cultures seek to keep them down. Why Erik's not "the blind climber," but a climber who happens to be blind -- and why this makes all the difference. The instincts, senses, and technology that allow Erik to navigate around his dangerous terrains of choice without sight. And much more... Full show notes and resources can be found here: https://jordanharbinger.com/288 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Dec 20191h 5min

You find criticism somewhat punishing rather than productive -- especially when it's given by people you love. So how can you stop taking feedback so personally? We'll explore this and more on the latest Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Jason DeFillippo (@jpdef) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: https://jordanharbinger.com/287 On This Week's Feedback Friday, We Discuss: How should we refer to our listener base? Is there a reason to share your salary with anyone else? Is it your imagination that there's tension between you and the only other woman in the office? As a business owner, how should you respond to competition fishing for pricing? How do you find hangout buddies? What can you do to help your boss step up as the leader you need him or her to be? Are extremely confident people drawn to jobs like teaching? Or is it the job that brings out the best in people? How do you keep contacts in your network from going cold? How should you stop taking feedback so personally -- especially when it's given by the people you love? Life Pro Tip: Compliment people on what you want them to be, even if they may not live up to it yet. Because when people hear themselves referred to in a certain way, they'll be motivated to act more that way. Recommendation of the Week: Bikram: Yogi, Guru, Predator (And advice: Don't believe everything you see in any documentary. Always do some follow-up research before treating it as gospel!) Interested in doing some prison time with Jordan this February? It's filling up fast; reach out to prison@jordanharbinger.com for details! Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Jason on Twitter at @jpdef and Instagram at @JPD, join his podcasting club, and check out... See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Dec 201947min

Jack Barsky (@DeepCoverBarsky) joins us to discuss his book Deep Undercover: My Secret Life and Tangled Allegiances as a KGB Spy in America. This is part two of a two-part episode; part one can be found here! What We Discuss with Jack Barsky: We continue Jack Barsky's story that began in episode 285. Make sure you start there! How Jack handled a double life -- complete with two families. Why the once-powerful allure of Soviet-style communism began to wane over time for Jack. Why Jack decided to stay in the United States and become a "real" American. How Jack shook his KGB handlers. And so much more... And much more... Full show notes and resources can be found here: https://jordanharbinger.com/286 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Dec 201942min

Jack Barsky (@DeepCoverBarsky) joins us to discuss his book Deep Undercover: My Secret Life and Tangled Allegiances as a KGB Spy in America. This is part one of a two-part episode; part two airs later this week! What We Discuss with Jack Barsky: What Jack Barsky's childhood was like in postwar East Germany. The stickiness of Soviet-style communist ideology and how it appealed to young people on Jack's side of the Iron Curtain. How spies were recruited and trained during the Cold War. What skills Jack used to assimilate seamlessly into American culture. Why caution is a spy's best friend; paranoia is his enemy. And so much more... Full show notes and resources can be found here: https://jordanharbinger.com/285 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Dec 201945min

While doing a little Facebook stalking recently, you noticed that photos of your wife's ex-boyfriend's youngest look suspiciously like your own youngest. You're thinking about discreetly having your kid take a paternity test, but you're honestly not sure what you'd do if the results confirmed your suspicions. So what should you do? We'll try to help you with this and more on the latest Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Jason DeFillippo (@jpdef) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: https://jordanharbinger.com/284. On This Week's Feedback Friday, We Discuss: Should you secretly undertake a paternity test on your 11-year old? You're a cybersecurity student stuck in a career ditch. How do you dig yourself out? You struggle with stammering. What can you do to find your way through? How do you sell ideas without getting them stolen? What does "I'm here if you need anything" actually mean, and how far can you take it? Threatened by hackers, you wonder: where do old passwords go to die? Should you report your ex for a visa breach that could get them deported? How can you get out of spending Thanksgiving with your fiance's family for for much needed "me" time? Life Pro Tip: Next commute, take time to listen to your car without the radio on. Your ears may pick up on sounds you wouldn't otherwise notice that indicate it's time to take it to the shop. Recommendation of the Week: Hail Satan? A quick shout out to Kay for recommending Bikram: Yogi, Guru, Predator on Netflix! Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Jason on Twitter at @jpdef and Instagram at @JPD, join his podcasting club, and check out his other show: Grumpy Old Geeks. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! On...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Nov 201943min

Brian Koppelman (@BrianKoppelman) is a writer, filmmaker, producer, and director. He's currently the showrunner, co-creator, and executive producer of Billions on Showtime and the host of The Moment podcast. What We Discuss with Brian Koppelman: Law school is an expensive (but not completely useless) place to learn life lessons. How do you know when you've done work of "undeniable" quality -- in the absolute sense? The line between being an artist and being delusional is very thin. If you want to be a screenwriter, read a thousand screenplays. We focus so much on the hustle that sometimes we forget to focus on the work. And so much more… Full show notes and resources can be found here: https://jordanharbinger.com/283 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Nov 20191h 4min

Ken Perenyi is a former art forger who spent 34 years creating fake paintings that passed muster among the experts in the world's major auction houses and galleries. He comes clean to tell us how he got away with it in his book Caveat Emptor: The Secret Life of an American Art Forger. What We Discuss with Ken Perenyi: How Ken, as an academically disinclined New Jersey teenager with no artistic background and zero plans for the future, fell headfirst into the New York art scene of the '60s and '70s. What a fortuitous trip to The Metropolitan Museum of Art awakened in Ken and how it led from technical curiosity to natural talent to outright forgery. How Ken prematurely aged his work to appear hundreds of years old, the materials he used, and how long it took him to create forgeries that would fool even lifelong, devoted experts. The first nervous deal Ken ever made and how it fed an ambition to take his talents as far as they would go. How Ken survived scrutiny by the mafia and FBI, changed his ways, and now works on the level selling "high-class fakes" rather than "forgeries." And much more... Full show notes and resources can be found here: https://jordanharbinger.com/282 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Nov 20191h 35min

Your shopaholic wife spends like there's no tomorrow, and is irked that you won't add her to the account for the business you've been running since before you were married. In fact, she loves to gain sympathy from others by telling them you're hiding money away from her -- which irks you. But one practical question did recently come up: What happens to the money in that account if anything should ever happen to you and she doesn't have access to it? On this Feedback Friday, we delve into this and much more! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Jason DeFillippo (@jpdef) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: https://jordanharbinger.com/281. On This Week's Feedback Friday, We Discuss: Interested in doing some prison time with Jordan next February? It's filling up fast; reach out to prison@jordanharbinger.com for details! It's been a long day. Are you a jerk for not letting someone cut in front of you in the grocery store checkout line just because they say their child is waiting for them in their car and everyone behind you already let them through? You were able to use the tips you learned about negotiation in our episodes with Alex Kouts and Ramit Sethi to get a raise from your old boss. But now that it's time to ask for an increase, you've got a new boss with whom you haven't yet established rapport. Should you wait? In another nod to the Alex Kouts episodes, you've negotiated the raises to elevate you into a higher tax bracket -- but you're clueless about how to behave in the associated culture. How do you fit in with your new peers without feeling like you just landed on another planet? Even though your parents don't let your 10-year-old sister use Instagram because they don't want her interacting with creepy DMs from predators, she's allowed to use TikTok because of the "funny videos" even though you know the creeps are there, too. How can you keep her safe? Three years ago, you married a widow whose husband died three years before that. You don't really have a problem talking about him with her, but you no longer want to visit his grave with her where she breaks down and makes you feel like a consolation prize. Is this wrong of you? Your shop-happy wife is irked that she doesn't have access to the business account you've had since before you got married, and... See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Nov 201942min